@article{ART002718612},
author={Son Sang-kon and MIN KYU SHIN and Song Il Byoung},
title={Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats},
journal={Journal of Sasang Constitutional Medicine},
issn={1226-4075},
year={2001},
volume={13},
number={2},
pages={165-176}
TY - JOUR
AU - Son Sang-kon
AU - MIN KYU SHIN
AU - Song Il Byoung
TI - Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats
JO - Journal of Sasang Constitutional Medicine
PY - 2001
VL - 13
IS - 2
PB - The Society Of Sasang Constitutional Medicine
SP - 165
EP - 176
SN - 1226-4075
AB - This study demonstrates the effects of Yanggyuksanhwa-Tang, Sasang constitutional herb prescription reported its clinical effect on the stroke of the So-yang In(少陽人), on the cerebral blood flow changes induced by nitro L-arginine methyl ester (L-NAME) treatment and ischemic brain damage induced by the middle cerebral artery occlusion (MCAO) in the rats. The changes of the arterial blood pressure, cerebral blood flow, and the diameter of the pial artery were measured in rats treated with L-NAME. And the changes of the infarct size, volume, and plasma tumor necrosis factor alpha (TNF-α) levels were measured in the rats that the middle cerebral artery has been occluded by the intraluminal suture thread method. Yanggyuksanhwa-Tang was administered by the i.v. injection on the L-NAME treated rats, by the i.o. administration on the MCAO rats.
The results is 1. The changes of the arterial blood pressure was not different statistically between in the L-NAME treated control group and in the Yanggyuksanhwa-Tang administered group.
2. Increase in the cerebral blood flow induced by L-NAME treatment was attenuated in the Yanggyuksanhwa-Tang administered group significantly (P<0.05) as compared with the L-NAME treated control group.
3. Decrease in the diameter of the pial artery induced by L-NAME treatment was attenuated about 18% in the Yanggyuksanhwa-Tang administered group as compared with the L-NAME treated control group.
4. Ischemic damaged infarct areas were decreased significantly (P<0.05) in the interaural 12mm, 10mm, and 6mm brain sections of the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group.
5. Total ischemic infarct volume was decreased significantly (P<0.05) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group.
6. Plasma TNF-α levels were decreased significantly (P<0.01) in the Yanggyuksanhwa-Tang administered group as compared the MCA occluded control group.
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Son Sang-kon, MIN KYU SHIN and Song Il Byoung. (2001). Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats. Journal of Sasang Constitutional Medicine, 13(2), 165-176.
Son Sang-kon, MIN KYU SHIN and Song Il Byoung. 2001, "Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats", Journal of Sasang Constitutional Medicine, vol.13, no.2 pp.165-176.
Son Sang-kon, MIN KYU SHIN, Song Il Byoung "Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats" Journal of Sasang Constitutional Medicine 13.2 pp.165-176 (2001) : 165.
Son Sang-kon, MIN KYU SHIN, Song Il Byoung. Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats. 2001; 13(2), 165-176.
Son Sang-kon, MIN KYU SHIN and Song Il Byoung. "Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats" Journal of Sasang Constitutional Medicine 13, no.2 (2001) : 165-176.
Son Sang-kon; MIN KYU SHIN; Song Il Byoung. Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats. Journal of Sasang Constitutional Medicine, 13(2), 165-176.
Son Sang-kon; MIN KYU SHIN; Song Il Byoung. Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats. Journal of Sasang Constitutional Medicine. 2001; 13(2) 165-176.
Son Sang-kon, MIN KYU SHIN, Song Il Byoung. Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats. 2001; 13(2), 165-176.
Son Sang-kon, MIN KYU SHIN and Song Il Byoung. "Effects of Yanggyuksanhwa-Tang(凉膈散火湯) on Cerebral Blood Flow and Ischemic Brain Damage in Rats" Journal of Sasang Constitutional Medicine 13, no.2 (2001) : 165-176.
