Stimulation of the Immune Response by Herbal Formulas for Taeeumin (대표적인 태음인 처방의 면역 활성화 비교 연구)

정다영; 하혜경; 이호영; 이진아; Nam-Hun Lee (이남헌); 이준경; 황대선; 신현규

Stimulation of the Immune Response by Herbal Formulas for Taeeumin

Journal of Sasang Constitution and Immune Medicine
Abbr : JSCIM
2010, 22(3), pp.141~151
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

정다영 ¹, 하혜경 ², 이호영 ¹, 이진아 ¹, Nam-Hun Lee ¹, 이준경 ¹, 황대선 ¹, 신현규 ¹

¹한국한의학연구원 표준화연구본부 한약EBM연구센터
²한국한의학연구원 한약EBM연구센터

Accredited

ABSTRACT

1. Objectives Three herbal formulas (Yuldahanso-tang, Chungsimyonja-tang, and Taeeumjowi-tang) for Taeeumin were applied to investigate the immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in murine macrophage cell line (RAW 264.7) and ovalbumin (OVA)-immunized mice. 2. Methods This study was carried out in nitric oxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes according to three herbal formulas. C57BL/6 mice were immunized intraperitonially with OVA/ aluminium (100 ㎍/200 ㎍/mouse) on day 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. 3. Results Yuldahanso-tang and Chungsimyonja-tang increased NO synthesis in RAW 264.7 cells. Three herbal formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<.001). Three herbal formulas for Taeeumin also significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. 4. Conclusion These results suggested that three herbal formulas for Taeeumin could be used as stimulator of immune response.

KEYWORDS

Yuldahanso-tang (Reduohanshao-tang), Chungsimyonja-tang (Qingxinlianzi-tang), Taeeumjowi-tang (Taiyintiaowei- tang), Immune response

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