The Effects of Exercise Intensity and Initial Timing on Functional Recovery after Sciatic Nerve Crush Injury in Rats

Junyan Cai; 나상수; KAK HWANGBO (황보각)

The Effects of Exercise Intensity and Initial Timing on Functional Recovery after Sciatic Nerve Crush Injury in Rats

Journal of the Korean Society of Physical Medicine
Abbr : J Korean Soc Phys Med
2015, 10(3), pp.219-225
Publisher : The Korean Society of Physical Medicine
Research Area : Medicine and Pharmacy > Physical Therapy > Other physical therapy

Junyan Cai ¹, 나상수 ², KAK HWANGBO ²

¹Affiliated Hospital of Nantong University
²대구대학교

Accredited

ABSTRACT

PURPOSE: The aim of this study was to investigate the effects of exercise intensity and initial timing on functional recovery following sciatic nerve injury in rats. METHODS: Total of 80 Sprague-Dawley rats was used and randomly divided 6 groups. Under deep anesthesia, the sciatic nerve was nipped by adapted hemostatic tweezers for 30 seconds and the injured nerve was transparent under naked eyes. Acute exercise groups was applied treadmill after sciatic nerve crush injury during 5days with three type intensity. Late exercise groups was also applied treadmill during 5 days with three type intensity after 5 days break. Values of sciatic functional index were measured and analyzed in each group after exercise period. RESULTS: The sciatic functional index values between control groups 1, acute low-intensity group, acute middleintensity group in acute phase showed statistical significant (p<.05). The sciatic functional index values between control groups 2, late low-intensity group, late middle-intensity group and late high-intensity in late phase showed statistical significant (p<.05). The comparison in acute and late phase, sciatic functional index values of each low-intensity group and each high-intensity group showed statistical significant (p<.05). CONCLUSION: Whether at acute or late phase, treadmill exercise as a therapy obtained beneficial effects of functional recovery and exercise training at low speed is more beneficial effects on the recovery of motor function in acute phase.

KEYWORDS

Sciatic nerve injury, Treadmill exercise, Intensity and initial timing

Citation status

* References for papers published after 2023 are currently being built.

[journal] Bain J / 1989 / Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat / Plastic and reconstructive surgery 83(1) : 129~136

[journal] Bobinski F / 2011 / Neuroprotective and neuroregenerative effects of low-intensity aerobic exercise on sciatic nerve crush injury in mice / Neuroscience 194 : 337~348

[journal] Byun Y / 2005 / Treadmill running promotes functional recovery and decreases brain-derived neurotrophic factor mRNA expression following sciatic crushed nerve injury in rats / Journal of sports medicine and physical fitness 45(2) : 222~

[journal] de Medinaceli L / 1982 / An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks / Experimental neurology 77(3) : 634~643

[journal] Ilha J / 2008 / Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats / Neurorehabilitation and neural repair 22(4) : 355~366

[journal] Intiso D / 2010 / Functional outcome and health status of injured patients with peripheral nerve lesions / Injury 41(5) : 540~543

[journal] Kuphal KE / 2007 / Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents / The Journal of Pain 8(12) : 989~997

[journal] Marqueste T / 2006 / Chronic electrostimulation after nerve repair by self-anastomosis: effects on the size, the mechanical, histochemical and biochemical muscle properties / Acta neuropathologica 111(6) : 589~600

[journal] Monte-Raso VV / 2010 / A new treadmilltype motorized walking belt machine for video recording of the rat's gait and sciatic functional index measurement. A comparative study with other methods / Journal of neuroscience methods 189(1) : 23~29

[journal] Penna V / 2012 / The long‐term functional recovery of repair of sciatic nerve transection with biogenic conduits / Microsurgery 32(5) : 377~382

[journal] Rochkind S / 2007 / Laser phototherapy (780 nm), a new modality in treatment of long-term incomplete peripheral nerve injury: a randomized double-blind placebo-controlled study / Photomedicine and laser surgery 25(5) : 436~442

[journal] Sabatier MJ / 2008 / Treadmill training promotes axon regeneration in injured peripheral nerves / Experimental neurology 211(2) : 489~493

[journal] Seo TB / 2006 / Involvement of Cdc2 in axonal regeneration enhanced by exercise training in rats / Medicine and science in sports and exercise 38(7) : 1267~1276

[journal] Small SP. / 2004 / Preventing sciatic nerve injury from intramuscular injections: literature review / Journal of advanced nursing 47(3) : 287~296

[journal] Sobral L / 2008 / Immediate versus later exercises for rat sciatic nerve regeneration after axonotmesis: histomorphometric and functional analyses / Brazilian Journal of Physical Therapy 12(4) : 311~316

[journal] Tam SL / 2001 / Increased neuromuscular activity reduces sprouting in partially denervated muscles / The Journal of Neuroscience 21(2) : 654~667

[journal] Udina E / 2011 / Effects of activity-dependen t strategies on regeneration and plasticity after periphera l nerve injuries / Annals of Anatomy- Anatomischer Anzeiger 193(4) : 347~353

[journal] Weber RA / 1993 / Autotomy and the sciatic functional index / Microsurgery 14(5) : 323~327

[journal] Winter B / 2007 / High impact running improves learning / Neurobiology of learning and memory 87(4) : 597~609

[journal] Zhang P / 2012 / Very early-initiated physical rehabilitation protects against ischemic brain injury / Front. Biosci 4 : 2476~2489

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