Electro-responsive Transdermal Drug Release of MWCNT/PVA Nanocomposite Hydrogels

김연이; 윤주미; Lee, Young-Seak (이영석); Kim， Hyung-il (김형일)

Electro-responsive Transdermal Drug Release of MWCNT/PVA Nanocomposite Hydrogels

Carbon Letters
Abbr : Carbon Lett.
2010, 11(3), pp.211-215
Publisher : Korean Carbon Society
Research Area : Natural Science > Natural Science General > Other Natural Sciences General

김연이 ¹, 윤주미 ¹, Lee, Young-Seak ¹, Kim， Hyung-il ¹

¹충남대학교

Candidate

ABSTRACT

Multi-walled carbon nanotube (MWCNT)/poly(vinyl alcohol) (PVA) nanocomposite hydrogels were prepared by freezingthawing method for the electro-responsive transdermal drug delivery. MWCNTs were used as the functional ingredient to improve both mechanical and electrical properties of MWCNT/PVA nanocomposite hydrogels. The morphology of nanocomposites revealed the uniform distribution of MWCNTs and the good interfacial contact. The compression moduli of hydrogel matrices increased greatly from 40 to 1500 kPa by forming MWCNT/PVA nanocomposites. The swelling ratio of MWCNT/PVA nanocomposites decreased as the content of MWCNTs increased under no electric voltage applied. However,the swelling ratio of MWCNT/PVA nanocomposites increased as the content of MWCNTs increased under electric voltage applied and the applied electric voltage increased. The drug was released in the electro-responsive manner through the skin due to the electro-sensitive swelling characteristics of MWCNT/PVA nanocomposite hydrogels.

KEYWORDS

Transdermal drug delivery, Hydrogel, Carbon nanotubes, Electro-responsive, Nanocomposite

Citation status

* References for papers published after 2023 are currently being built.

[journal] Langer, R. / 2004 / / Adv. Drug Delivery Rev. 56 : 557~

[journal] Prausnitz, M. R. / 2004 / / Nat. Rev. Drug Discovery 3 : 115~

[journal] Murdan, S. / 2003 / / J. Control. Release 92 : 1~

[journal] Gudeman, L. F. / 1995 / / J. Membr. Sci. 107 : 239~

[journal] Xu, F. / 2006 / / Biomaterials 27 : 2787~

[journal] Chien, Y. W. / 1990 / / J. Control. Release 13 : 263~

[journal] Mohammad, M. / 2006 / / Macromolecules 39 : 5194~

[journal] Daoush, W. M / 2009 / / Mat. Sci. Eng. A 513 : 247~

[journal] Miuík, M. / 2009 / / J. Appl. Polym. Sci. 113 : 2536~

[journal] Shen, Z. / 2009 / / J. Compos. Sci. Technol. 69 : 239~

[journal] Bianco, A. / 2005 / / Curr. Opin. Chem. Biol. 9 : 674~

[journal] Davis, J. J. / 2003 / / Chem. Eur. J. 9 : 3732~

[journal] Scranton, A. B. / 1995 / / J. Adv. Polym. Sci. 122 : 1~

[journal] Bell, C. L. / 1995 / / J. Adv. Polym. Sci. 122 : 126~

[journal] Stauffer, S. R. / 1992 / / J. Polym. 33 : 3932~

[journal] Hassan, C. M. / 2000 / / J. Adv. Polym. Sci. 153 : 37~

[journal] 오애리 / 2009 / Effect of pH-dependent Solubility on Release Behavior of Alginate-Chitosan Blend Containing Activated Carbon / Carbon Letters / 한국탄소학회 10(3) : 208~212

[journal] Kim, S. Y. / 1999 / / J. Appl. Polym. Sci. 74 : 1752~

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