Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42
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pISSN : 1226-4075 / eISSN : 2287-786X
- https://journal.kci.go.kr/JSCM
KJCKorea
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Beneficial Effect of Hyangsayangwi-tang on the Cisplatin-Induced Gastrointestinal Dysfunctions in Rats
- Journal of Sasang Constitution and Immune Medicine
- Abbr : J Sasang Constitut Med
- 2013, 25(4), pp.343-358
- DOI : 10.7730/JSCM.2013.25.4.343
- Publisher : The Society of Sasang Constitution and Immune Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
Seo Eun Hee 1, Kim Seongtae 2, Nayoung， Bae 3, 최애련 1
1대구한의대학교
2대구한의대학교 한의과대학 사상체질과
3부산대학교
Accredited
ABSTRACT
Objectives This study aimed to observe the effect of Hyangsayangwi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats.
Methods Four groups(each of 8 rats per group) were used in this study. Saline and distilled water treated control rats are Intact vehicle control group. Delayed gatrointestinal mortility was induced by intraperitoneal treatment of cisplatin 2㎎/㎏, once a week for 5 weeks(Cisplatin control group). Hyangsayangwi-tang aqueous extracts(HY) were orally administered in a volume of 5㎖/㎏, once a day for 14 days from 4th ciplatin treatmernt(HY group). Ondansetron 1㎎/㎏ was subcutaneously treated, in a volume of 1㎖/㎏, as same as HY(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA, GSH contents and SOD, CAT activities, TPH and MAO activities, pyloric gastrin and serotonin contents with their immunoraective cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon.
Results and Conclusions (1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in HY, ondansetron group.
(2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in HY, ondansetron group.
(3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in HY group.
(4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased in HY group. And the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in HY group.
(5) The pyloru atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of HY.HY, a representative Soeumin prescription improve GI dysfunctions and constipation retarded by cisplatin through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems. Especially HY showed the highest favorable effects more than those of ondansetron.
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[journal]
Kishibayashi N
/ 1993
/ Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, inrats:inhibition of the distal colonic function
/ Jpn J Pharmacol
63(4)
: 495~502
[journal]
Lebwohl D
/ 1998
/ Clinical development of platinum complexes in cancer therapy: an historical perspective and an update
/ Eur J Cancer
34(10)
: 1522~1534
[journal]
Andrews PL
/ 2006
/ Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
/ Auton Neurosci
125(1-2)
: 100~115
[journal]
Martin C
/ 1998
/ Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation
/ Radiat Res
149(6)
: 631~636
[journal]
Hafermann MJ
/ 2011
/ Effect of intravenous ondansetron on QT interval prolongation in patients with cardiovascular disease and additional risk factors for torsades: a prospective, observational study
/ Drug Healthc Patient Saf
3
: 53~58
[journal]
김진철
/ 2005
/
Inhibitory Effects of Sophora flavescens on the Hepatic & Renal Side Effects of Chemotherapy by Cisplatin
/ Korean Journal of Acupuncture
/ 경락경혈학회
22(3)
: 165~174
[journal]
남주영
/ 2009
/
Increasing Effects of Apoptosis When Co-treated Scutellaria barbata D. Don. with Anti-cancer Drugs
/ 대한한방부인과학회지
/ 대한한방부인과학회
22(1)
: 125~139
[journal]
김현경
/ 2006
/
Effects of cell growth inhibition on the combination of cisplatin with green tea extracts
/ Journal of Gynecologic Oncology
/ 대한부인종양학회
17(4)
: 347~353
[journal]
Rho YS
/ 1998
/ Preventive Effect of Crude Drug Preparation (E-kong-san) on Cisplatin induced Nephrotoxicity
/ Kor. J. Pharmacogn
29(3)
: 258~264
[journal]
조수인
/ 2003
/
Beneficial Effect of Nodus Nelumbinis Rhizomatis Extract on Cisplatin-Induced Kidney Toxicity n Rats
/ 대한본초학회지
/ 대한본초학회
18(4)
: 16~134
[journal]
안창범
/ 2002
/
Beneficial Effect of Scutellaria Balicalensis Georgi. Extract (SBGE) on Cisplatin-Induced Acute Renal Failure in Rabbits
/ 대한침구의학회지
/ 대한침구의학회
19(3)
: 156~167
[journal]
조시용
/ 2005
/
The Effect of Plantaginis Semen Herbal Acupuncture on Acute Renal Failure in Rat
/ Korean Journal of Acupuncture
/ 경락경혈학회
22(4)
: 117~127
[book]
Lee JM
/ 2002
/ Donguisusebowon
/ Eulyoo Publishing Co., Ltd
: 27~278
[book]
Institute for Laboratory Animal Research
/ 1985
/ Guide for the Care and Use of Laboratory Animals
/ The national academics press
: 162~166
[journal]
Tyers MB
/ 1991
/ 5-HT3 receptors and the therapeuticpotential of 5-HT3 receptor antagonists
/ Therapie (Paris)
46(6)
: 431~435
[journal]
Chirino YI
/ 2009
/ Role of oxidative and nitrosative stress in cisplatin induced nephrotoxicity
/ Exp Toxicol Pathol
61(3)
: 223~242
[journal]
Chang B
/ 2002
/ L-Carnitine inhibits cisplatin induced injury of the kidney and small intestine
/ Arch Biochem Biophys
405(1)
: 55~64
[journal]
SM Ahn
/ 1994
/ Anti-Emetic Efficacy of Ondansetron Plus Desamethasone in Cisplatin- Based Combination Chemotherapy
/ Korean Journal of Obstetrics and Gynecology
37(5)
: 976~994
[journal]
Malik NM
/ 2007
/ Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats
/ Eur J Pharmacol
555(2-3)
: 164~173
[journal]
Martin C
/ 1998
/ Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation
/ Radiat Res
149(6)
: 631~636
[journal]
Badary OA
/ 2006
/ In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats
/ World J Gastroenterol
12(33)
: 5363~5367
[journal]
Kim YB
/ 1998
/ A Randomized Comparison of Tropisetron versus Ondansetron in the Control of Nausea and Vomiting in Gynecologic Cancer Patients Undergone Cisplatin- Based Chemotherapy
/ Korean Journal of Obstetrics and Gynecology
41(10)
: 2544~2550
[book]
National federation of department of sasang constitutional medicine
/ 2004
/ Sasang constitutional medicine
/ Jipmoondang
: 260~480
[journal]
한경석
/ 2006
/
The Study on the Formative Process of Soeumin Pharmacology-Focused on Gabobon and Sinchukbon-
/ 사상체질의학회지
/ 사상체질의학회
18(2)
: 15~24
[journal]
Kim KY
/ 1992
/ The Theoretical Analysis on Soeumin-Hyangsayangwi-tang
/ J Sasang Constitut Med
4(1)
: 213~219
[journal]
Kim KY
/ 1989
/ An Experimental Study on Some Effects of Soeumin-Hyangsayangwi-tang
/ J Sasang Constitut Med
1(1)
: 153~170
[journal]
최병철
/ 2008
/
Anti-Oxidant Effect of Hyangsayangyi-tang Decoction in Stomach, Spleen and Pancreas cell of SD Rats
/ 사상체질의학회지
/ 사상체질의학회
20(2)
: 72~84
[journal]
Wintola OA
/ 2010
/ The effect of Aloeferox Mill. in the treatment of loperamide-induced constipationin Wistarrats
/ BMC Gastroenterol
10
: 95~
[journal]
Sagar L
/ 2005
/ Evaluation of antimotility effect of Lantanacamara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice
/ BMC Complement Altern Med
5
: 18~
[journal]
Yang ZH
/ 2008
/ Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model
/ PLoS One
3(10)
: e3348~
[journal]
Comporti M.
/ 1985
/ Lipid peroxidation and cellular damage in toxic liver injury
/ Lab Invest
53(6)
: 599~623
[journal]
Odabasoglu F
/ 2006
/ Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats
/ J Ethnopharmacol
103(1)
: 59~65
[journal]
Cheeseman KH
/ 1993
/ An introduction to free radical biochemistry
/ Br Med Bull
49(3)
: 481~493
[journal]
Süleyman H
/ 2009
/ Comparative study on the gastroprotective potential of some antidepressants in indomethacininduced ulcer in rats
/ Chem Biol Interact
180(2)
: 318~324
[journal]
Lee HS
/ 2010
/ Regional distribution and relative frequency of gastrointestinal endocrine cells in the ddN mice: an immunohistochemical study
/ Anat Histol Embryol
39(6)
: 521~528
[journal]
Bradner WT
/ 1981
/ Toxicology screening in small animals
/ Cancer Treat Rev
8(2)
: 93~102
[journal]
Wang Y
/ 2000
/ Role of vitamin d on the inhibition of gastrin production after Cisplatin treatment
/ Met Based Drugs
7(3)
: 115~119
[journal]
Gershon MD
/ 1981
/ Release of endogenous 5-hydroxytryptamine from resting and stimulated enteric neurons
/ Neuroscience
6(11)
: 2277~2286
[book]
Lee GN
/ 1993
/ File of Clinical Pathology
/ Medical Culture
: 526~527
[journal]
Huh So
/ 1994
/ A 6.1 kb 5' upstream region of the mouse tryptophan hydroxylase gene directs expression of E, coli lacZ to major serotonergic brain region and pineal pland in transgenic mice
/ Brain Res Mol Brain Res
24(1-4)
: 145~152
[book]
Lee JC
/ 2003
/ New Sasang Constitutional Medicine 2
/ Wood and Earth
: 79~249