Korean Journal of Medical Ethics 2023 KCI Impact Factor : 1.21
-
pISSN : 2005-8284 / eISSN : 2234-3598
- https://journal.kci.go.kr/medethics
KJCKorea
Journal Central
The Definition and Ethical Issues of Part-Human Animals
- Korean Journal of Medical Ethics
- Abbr : 의료윤리
- 2013, 16(1), pp.27-40
- DOI : 10.35301/ksme.2013.16.1.27
- Publisher : The Korean Society For Medical Ethics
- Research Area : Medicine and Pharmacy > General Medicine
- Published : April 30, 2013
모효정 1
1이화여자대학교
Accredited
ABSTRACT
Recent advances in the development of biotechnology have led to the creation of a variety of organisms, named part-human animals, with both human and animal components. Scientists have created part-human animals that have both human cells and animal cells in their body. I want to avoid the term 'chimera' and 'hybrid' because of using both creation methods of chimeras and hybrids in making part-human animals. The part-human animals might hold enormous potential for clinical application as well as basic research into human physiology. Despite its potential, however, the progression of part-human animal research has given rise to many ethical concerns. The arguments against the creation of part-human animals are related to the concerns about human dignity and moral confusion and also the crossing and violating of the “species boundary” are morally repugnant and wrong. For these reason, we found that the public's negative attitudes toward making part-human animals, We should know that part-human animals research is required the deeply consideration.
Statistics
-
872 Viewed
-
170 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[web]
/ 2012
/ 부모가 여섯 키메라 원숭이 태어났다
/ 경향신문
/ http://news.khan.co.kr/kh_news/khan_art_view.html?artid=201201062126175&code=930401
[journal]
Fehilly CB
/ 1984
/ Interspecific chimaerism between sheep and goat
/ Nature
307(5952)
: 634~636
[journal]
McCune JM
/ 1988
/ The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function
/ Science
241(4873)
: 1632~1639
[journal]
Uchida N
/ 2000
/ Direct isolation of human central nervous system stem cells
/ Proc Natl Acad Sci USA
97(26)
: 14720~14725
[journal]
Almeida-Porada G
/ 2004
/ Formation of human hepatocytes by human hematopoietic stem cells in sheep
/ Blood
104(8)
: 2582~2590
[book]
Institute of Medicine
/ 1996
/ Xenotransplantation: Science, Ethics, and Public Policy
/ National Academy Press
[web]
/ 2011
/ Daily Mail article
/ http://www.dailymail.co.uk/sciencetech/article-2017818/Embryos-involving-genes-animals-mixed-humans-produced-secretively-past-years.html
[web]
Knowles LP
/ 2009
/ Ethics of Research Using Hybrids, Chimeras and Cytoplasmic Hybrids
/ Stem Cell Network
/ http://www.stemcellnetwork.ca/uploads/File/whitepapers/Ethics-of%20Research-Using-Hybrids.pdf
[report]
Bioethics Advisory Committee
/ 2010
/ Singapore: Human-Animal Combinations in Stem Cell Research
: E1~E3
[journal]
Namikawa R
/ 1988
/ Infection of the SCID-human mouse by HIV-1
/ Science
242(4886)
: 1684~1686
[journal]
Robert JS
/ 2006
/ The science and ethics of making part-human animals in stem cell biology
/ FASEB J
20(7)
: 838~845
[journal]
Muotri AR
/ 2005
/ Development of functional human embryonic stem cell-derived neurons in mouse brain
/ Proc Natl Acad Sci USA
102(51)
: 18644~18648
[journal]
Cascalho M
/ 2005
/ New technologies for organ replacement and augmentation
/ Mayo Clin Proc
80(3)
: 370~378
[journal]
Guenechea G
/ 20
/ Distinct classes of human stem cells that differ in proliferative and selfrenewal potential
/ Nat Immunol
2(1)
: 75~82
[journal]
Raychaudhuri SP
/ 2001
/ Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation
/ Br J Dermatol
144(5)
: 931~939
[journal]
Yokoo T
/ 2005
/ Ex vivo regeneration of the murine kidney from human mesenchymal stem cells
/ Kidney Int
68(5)
: 1967~
[journal]
Goldstein RS
/ 2002
/ Integration and differentiation of human embryonic stem cells transplanted to the chick embryo
/ Developmental Dynamics
225(1)
: 80~86
[journal]
Kroon E
/ 2008
/ Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
/ Nature Biotechnology
26(4)
: 443~452
[book]
Streiffer R. Human
/ 2010
/ The Stanford Encyclopedia of Philosophy (Spring 2011 edition)
/ First published
[journal]
Baylis F
/ 2007
/ Chimera research and stem cell therapies for human neurodegenerative disorders
/ Camb Q Healthc Ethics
16(2)
: 195~208
[journal]
Ravelingien A
/ 2006
/ On the moral status of humanized chimeras and the concept of human dignity
/ Between The Species
6
: 22~31
[book]
Comstock G
/ 2000
/ Vexing Nature? On the Ethical Case against Agricultural Biotechnology
/ Kluwer Academic Publishers
: 185~
[book]
Paul J II
/ 1979
/ Theology of the Body: Human Love in the Divine Plan
/ Pauline Books and Media
[journal]
Leon K
/ 1997
/ The wisdom of repugnance
/ New Republic
216(22)
: 17~26
[other]
/ 2007
/ Danish Council of Ethics and the Danish Ethical Council for Animals: Man or Mouse?
/ Ethical aspects of chimera research. 2007 : Chapter 4
[journal]
Robert JS
/ 2003
/ Crossing species boundaries
/ Am J Bioeth
3(3)
: 1~13
[journal]
Streiffer R
/ 2003
/ In defense of the moral relevance of species boundaries
/ Am J Bioeth
3(3)
: 37~38
[journal]
Cohen CB
/ 2003
/ Creating human-nonhuman chimeras: of mice and men
/ Am J Bioeth
3(3)
: W3~
[web]
Human Fertilisation Embryonic Authority
/ 2007
/ UK: Hybrids and Chimeras: A consultation on the ethical and social implications of creating human/animal embryos in research
/ http://www.hfea.gov.uk/docs/Hybrids_Report.pdf
[journal]
DeGrazia D
/ 2007
/ Human-animal chimeras: human dignity, moral status, and species prejudice
/ Metaphilos
38(2-3)
: 309~329
[journal]
Johnston J
/ 2003
/ Chimeras and human dignity
/ Am J Bioeth
3(3)
: W6~W8
[journal]
Karpowicz P
/ 2005
/ Developing human-nonhuman chimeras in human stem cell research: Ethical issues and boundaries
/ Kennedy Inst Ethics J
15(2)
: 170~134
[journal]
Ravelingien A
/ 2006
/ On the moral status of humanized chimeras and the concept of human dignity
/ Between the Species
[book]
Gewirth A
/ 1992
/ Human Dignity as the Basis of Rights, In The Constitution of Rights: Human Dignity and American Values
/ Cornell University Press
: 10~28
[journal]
Baylis F
/ 2007
/ Part-human chimeras: worrying the facts, probing the ethics
/ Am J Bioeth
7(5)
: 41~58
[confproc]
Weschka M
/ 2006
/ Protocol of the CHIMBRIDS Opening Conference on 11/12 March 2006
: 7~
[book]
Taupitz J
/ 2009
/ Chimbrids-Chimeras and Hybrids in Comparative European and International Research: Scientific, Ethical, Philosophical and Legal Aspects
/ Springer
[journal]
Greely HT
/ 2007
/ Thinking about the human neuron mouse
/ Am J Bioeth
7(5)
: 27~40
This paper was written with support from the National Research Foundation of Korea.