Stimulation of the Immune Response by Herbal Formulas for Taeeumin (대표적인 태음인 처방의 면역 활성화 비교 연구)

정다영; 하혜경; 이호영; 이진아; Nam-hun Lee (이남헌); 이준경; 황대선; 신현규

Stimulation of the Immune Response by Herbal Formulas for Taeeumin

Journal of Sasang Constitution and Immune Medicine
Abbr : J Sasang Constitut Med
2010, 22(3), pp.141-151
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine

정다영 ¹, 하혜경 ², 이호영 ¹, 이진아 ¹, Nam-hun Lee ¹, 이준경 ¹, 황대선 ¹, 신현규 ¹

¹한국한의학연구원 표준화연구본부 한약EBM연구센터
²한국한의학연구원 한약EBM연구센터

Accredited

ABSTRACT

1. Objectives Three herbal formulas (Yuldahanso-tang, Chungsimyonja-tang, and Taeeumjowi-tang) for Taeeumin were applied to investigate the immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in murine macrophage cell line (RAW 264.7) and ovalbumin (OVA)-immunized mice. 2. Methods This study was carried out in nitric oxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes according to three herbal formulas. C57BL/6 mice were immunized intraperitonially with OVA/ aluminium (100 ㎍/200 ㎍/mouse) on day 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. 3. Results Yuldahanso-tang and Chungsimyonja-tang increased NO synthesis in RAW 264.7 cells. Three herbal formulas significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<.001). Three herbal formulas for Taeeumin also significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. 4. Conclusion These results suggested that three herbal formulas for Taeeumin could be used as stimulator of immune response.

KEYWORDS

Yuldahanso-tang (Reduohanshao-tang), Chungsimyonja-tang (Qingxinlianzi-tang), Taeeumjowi-tang (Taiyintiaowei- tang), Immune response

Citation status

* References for papers published after 2023 are currently being built.

[journal] Kim KY / 1994 / Consideration about medicine historical view of Je-Ma Lee / J Sasang Constitut Med 6(1) : 11~19

[journal] Cho DW / 1996 / Genetic analysis study of sasang constitution classification by DNA-fingerprinting methods / J Sasang Constitut Med 8(2) : 151~163

[journal] Hur SM / 2005 / Alteration of molecules and cytokines related to the activation of T lymphocyte / J Korean Surg Soc 19(2) : 119~123

[journal] 서영배 / 2003 / Experimental Studies on Thymus Cells Differentiation by the Extracts of Stigma Croci / 대한본초학회지 / 대한본초학회 18(3) : 13~111

[journal] 장수정 / 2006 / Effects of Deer Antler Extract on Serum IGF-Ⅰ, Bone Growth and Splenocyte Proliferation in Growing Rats / 한국영양학회지 / 한국영양학회 39(3) : 225~235

[journal] Friedl R / 2001 / Stimulation of nitric oxide synthesis by the aqueous extract of Panax ginsena root in Raw 264.7 cells / Br J pharmacol 134 : 1663~1670

[journal] Farrell AJ / 1996 / Nitric oxide / nnals of the Rheumatic Dieases 55 : 7~20

[journal] 류혜숙 / 2004 / Enhancing Effect of Zingiber Officinale Roscoe Extracts on Mouse Spleen and Macrophage Cells Activation / 한국영양학회지 / 한국영양학회 37(9) : 780~785

[journal] Sun J / 2007 / Adjuvant effects protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune reponses to ovalbumin in mice / Vaccine 25 : 1114~1120

[journal] Choi YJ / 1998 / Effects of Yuldahansotang water extract on blood pressure, regional cerebral blood flow and pial arterial diamter / J Sasang Constitut Med 10(1) : 285~293

[journal] Choi JS / 2001 / Studies on the cytokine production regulation in human astrocytes by Yuldahansotang / J Sasang Constitut Med 13(1) : 61~69

[journal] Lee JH / 2002 / Effects of Yuldahansotang water ectract on cultured primary hippocampal cell culture damaged by hydrogen peroxide / J Sasang Constitut Med 14(1) : 79~89

[journal] Hong JH / 2001 / Effects of Yuldahansotang water extract on cultured spinal sensory neurons damaged by xanthine oxidase/hypoxanthine / J Sasang Constitut Med 13(1) : 88~96

[journal] 주입산 / 2005 / Studies of Cheongsimyeonja-tang and Taeeumjowi-tang that Get Change by Wistar Rat's Aging / 사상체질의학회지 / 사상체질의학회 17(2) : 74~84

[journal] 김길수 / 2007 / Anti-obesity and Anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription / 동의신경정신과학회지 / 대한한방신경정신과학회 18(2) : 57~74

[journal] Kim MW / 2001 / Effects of Taeeumjowetang on lipid peroxidation by free radicals and oxidative damage of hepatocytes by tert-butyl hybroperoxide / J Sasang Constitut Med 13(1) : 51~60

[journal] 임종필 / 2007 / The Anti-oxidative and Immune-regulatory Effectof Chungsimyeonja-tang in Aged Rat / 사상체질의학회지 / 사상체질의학회 19(3) : 227~241

[journal] Park SC / 2003 / Effects CheongSimYeonJaTang(CSYJT) on control of immune-function in highly purified mouse B cells and Mast cell / J Sasang Constitut Med 15(2) : 166~179

[journal] Hong SC / 1995 / An experimental study on the anti-stress effects by taeeumin Chongsimyonjat `ang / J Sasang Constitut Med 7(2) : 227~240

[journal] Liew FY / 1990 / Tumor necrosis factor synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide / J Immunol 145 : 4306~4310

[journal] Higuchi M / 1990 / Cytolytic mechanism of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanism of activated macrophages / J Immunol 144(4) : 1425~1431

[journal] Kawamata H / 2000 / Enhanced expreesion of inducible nitric oxide synthase by Juzen-taiho-to in LPS-activated RAW 264.7 cells,a murine macrophage cell line / Am J Chin Med 28 : 217~226

[journal] Cyster JG / 1999 / Chemokines and cell migration in secondary lymphoid organs / Science 286(5447) : 2098~2102

[journal] Dutton RW / 1998 / T cell memory / Annu Rev Immnol 16 : 201~223

[journal] Kupper TS / 2000 / T cells, immnonsurveillance, and cutaneous immunity / J Dermatol Sci 24 : S41~S45

KJCKorea
Journal Central

Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42