Anti-atopic Effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) in DNCB-induced Atopic Dermatitis-like Skin Lesions NC/Nga Mice (천연물 유래 산조인 복합오일 (Zizyphus jujuba var. spinosa Composite oil, ZjJ-C_oil) 및 독활 복합오일 (Aralia cordata var. continentalis Composite oil, ARC-C_oil)의 DNCB로 유도된 NC/Nga 생쥐의 아토피에 미치는 효과 연구)

jinyoung kwak (곽진영); 최희정; Jung-Mi Park (박정미); PARK JUNGHWAN (박정환); Young-Mee Koh (고영미); Jang Tae Su (장태수); TaekWon ahn (안택원)

doi:10.7730/JSCM.2017.29.4.347

Anti-atopic Effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) in DNCB-induced Atopic Dermatitis-like Skin Lesions NC/Nga Mice

Journal of Sasang Constitution and Immune Medicine
Abbr : J Sasang Constitut Med
2017, 29(4), pp.347-368
DOI : 10.7730/JSCM.2017.29.4.347
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine
Published : December 31, 2017

jinyoung kwak ¹, 최희정 ², Jung-Mi Park ³, PARK JUNGHWAN ¹, Young-Mee Koh ¹, Jang Tae Su ⁴, TaekWon ahn ³

¹대전대학교부속한방병원
²차의과대학교
³대전대학교
⁴서울대학교

Accredited

ABSTRACT

The aim of this study is to investigate the effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) to NC/Nga mice induced in Atopic dermatitis-like skin lesions by DNCB. NC/Nga mice which have been induced to Atopic dermatitis-like skin lesions by DNCB are divided into 4 groups, the first is the mice which have been spread with izyphus jujuba var. spinosa Composite oil(ZjJ-C_oil), the second is the mice which have been spread with Aralia cordata var. continentalis Composite oil(ARC-C_oil), the third is which have been spread with dexamethasone (Dexa.) 0.5% on their Atopic lesion, the last is the control group. Then We analyzed skin clinical score, blood sample of each group of measure state of the dorsal skin, the number of immunocytes, and resect the skin lesion to anlayze the state of cells. There are meaningful results of measuring the number of IgE, IL-4, IL-13, IFN-γ, IL-5, the total cells in ALN, dorsal skin, CD4+ Th, CD11b+/Gr-1+ in PBMCs, CD4+ Th, B220+/CD23+ in ALN, CD4+, CD8+ Th in dorsal skin, the level of COX-2, TNF-α, TGF-β1, IL-4, IL-13 mRNA, the state of the skin lesion and cells in the group with ZjJ-C_oil, ARC-C_oil cream in comprarison with the control group.

KEYWORDS

Atopic Dermatitis, NC/Nga Mouse, izyphus jujuba var. spinosa Composite oil(ZjJ-C_oil), Aralia cordata var. continentalis Composite oil(ARC-C_oil).

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Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42

Anti-atopic Effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) in DNCB-induced Atopic Dermatitis-like Skin Lesions NC/Nga Mice

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* References for papers published after 2023 are currently being built.

Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42

Anti-atopic Effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) in DNCB-induced Atopic Dermatitis-like Skin Lesions NC/Nga Mice

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