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Acute Toxicity Study on Taeeumjowi-tang in Mice

  • Journal of Sasang Constitution and Immune Medicine
  • Abbr : J Sasang Constitut Med
  • 2010, 22(2), pp.101-107
  • Publisher : The Society of Sasang Constitution and Immune Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

마진열 1 황대선 2 서창섭 2 이시우 3 김종열 2 신현규 2

1한의융합연구본부
2한국한의학연구원
3한국한의학연구원 의료연구부

Accredited

ABSTRACT

1. Objectives The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 ㎎/㎏. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 ㎎/㎏). In conclusion, LD50 of Taeeumjowi-tang was over 5000 ㎎/㎏ and it is very safe to mice.

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