Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold (비기능 저하 동물 모델 개발과 한열변화 관찰)

jinyoung kwak (곽진영); Won-Kyung Yang (양원경); Seung Hyung Kim (김승형); In Chul Jung (정인철); Yang-Chun Park (박양춘); TaekWon ahn (안택원)

Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold

Journal of Sasang Constitution and Immune Medicine
Abbr : J Sasang Constitut Med
2023, 35(1), pp.14-24
Publisher : The Society of Sasang Constitution and Immune Medicine
Research Area : Medicine and Pharmacy > Korean Medicine
Received : February 6, 2023
Accepted : March 8, 2023
Published : March 31, 2023

jinyoung kwak ¹, Won-Kyung Yang ², Seung Hyung Kim ², In Chul Jung ³, Yang-Chun Park ⁴, TaekWon ahn ⁵

¹대전대학교 한의과대학 사상체질의학교실
²대전대학교 동서생명과학연구원
³대전대학교 한의과대학
⁴대전대학교 한의과대학 내과학교실
⁵대전대학교

Accredited

ABSTRACT

Objectives This study was conducted to observe physiological changes when the function of spleen was extremely deteriorated, and to make an animal model with spleen deficiency. Methods The Normal group (Nr group) was not administered with Senna Folium extract. The SFE group(Senna Folium extract group) was administered with Senna Folium extract every day for the first 2 weeks and then every other day for another week. And the SFE_G group(Senna Folium extract_Ginseng group) was also administered with Senna Folium for 3weeks like the SFE group and fed with ginseng in the third week. Results The score of spleen deficiency was significantly higher in SFE group than in the Nr group and significantly lower in the SFE_G group than in the SFE group. The total weight gain was significantly lower in the SFE group than in the Nr group, and the average daily weight gain was significantly lower in the SFE group than in the Nr group. The difference in stool weight before and after the process of drying was significantly higher in the SFE group than in the Nr group, and significantly lower in the SFE-G group than the SFE group. There was no significant difference in the outcomes related to cold and heat among the three groups. Conclusions Through this study, the animal model with spleen deficiency was developed to prepare a stepping stone for animal tests to verify the efficacy and safety of constitutional prescriptions.

KEYWORDS

Spleen dificiency, Soeum-in, animal model, Sasang Constitutional Medicine, heat and cold

Citation status

* References for papers published after 2023 are currently being built.

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This paper was written with support from the National Research Foundation of Korea.

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Journal of Sasang Constitution and Immune Medicine 2023 KCI Impact Factor : 0.42