@article{ART002802012},
author={Lee Sookyung and Lee Seong Jin and Song Il Byoung},
title={Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2002},
volume={14},
number={2},
pages={90-97}
TY - JOUR
AU - Lee Sookyung
AU - Lee Seong Jin
AU - Song Il Byoung
TI - Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2002
VL - 14
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 90
EP - 97
SN - 1226-4075
AB - Sasang Constitutional Medicine is based on the diversity of human being and medically developed the variation of response to diseases and medicines. The diversity is categorized as four groups Taeyangin, Taeumin, Soyangin, Soeumin according to morphology, physiology, pathology, and pharmacology. The phenotypes of Sasang constitutions represent that constitutions may be possessed of the different genetic backgrounds. To clarify the genetic difference among the Sasang constitutions, we performed a genetic analysis with the 3'-UTR polymorphism of ADPRT (rs=8679) as a pooled DNA sequencing method. ADPRT modulates various nuclear proteins by poly(ADP-ribosy)lation and is involved in the regulation of various cellular processes such as differentiation, proliferation, and tumor transformation. This gene is also involved in the recovery of cell from DNA damage and the brain infarction. The allele frequencies of [T/C] polymorphism of ADPRT of Soeumin and Soyangin groups were (T: 0.94/C: 0.06) and that of Taeumin and Taeyangin groups were (T: l.00/C: 0.00). The allele frequency was not showed the difference between constitution groups. This result represented that the [T/C] polymorphism of ADPRT 3' UTR region was not suitable to classify the constitutions. However, this study is the first trial of Sasang classification according to genetic polymorphism and further analysis will be necessarily to classify the genetic difference of Sasang constitution.
KW - Sasang Constitution;Polymorphism;ADPRT;SNP
DO -
UR -
ER -
Lee Sookyung, Lee Seong Jin and Song Il Byoung. (2002). Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution. Journal of Sasang Constitution and Immune Medicine, 14(2), 90-97.
Lee Sookyung, Lee Seong Jin and Song Il Byoung. 2002, "Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution", Journal of Sasang Constitution and Immune Medicine, vol.14, no.2 pp.90-97.
Lee Sookyung, Lee Seong Jin, Song Il Byoung "Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution" Journal of Sasang Constitution and Immune Medicine 14.2 pp.90-97 (2002) : 90.
Lee Sookyung, Lee Seong Jin, Song Il Byoung. Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution. 2002; 14(2), 90-97.
Lee Sookyung, Lee Seong Jin and Song Il Byoung. "Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution" Journal of Sasang Constitution and Immune Medicine 14, no.2 (2002) : 90-97.
Lee Sookyung; Lee Seong Jin; Song Il Byoung. Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution. Journal of Sasang Constitution and Immune Medicine, 14(2), 90-97.
Lee Sookyung; Lee Seong Jin; Song Il Byoung. Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution. Journal of Sasang Constitution and Immune Medicine. 2002; 14(2) 90-97.
Lee Sookyung, Lee Seong Jin, Song Il Byoung. Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution. 2002; 14(2), 90-97.
Lee Sookyung, Lee Seong Jin and Song Il Byoung. "Genetic Polymorphism of ADPRT Gene 3´UTR Region and Sasang Constitution" Journal of Sasang Constitution and Immune Medicine 14, no.2 (2002) : 90-97.
2,
Song Il Byoung
1