The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity (赤小豆 外皮(Phaseolus angularis shell)의 고지방식이로 유도된 비만 동물모델에서 항비만, 항고지혈증 효과)

jinyoung kwak (곽진영); PARK JUNGHWAN (박정환); Young-Mee Koh (고영미); Jung-Mi Park (박정미); TaekWon ahn (안택원)

doi:10.7730/JSCM.2017.29.2.136

The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity

Journal of Sasang Constitution and Immune Medicine
Abbr : J Sasang Constitut Med
2017, 29(2), pp.136-153
DOI : 10.7730/JSCM.2017.29.2.136
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine
Published : June 30, 2017

jinyoung kwak ¹, PARK JUNGHWAN ¹, Young-Mee Koh ¹, Jung-Mi Park ², TaekWon ahn ²

¹대전대학교부속한방병원
²대전대학교

Accredited

ABSTRACT

Objectives This experimental study was designed to investigate the effect of Phaseolus angularis shell on metabolic syndrome. Methods Each 5 C57BL/6J mice were randomly assigned to normal diet group, high-fat diet(HFD) control group, high-fat diet plus 15.6 mg/kg/day of Orlistat(HFD-Orlistat) group, high-fat diet plus 100mg/kg/day of Phaseolus angularis shell extract(HFD-PAS_E) group. Weight, the blood chemical and hematologic parameter was med. The mRNA expression was assayed through Reverse transcriptase polymerase chain reaction(RT-PCR). Results In HFD-PAS_E group, the body weight gain, weight of liver, and the level of LDL-Cholesterol were significantly decreased and the level of HDL-Cholesterol were significantly increased. The size of adipocyte in HFD-PAS_E group was smaller than HFD group’s. In HFD-PAS_E group, the expression of leptin, PPAR-γ, AP2/FABP4 mRNA in liver adipocyte tissue was decreased, the expression of Adiponectin, UCP-2 mRNA in liver adipocyte tissue was increased and the expression of Leptin, C/EBP-a, AP2/FABP4 mRNA in epididymal adipocyte tissue was decreased. Conclusion These results suggest that Phaseolus angularis shell has inhibitory effects on metabolic syndrome by reducing the body weight and the levels of lipid contents in high-fat-diet induced obese mice.

KEYWORDS

Phaseolus angularis shell, Metabolic syndrome, Anti-obesity, anti-diabetic, Soyangin

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The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity

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* References for papers published after 2023 are currently being built.

Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42

The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity

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