@article{ART002804076},
author={Na, Dal-Rye and kim kyung yo and Lee Jong Duck},
title={Study on the Toxicity of Jihwangbakhotang in Rats},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={1997},
volume={9},
number={2},
pages={203-225}
TY - JOUR
AU - Na, Dal-Rye
AU - kim kyung yo
AU - Lee Jong Duck
TI - Study on the Toxicity of Jihwangbakhotang in Rats
JO - Journal of Sasang Constitution and Immune Medicine
PY - 1997
VL - 9
IS - 2
PB - The Society of Sasang Constitution and Immune Medicine
SP - 203
EP - 225
SN - 1226-4075
AB - Jihwangbakhotang(地黃白虎楊) is made by Li Je Ma, the creator of the Four Constitutional Medicine. Single and 13 weeks oral repeated dose toxicity studies were conducted in Sprague Dawley rats of both sexes to elucidate the potential acute and subchronic toxicity of JBT extract and reversibility of any effects. In the single dose study, JBT extract was administered orally to rats with the dose of 2 g/kg and 8 g/kg. In the long term administration of 13 weeks, the JBT extract of 125 mg/kg/day, 500 mg/kg/day, 2000 mg/kg/day was administered to rats. The change of blood weight, urine volume, electrolyte in urine, hematological change, the change of blood chemistry, autopsy finding, and histological observation were researched, the results were as follows; 1. The lethal dose of JBT extract seems to be over 10 g/kg, the single administration of JBT extract 8 g/kg showed no toxical signs except little increase of urine volume. 2. The change of body weight had the trend of decrease in the group of, but has no significance, and also the consumption of food and water had no changes. 3. The hematological changes induced by the 13 weeks administration of JBT extract showed the significance in the item of Hb, MCH, MCV, WBC in the group of 125 mg/kg/day. 4. In the test of blood chemistry, total cholesterol showed little decrease and A/G ratio showed little increase, but the change was not clear, and the standard error was large. So the result was obtained insignificantly and the toxicity of JBT extract was not observed. 5. In the male group after recovery period, the level of cholesterol and triglyceride decreased slightly, but the result was not significant. 6. In the urine test, the little change of electrolyte was appeared, but it seemed not to be the result induced by the toxicity of JBT extract. 7. In each group of male and female rats, the weight change of organ and the serum histological changes was observed, but the result did not showed the dose dependent toxicity. So the toxicity of JBT extract was not regarded. In the conclusion, the toxicity of JBT extract was not observed in the single dose treatment and long term repetitive administration of JBT extract.
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Na, Dal-Rye, kim kyung yo and Lee Jong Duck. (1997). Study on the Toxicity of Jihwangbakhotang in Rats. Journal of Sasang Constitution and Immune Medicine, 9(2), 203-225.
Na, Dal-Rye, kim kyung yo and Lee Jong Duck. 1997, "Study on the Toxicity of Jihwangbakhotang in Rats", Journal of Sasang Constitution and Immune Medicine, vol.9, no.2 pp.203-225.
Na, Dal-Rye, kim kyung yo, Lee Jong Duck "Study on the Toxicity of Jihwangbakhotang in Rats" Journal of Sasang Constitution and Immune Medicine 9.2 pp.203-225 (1997) : 203.
Na, Dal-Rye, kim kyung yo, Lee Jong Duck. Study on the Toxicity of Jihwangbakhotang in Rats. 1997; 9(2), 203-225.
Na, Dal-Rye, kim kyung yo and Lee Jong Duck. "Study on the Toxicity of Jihwangbakhotang in Rats" Journal of Sasang Constitution and Immune Medicine 9, no.2 (1997) : 203-225.
Na, Dal-Rye; kim kyung yo; Lee Jong Duck. Study on the Toxicity of Jihwangbakhotang in Rats. Journal of Sasang Constitution and Immune Medicine, 9(2), 203-225.
Na, Dal-Rye; kim kyung yo; Lee Jong Duck. Study on the Toxicity of Jihwangbakhotang in Rats. Journal of Sasang Constitution and Immune Medicine. 1997; 9(2) 203-225.
Na, Dal-Rye, kim kyung yo, Lee Jong Duck. Study on the Toxicity of Jihwangbakhotang in Rats. 1997; 9(2), 203-225.
Na, Dal-Rye, kim kyung yo and Lee Jong Duck. "Study on the Toxicity of Jihwangbakhotang in Rats" Journal of Sasang Constitution and Immune Medicine 9, no.2 (1997) : 203-225.
