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@article{ART002943589},
author={jinyoung kwak and Won-Kyung Yang and Seung Hyung Kim and In Chul Jung and Yang-Chun Park and TaekWon ahn},
title={Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold},
journal={Journal of Sasang Constitutional Medicine},
issn={1226-4075},
year={2023},
volume={35},
number={1},
pages={14-24}

TY - JOUR
AU - jinyoung kwak
AU - Won-Kyung Yang
AU - Seung Hyung Kim
AU - In Chul Jung
AU - Yang-Chun Park
AU - TaekWon ahn
TI - Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold
JO - Journal of Sasang Constitutional Medicine
PY - 2023
VL - 35
IS - 1
PB - The Society Of Sasang Constitutional Medicine
SP - 14
EP - 24
SN - 1226-4075
AB - Objectives This study was conducted to observe physiological changes when the function of spleen was extremely deteriorated, and to make an animal model with spleen deficiency. Methods The Normal group (Nr group) was not administered with Senna Folium extract. The SFE group(Senna Folium extract group) was administered with Senna Folium extract every day for the first 2 weeks and then every other day for another week. And the SFE_G group(Senna Folium extract_Ginseng group) was also administered with Senna Folium for 3weeks like the SFE group and fed with ginseng in the third week. Results The score of spleen deficiency was significantly higher in SFE group than in the Nr group and significantly lower in the SFE_G group than in the SFE group. The total weight gain was significantly lower in the SFE group than in the Nr group, and the average daily weight gain was significantly lower in the SFE group than in the Nr group. The difference in stool weight before and after the process of drying was significantly higher in the SFE group than in the Nr group, and significantly lower in the SFE-G group than the SFE group. There was no significant difference in the outcomes related to cold and heat among the three groups. Conclusions Through this study, the animal model with spleen deficiency was developed to prepare a stepping stone for animal tests to verify the efficacy and safety of constitutional prescriptions.
KW - Spleen dificiency;Soeum-in;animal model;Sasang Constitutional Medicine;heat and cold
DO -
UR -
ER -

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park and TaekWon ahn. (2023). Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold. Journal of Sasang Constitutional Medicine, 35(1), 14-24.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park and TaekWon ahn. 2023, "Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold", Journal of Sasang Constitutional Medicine, vol.35, no.1 pp.14-24.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park, TaekWon ahn "Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold" Journal of Sasang Constitutional Medicine 35.1 pp.14-24 (2023) : 14.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park, TaekWon ahn. Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold. 2023; 35(1), 14-24.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park and TaekWon ahn. "Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold" Journal of Sasang Constitutional Medicine 35, no.1 (2023) : 14-24.

jinyoung kwak; Won-Kyung Yang; Seung Hyung Kim; In Chul Jung; Yang-Chun Park; TaekWon ahn. Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold. Journal of Sasang Constitutional Medicine, 35(1), 14-24.

jinyoung kwak; Won-Kyung Yang; Seung Hyung Kim; In Chul Jung; Yang-Chun Park; TaekWon ahn. Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold. Journal of Sasang Constitutional Medicine. 2023; 35(1) 14-24.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park, TaekWon ahn. Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold. 2023; 35(1), 14-24.

jinyoung kwak, Won-Kyung Yang, Seung Hyung Kim, In Chul Jung, Yang-Chun Park and TaekWon ahn. "Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold" Journal of Sasang Constitutional Medicine 35, no.1 (2023) : 14-24.