@article{ART002709459},
author={Lee Ji-young and Park Seong-sik},
title={Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2000},
volume={12},
number={2},
pages={171-183}
TY - JOUR
AU - Lee Ji-young
AU - Park Seong-sik
TI - Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2000
VL - 12
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 171
EP - 183
SN - 1226-4075
AB - 1. Back ground and purpose An experimental study has done to examine the effect of defense and cure gastric mucasal damage of Mokdan-pijihwang-tang.
2. Methods Mice had intragastric injected with MJ extract before indomethacin treatment which induces homorrhage infarct and erosion artificially. Degree of lipid peroxidation, general morphology, change of mucous cell, the distribution of PNA, ICAM and distribution of apoptotic cell were objected.
(Abbreviation) MJ : Mokdanpijihwang-tang, PNA : Peanut Agglutinin, ICAM : Intercellular Adhesion Molecule 3 Results 1) The degree of lipid peroxidation in INDO-group had increased conspicuously than control group. But the degree of lipid peroxidation in MJ-group had decreased than INDO-group and these decline had probability.
2) After indomethacin treatment, hemorrhage infarct and erosion had increased in stomach body. But in MJ-group, the configuration is normal, except the group intragastric injected with MJ extract at hour 24 before indomethacin treatment.
3) Surface mucous cell and neck mucous had disappeared in INDO-group. But in MJ-group tormal distribution had shown like control group except the group intragastric injected with MJ extract at hour 24 before indomethacin treatment.
4) PNA positive reaction had not shown in INDO-group. But medium PNA positive reaction had shown In Mj-group.
5) ICAM positive reacted cell had shown in INDO-group. The decrease of ICAM positive cell were shown than INDO-group.
6) A number of apoptotic cell was distributed in hemorrhagic erosion. A few number of apoptotic cell was distributed in MJ-group except some surface mucous.
4. Conclusion These results suggest that MJ has an effect on cure of gastric mucosal damage.
KW - Mokdanpijihwang-tang;Gastric mucosal damage;Lipid peroxidation;Mucos cell;PNA;ICAM
DO -
UR -
ER -
Lee Ji-young and Park Seong-sik. (2000). Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice. Journal of Sasang Constitution and Immune Medicine, 12(2), 171-183.
Lee Ji-young and Park Seong-sik. 2000, "Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice", Journal of Sasang Constitution and Immune Medicine, vol.12, no.2 pp.171-183.
Lee Ji-young, Park Seong-sik "Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice" Journal of Sasang Constitution and Immune Medicine 12.2 pp.171-183 (2000) : 171.
Lee Ji-young, Park Seong-sik. Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice. 2000; 12(2), 171-183.
Lee Ji-young and Park Seong-sik. "Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice" Journal of Sasang Constitution and Immune Medicine 12, no.2 (2000) : 171-183.
Lee Ji-young; Park Seong-sik. Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice. Journal of Sasang Constitution and Immune Medicine, 12(2), 171-183.
Lee Ji-young; Park Seong-sik. Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice. Journal of Sasang Constitution and Immune Medicine. 2000; 12(2) 171-183.
Lee Ji-young, Park Seong-sik. Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice. 2000; 12(2), 171-183.
Lee Ji-young and Park Seong-sik. "Effects of Mokdanpijihwang-tang on gastric mucosal damage in mice" Journal of Sasang Constitution and Immune Medicine 12, no.2 (2000) : 171-183.
