@article{ART002804040},
author={Park Seong Sik and Koh Byung-Hee and Song Il Byung},
title={The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={1997},
volume={9},
number={1},
pages={315-337}
TY - JOUR
AU - Park Seong Sik
AU - Koh Byung-Hee
AU - Song Il Byung
TI - The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response
JO - Journal of Sasang Constitution and Immune Medicine
PY - 1997
VL - 9
IS - 1
PB - The Society of Sasang Constitution and Immune Medicine
SP - 315
EP - 337
SN - 1226-4075
AB - In order to compare the dffects ofGalgunhaegitangGalgu˘nhaegit′ang(葛根解肌湯) of "Dongeuisusebowon(東醫壽世保元)and Won's(元)-GalgunhaegitangGalgu˘nhaegit′ang(葛根解肌湯) of "Dongeuisasansinpyun(東醫四象新編)" on the immune respone, Sprague-Dawley male rats were used and randomly divided into four groups. Normal group was under normal condition, Control group was injected i.v. with 2mg/kg Methotrexate(MTX) on the 9th day and 11th day after sensitization with SRBC on the 5th day,GalgunhaegitangGalgu˘nhaegit′anggroup was fed with 1ml ofGalgunhaegitangGalgu˘nhaegit′angand Won's-GalgunhaegitangGalgu˘nhaegit′anggroup was fed with 1ml of Won's-GalgunhaegitangGalgu˘nhaegit′angby oral during eighteen days. In the 9th day and the 11th day after oral feeding with medication, MTX was injected in tail of rats in order to reduce immune function. Leukocyte count, lymphocyte ratio, lymphocyte count of spleen, lymphocyte count of bone marrow, contact hypersensitivity to DNFB, morphologic change of thymus cell, and electropherogram of serum protein were estimated and compared according to the group. The results are as follows : 1. Before and after MTX injection, leukocyte(WBC) count was increased signigicantly in Won's-GalgunhaegitangGalgu˘nhaegit′anggroup compared to control group.GalgunhaegitangGalgu˘nhaegit′anggroup had no significant difference compared to control group. 2. Before and after MTX injection, lymphocyte ratio was not significantly different in Won's-GalgunhaegitangGalgu˘nhaegit′anggroup and inGalgunhaegitangGalgu˘nhaegit′anggroup compared to control group. 3. The lymphocyte count of spleen was increased significantly inGalgunhaegitangGalgu˘nhaegit′anggroup compared to control group and Won's-GalgunhaegitangGalgu˘nhaegit′anggroup. Won's-GalgunhaegitangGalgu˘nhaegit′anggroup had no significant difference compared to control group. 4. The lymphocyte count of bone marrow was increased significantly in Won's-GalgunhaegitangGalgu˘nhaegit′anggroup compared to control group andGalgunhaegitangGalgu˘nhaegit′anggroup.GalgunhaegitangGalgu˘nhaegit′anggroup had no significant difference compared to control group. 5. Contact hypersensitivity was increased significantly in Won's-GalgunhaegitangGalgu˘nhaegit′anggroup compared to other group.GalgunhaegitangGalgu˘nhaegit′anggroup had no significant difference compared to control groups. 6. In the morphologic change of thymus cell, control group compared to normal group had a indistinct boundary between cortex and medulla and lymphocyte cell density of thymus was low.GalgunhaegitangGalgu˘nhaegit′anggroup and Won's-GalgunhaegitangGalgu˘nhaegit′anggroup compared to control group had a definite boundary between cortex and medulla and lymphocyte cell density of thymus was high. 7. In the SDS-PAGE electropherogram of serum protein, Won's-GalgunhaegitangGalgu˘nhaegit′anggroup had a wide band of nearby 25,000 Dalton, and which meant IgG generated more actively. Considering this results,GalgunhaegitangGalgu˘nhaegit′anggroup and Won's-GalgunhaegitangGalgu˘nhaegit′anggroup have an effect on the depression of immune function induced by MTX, and especially Won's-GalgunhaegitangGalgu˘nhaegit′anggroup has an significant effect thanGalgunhaegitangGalgu˘nhaegit′anggroup.
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Park Seong Sik, Koh Byung-Hee and Song Il Byung. (1997). The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response. Journal of Sasang Constitution and Immune Medicine, 9(1), 315-337.
Park Seong Sik, Koh Byung-Hee and Song Il Byung. 1997, "The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response", Journal of Sasang Constitution and Immune Medicine, vol.9, no.1 pp.315-337.
Park Seong Sik, Koh Byung-Hee, Song Il Byung "The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response" Journal of Sasang Constitution and Immune Medicine 9.1 pp.315-337 (1997) : 315.
Park Seong Sik, Koh Byung-Hee, Song Il Byung. The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response. 1997; 9(1), 315-337.
Park Seong Sik, Koh Byung-Hee and Song Il Byung. "The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response" Journal of Sasang Constitution and Immune Medicine 9, no.1 (1997) : 315-337.
Park Seong Sik; Koh Byung-Hee; Song Il Byung. The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response. Journal of Sasang Constitution and Immune Medicine, 9(1), 315-337.
Park Seong Sik; Koh Byung-Hee; Song Il Byung. The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response. Journal of Sasang Constitution and Immune Medicine. 1997; 9(1) 315-337.
Park Seong Sik, Koh Byung-Hee, Song Il Byung. The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response. 1997; 9(1), 315-337.
Park Seong Sik, Koh Byung-Hee and Song Il Byung. "The effects of Galgŭnhaegit'ang and Won's-Galgŭnhaegit'ang for Taeŭmin on the immune response" Journal of Sasang Constitution and Immune Medicine 9, no.1 (1997) : 315-337.
