@article{ART002802281},
author={Youn Bo-hyun and Park Seong-sik},
title={Yangkyuksanhwa-tang effected to Atopic Dermatitis},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2004},
volume={16},
number={2},
pages={84-98}
TY - JOUR
AU - Youn Bo-hyun
AU - Park Seong-sik
TI - Yangkyuksanhwa-tang effected to Atopic Dermatitis
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2004
VL - 16
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 84
EP - 98
SN - 1226-4075
AB - 1. Objectives Yangkyuksanhwa-tang is used mush in pruritus and dermatopathy of Soyangin. It is suggested this prescription is effective on atopy dermatitis.
2. Methods For observation of Yangkyuksanhwa-tang effected to atopic dermatitis, extract of Yangkyuksanhwa-tang has been dispensed to the stratum corneum of epithelium in dermatome of murine after making damage to its defense mechanism against fat and causing atopic dermatitis artificially. After that, the change in outer dermatome and minute mechanism of epidermis, the change of eosinophil, the change in distribution of soybean agglutinin, the change in distribution of fat and ceramide in stratum corneum, the change in inflammation in dermatome, the change of cell accrementition and apoptosis, and the effect on anaphylaxis and Staphylococcus aureus was observed.
3. Results After administration of Yangkyuksanhwa-tang, severe skin damage such as eczema and psoriasis, that was observed in the case of atopy dermatitis, was decreased and the increase of eosinophil in serum was suppressed. Lipid lamella was recovered, so epidermal demage was relieved. The distribution of HSP70 in the outer skin was decreased.
Yangkyuksanhwa-tang suppressed activation of NF-κB p50, induced CD11/18b not to be generated, and suppressed inflammatory response of skin. Anaphylaxis and groth of Staphylococcus aureus was suppressed.
4. Conclusions Yangkyuksanhwa-tang decreased skin damage of atopy dermatitis. It has antibiosis about Staphylococcus aureus, it can be medicinal substances on atopy dermatitis. In addition, it is possible that it can be medicinal substances on regional skin allergy.
KW - Yangkyuksanhwa-tang;Atopic Dermatitis;Anaphylaxis;Staphylococcus aureus;Cytokine;Apoptosis
DO -
UR -
ER -
Youn Bo-hyun and Park Seong-sik. (2004). Yangkyuksanhwa-tang effected to Atopic Dermatitis. Journal of Sasang Constitution and Immune Medicine, 16(2), 84-98.
Youn Bo-hyun and Park Seong-sik. 2004, "Yangkyuksanhwa-tang effected to Atopic Dermatitis", Journal of Sasang Constitution and Immune Medicine, vol.16, no.2 pp.84-98.
Youn Bo-hyun, Park Seong-sik "Yangkyuksanhwa-tang effected to Atopic Dermatitis" Journal of Sasang Constitution and Immune Medicine 16.2 pp.84-98 (2004) : 84.
Youn Bo-hyun, Park Seong-sik. Yangkyuksanhwa-tang effected to Atopic Dermatitis. 2004; 16(2), 84-98.
Youn Bo-hyun and Park Seong-sik. "Yangkyuksanhwa-tang effected to Atopic Dermatitis" Journal of Sasang Constitution and Immune Medicine 16, no.2 (2004) : 84-98.
Youn Bo-hyun; Park Seong-sik. Yangkyuksanhwa-tang effected to Atopic Dermatitis. Journal of Sasang Constitution and Immune Medicine, 16(2), 84-98.
Youn Bo-hyun; Park Seong-sik. Yangkyuksanhwa-tang effected to Atopic Dermatitis. Journal of Sasang Constitution and Immune Medicine. 2004; 16(2) 84-98.
Youn Bo-hyun, Park Seong-sik. Yangkyuksanhwa-tang effected to Atopic Dermatitis. 2004; 16(2), 84-98.
Youn Bo-hyun and Park Seong-sik. "Yangkyuksanhwa-tang effected to Atopic Dermatitis" Journal of Sasang Constitution and Immune Medicine 16, no.2 (2004) : 84-98.
