Journal of the Korean Society of Physical Medicine 2023 KCI Impact Factor : 0.45
-
pISSN : 1975-311X / eISSN : 2287-7215
- https://journal.kci.go.kr/kspm
KJCKorea
Journal Central
Exercise Intervention on Blood Glucose Control of Type 2 Diabetes with Obesity: A Systematic Review
- Journal of the Korean Society of Physical Medicine
- Abbr : J Korean Soc Phys Med
- 2018, 13(1), pp.11-26
- DOI : 10.13066/kspm.2018.13.1.11
- Publisher : The Korean Society of Physical Medicine
- Research Area : Medicine and Pharmacy > Physical Therapy > Other physical therapy
- Received : September 15, 2017
- Accepted : November 13, 2017
- Published : February 28, 2018
Jung Su Ryun 1, 김완수 2
1경남대학교
2대구대학교 건강증진학과
Accredited
ABSTRACT
PURPOSE: The aim of this study was to review the effects of exercise intervention on blood glucose control in obese type 2 diabetic patients. METHODS: The PubMed and KERISS search engines were used and 61 papers that met the key questions were selected. RESULTS: Exercise is an effective intervention for the control of blood glucose in type 2 diabetic patients because it does not impair glucose transport in the skeletal muscle induced by muscle contractions. Insulin resistance, which is characteristic of type 2 diabetes, is caused by decreased insulin sensitivity or insulin responsiveness. Acute exercise improves the glucose metabolism by increasing the insulin-independent signaling pathways and insulin sensitivity in the skeletal muscle, and regular long-term exercise improves the skeletal muscle insulin responsiveness and systemic glucose metabolism by increasing the mitochondrial and GLUT4 protein expression in the skeletal muscle. CONCLUSION: The improvement of the glucose metabolism through exercise shows a dose-response pattern, and if exercise consumes the same number of calories, high intensity exercise will be more effective for the glucose metabolism. On the other hand, it is practically difficult for a patient with obese type 2 diabetes to control their blood glucose with high intensity or long-term exercise. Therefore, it will be necessary to study safe adjuvants (cinnamic acid, lithium) that can produce similar effects to high-intensity and high-volume exercises in low-intensity and low-volume exercises.
Statistics
-
296 Viewed
-
1 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
Alam MA
/ 2016
/ Hydroxycinnamic acid derivatives: A potential class of natural compounds for the management of lipidmetabolism and obesity
/ NutrMetab
13
: 27~
[journal]
Arias EB
/ 2007
/ Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle
/ Am J Physiol Endocrinol Metab
292
: E1191~E200
[journal]
Becker-Zimmermann K
/ 1982
/ Treadmill training improves intravenous glucose tolerance and insulin sensitivity in fatty Zucker rats
/ Diabetologia
22(6)
: 468~474
[journal]
Bergstrom J
/ 1966
/ Muscle glycogen synthesis after exercise: an enhancing factor localized to the muscle cellsin man
/ Nature
10
: 309~310
[journal]
Brozinick JT Jr
/ 1994
/ The effects of muscle contraction and insulin on glucosetransporter translocation in rat skeletal muscle
/ Biochem J
297
: 539~545
[journal]
Calegari VC
/ 2011
/ Endurance training activates AMP-activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets
/ J Endocrinol
208(3)
: 257~264
[journal]
Camera DM
/ 2010
/ Early time course of Akt phosphorylation after endurance and resistance exercise
/ Med Sci Sports Exerc
42(10)
: 1843~1852
[journal]
Cartee GD
/ 1993
/ Persistent effects of exercise on skeletal muscle glucose transport across the life-span of rats
/ J Appl Physiol
75
: 972~978
[journal]
주민
/ 2013
/
Comparison of Body Composition of College Students after 4week Jump-roping Exercise
/ 대한물리의학회지
/ 대한물리의학회
8(4)
: 627~635
[journal]
Colberg SR
/ 2010
/ Exercise and type 2 diabetes: american college of sports medicine and the american diabetes association: joint position statement. Exercise and type 2 diabetes
/ Med Sci Sports Exerc
42(12)
: 2282~2303
[journal]
Combes A
/ 2015
/ Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle
/ Physiol Rep
3(9)
: e12462~
[journal]
Consitt LA
/ 2013
/ Impairments in site-specific AS160 phosphorylation and effects of exercise training
/ Diabetes
62(10)
: 3437~3447
[journal]
Cortez MY
/ 1991
/ Insulin resistance of obese Zucker rats exercise trained at two different intensities
/ Am J Physiol
261(5)
: E613~E619
[journal]
Douen AG
/ 1990
/ Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin-and exercise-recruitabletransporter pools in skeletal muscle
/ J Biol Chem
265(23)
: 13427~13430
[journal]
Edgett BA
/ 2013
/ Mammalian target of rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle
/ Appl Physio lNutr Metab
38(8)
: 862~869
[journal]
Etgen GJ Jr
/ 1996
/ Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat
/ Am J Physiol
271(2)
: E294~E301
[journal]
Furnsinn C
/ 1997
/ More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle
/ Am J Physiol
273(3)
: E514~E520
[journal]
Goodyear LJ
/ 1995
/ Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
/ J Clin Invest
95(5)
: 2195~2204
[journal]
Goodyear LJ
/ 1991
/ Exercise-induced translocation of skeletal muscle glucose transporters
/ Am J Physiol
261(6)
: E795~E799
[journal]
Goodyear LJ
/ 1998
/ Exercise, glucose transport, and insulin sensitivity
/ Annu Rev Med
49
: 235~261
[journal]
Harrell NB
/ 2007
/ Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium
/ Arch PhysiolBiochem
113(4-5)
: 221~227
[journal]
Haugaard ES
/ 1974
/ Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm
/ Biochem Pharmacol
23(12)
: 1675~1685
[journal]
Hayashi T
/ 1997
/ Exercise regulation of glucose transport in skeletal muscle
/ Am J Physiol
273(6)
: E1039~E1051
[journal]
Ivy JL
/ 2004
/ Muscle insulin resistance amended with exercise training: role of GLUT4 expression
/ Med Sci Sports Exerc
36(7)
: 1207~1211
[journal]
Jung SR
/ 2017
/ Effect of Lithium on Mechanism of Glucose Transport in Skeletal Muscles
/ J NutrSciVitaminol
63
: 365~371
[journal]
Katta A
/ 2009
/ Altered regulation of contraction-induced Akt/mTOR/p70S6k pathway signaling in skeletal muscle of the obese Zucker rat
/ Exp Diabetes Res
: 384683~
[journal]
Kemp BE
/ 1999
/ Dealing with energy demand: the AMP-activated protein kinase
/ Trends BiochemSci
24(1)
: 22~25
[journal]
Kennedy JW
/ 1999
/ Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
/ Diabetes
48(5)
: 1192~1197
[journal]
김현애
/ 2011
/
Analysis of the Chest Expansion and Pulmonary Function in the 20s men Obesity according to Position Change
/ 대한물리의학회지
/ 대한물리의학회
6(3)
: 247~256
[journal]
김완수
/ 2017
/
The Characteristics of Risk Factors in Korean CAD Patients Comparing to American Counterpart and Its Implications to Prevention of CAD
/ 대한물리의학회지
/ 대한물리의학회
12(2)
: 9~20
[journal]
김완수
/ 2013
/
The Effect of Obesity, Blood Pressure and Lifestyle on Lipid indices and Blood pressure in Men of Age 40s
/ 대한물리의학회지
/ 대한물리의학회
8(2)
: 239~243
[journal]
King PA
/ 1993
/ Exercise, unlike insulin, promotes glucose transporter translocation in obese Zucker rat muscle
/ Am J Physiol
265(2)
: R447~R452
[journal]
Kleinert M
/ 2014
/ Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
/ Mol Metab
3(6)
: 630~641
[journal]
Klip A
/ 1990
/ Recruitment of GLUT-4 glucose transporters by insulin in diabetic rat skeletal muscle
/ Biochem Biophys Res Commun
172(2)
: 728~736
[journal]
임창훈
/ 2015
/
The Effects of the Combined Exercise Program on PhysicalFitness and Related Hormone in Elderly Women
/ 대한물리의학회지
/ 대한물리의학회
10(1)
: 53~61
[journal]
Luo L
/ 2013
/ Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats
/ Exp Gerontol
48(4)
: 427~436
[journal]
Maarbjerg SJ
/ 2011
/ Current understanding of increased insulin sensitivity after exerciseemerging candidates
/ Acta Physiol (Oxf)
202(3)
: 323~335
[journal]
Mascher H
/ 2011
/ Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects
/ Acta Physiol (Oxf)
202(2)
: 175~184
[journal]
McGarry JD
/ 1998
/ Glucose-fatty acid interactions in health and disease
/ Am J Clin Nutr
67(3 Suppl)
: 500S~504S
[journal]
Merrill GF
/ 1997
/ AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
/ Am J Physiol
273(6)
: E1107~E1112
[journal]
Michelle Furtado L
/ 2003
/ GLUT4 activation: thoughts on possible mechanisms
/ Acta Physiol. Scand
178
: 287~296
[journal]
Nitert MD
/ 2012
/ Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
/ Diabetes
61(12)
: 3322~3332
[journal]
옥해안
/ 2017
/
The Effects of Aquatic Group Exercise on Body Composition and Mental Health of Elderly Women
/ 대한물리의학회지
/ 대한물리의학회
12(1)
: 103~112
[journal]
Prabhakar PK
/ 2011
/ Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on2-deoxyglucose uptake in 3T3-L1 adipocytes
/ J Agric Food Chem
59
: 9835~9844
[journal]
Pugh JK
/ 2015
/ Acute molecular responses to concurrent resistance and high-intensity interval exercise in untrained skeletal muscle
/ Physiol Rep
3(4)
: e12364~
[journal]
Rohling M
/ 2016
/ Effects of long-term exercise interventions on glycaemic control in type 1 and type 2 diabetes: a systematic review
/ Exp Clin Endocrinol Diabetes
124(8)
: 487~494
[journal]
Roden M
/ 2012
/ Exercise in type 2 diabetes: to resist or to endure
/ Diabetologia
55(5)
: 1235~1239
[journal]
Ryder JW
/ 2000
/ Use of a novel impermeable biotinylatedphotolabeling reagent to assess insulinand hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
/ Diabetes
49(4)
: 647~654
[journal]
Sharoff CG
/ 2010
/ Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulinresistant individuals
/ Am J Physiol Endocrinol Metab
298
: E815~E823
[journal]
Sriwijitkamol A
/ 2007
/ Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study
/ Diabetes
56(3)
: 836~848
[journal]
Stanford KI
/ 2014
/ Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle
/ Adv Physiol Educ
38(4)
: 308~314
[journal]
Stein SA
/ 2013
/ A review of the efficacy and safety of oral antidiabetic drugs
/ Expert Opin Drug Saf
12
: 153~175
[journal]
Stuart CA
/ 2010
/ Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers
/ Med Sci Sports Exerc
42(1)
: 96~106
[journal]
Sylow L
/ 2014
/ Rac1-a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
/ Exp Physiol
99(12)
: 1574~1580
[journal]
Tabata I
/ 1994
/ Lithium increases susceptibility of muscle glucose transport to stimulation by various agents
/ Diabetes
43(7)
: 903~907
[journal]
Thomson DM
/ 2008
/ AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
/ J Appl Physiol
104(3)
: 625~632
[journal]
Vendelbo MH
/ 2014
/ Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise
/ J Appl Physiol
117(3)
: 289~296
[journal]
Vissing K
/ 2013
/ Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals
/ Scand J Med Sci Sports
23(3)
: 355~366
[journal]
Wallberg-Henriksson H
/ 1988
/ Glucose transport into rat skeletal muscle: interaction between exercise and insulin
/ J Appl Physiol
65(2)
: 909~913
[journal]
Witczak CA
/ 2008
/ AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism
/ Cell Mol Life Sci
65(23)
: 3737~3755
[journal]
Wojtaszewski JF
/ 2000
/ Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
/ Diabetes
49(3)
: 325~331
[journal]
Zhao R
/ 2014
/ LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats
/ Food Funct
5(4)
: 811~820