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@article{ART002357209},
author={SoonWoo Jang and Young-Mee Koh and jinyoung kwak and TaekWon ahn},
title={Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2018},
volume={30},
number={2},
pages={8-27},
doi={10.7730/JSCM.2018.30.2.8}

TY - JOUR
AU - SoonWoo Jang
AU - Young-Mee Koh
AU - jinyoung kwak
AU - TaekWon ahn
TI - Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2018
VL - 30
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 8
EP - 27
SN - 1226-4075
AB - Objective This study investigated the effects of Jeoreongchajeonja-tang in a high-fat diet-induced obesity mouse model. Methods The study examined 9-week-old male mice (C57bl/6J) divided into four groups: the normal(C57bl/6J-Nr), control (high-fat diet only; HFD-CTL), positive-control (high-fat diet with Garcinia cambogia), and experimental (high-fat diet with Jeoreongchajeonja-tang; HFD-JCT) groups. After 7 weeks, the body weight, food efficiency ratio, organ weight, and visceral fat weight of the mice were measured. Blood serum tests, mRNA, liver histopathology, and epididymis adipocytes were also examined. Results Compared with the Control(HFD-CTL) group, the Experimental(HFD-JCT) group given Jeoreongchajeonja-tang showed significant reductions in absolute body weight and food efficiency ratio. The serum alanine aminotransferase, total-cholesterol, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, insulin-like growth factor-1, and leptin levels were significantly lower in the experimental group than in the control group. The serum adiponectin levels were significantly higher in the experimental group than in the control group. Compared with the control group, the experimental group showed significant reductions in absolute abdominal subcutaneous fat, epididymal adipose tissue, kidney adipose tissue, intestine adipose tissue, and liver, kidney and spleen adipose tissue weights. The C/EBP-β, leptin, and SREBP1c/ADD1 mRNA expression were significantly lower in the experimental group than in the control group, while the UCP-2 and adiponectin mRNA expression were significantly higher. Compared with the control group, the experimental group showed a significant reduction in the absolute adipocyte area in the liver and epididymal adipose tissue. Conclusion Jeoreongchajeonja-tang has an anti-obesity effect. Additional clinical studies are expected.
KW - Obesity;Jeoreongchajeonja-tang;obesity mouse model;cholesterol
DO - 10.7730/JSCM.2018.30.2.8
ER -

SoonWoo Jang, Young-Mee Koh, jinyoung kwak and TaekWon ahn. (2018). Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model. Journal of Sasang Constitution and Immune Medicine, 30(2), 8-27.

SoonWoo Jang, Young-Mee Koh, jinyoung kwak and TaekWon ahn. 2018, "Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model", Journal of Sasang Constitution and Immune Medicine, vol.30, no.2 pp.8-27. Available from: doi:10.7730/JSCM.2018.30.2.8

SoonWoo Jang, Young-Mee Koh, jinyoung kwak, TaekWon ahn "Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model" Journal of Sasang Constitution and Immune Medicine 30.2 pp.8-27 (2018) : 8.

SoonWoo Jang, Young-Mee Koh, jinyoung kwak, TaekWon ahn. Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model. 2018; 30(2), 8-27. Available from: doi:10.7730/JSCM.2018.30.2.8

SoonWoo Jang, Young-Mee Koh, jinyoung kwak and TaekWon ahn. "Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model" Journal of Sasang Constitution and Immune Medicine 30, no.2 (2018) : 8-27.doi: 10.7730/JSCM.2018.30.2.8

SoonWoo Jang; Young-Mee Koh; jinyoung kwak; TaekWon ahn. Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model. Journal of Sasang Constitution and Immune Medicine, 30(2), 8-27. doi: 10.7730/JSCM.2018.30.2.8

SoonWoo Jang; Young-Mee Koh; jinyoung kwak; TaekWon ahn. Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model. Journal of Sasang Constitution and Immune Medicine. 2018; 30(2) 8-27. doi: 10.7730/JSCM.2018.30.2.8

SoonWoo Jang, Young-Mee Koh, jinyoung kwak, TaekWon ahn. Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model. 2018; 30(2), 8-27. Available from: doi:10.7730/JSCM.2018.30.2.8

SoonWoo Jang, Young-Mee Koh, jinyoung kwak and TaekWon ahn. "Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model" Journal of Sasang Constitution and Immune Medicine 30, no.2 (2018) : 8-27.doi: 10.7730/JSCM.2018.30.2.8