@article{ART002220448},
author={Jia Ren and Xiaogang Zhang and Yao Chen},
title={Graphene accelerates osteoblast attachment and biomineralization},
journal={Carbon Letters},
issn={1976-4251},
year={2017},
volume={22},
pages={42-47}
TY - JOUR
AU - Jia Ren
AU - Xiaogang Zhang
AU - Yao Chen
TI - Graphene accelerates osteoblast attachment and biomineralization
JO - Carbon Letters
PY - 2017
VL - 22
IS - null
PB - Korean Carbon Society
SP - 42
EP - 47
SN - 1976-4251
AB - In this paper, the in vitro biocompatibility of graphene film (GF) with osteoblasts was evaluated through cell adhesion, viability, alkaline phosphatase activity, F-actin and vinculin expressions, versus graphite paper as a reference material. The results showed that MG-63 cells exhibited stronger cell adhesion, better proliferation and viability on GF, and osteoblasts cultured on GF exhibited vinculin expression throughout the cell body. The rougher and wrinkled surface morphology, higher elastic modulus and easy out-of-plane deformation associated with GF were considered to promote cell adhesion. Also, the biomineralization of GF was assessed by soaking in simulated body fluid, and the GF exhibited enhanced mineralization ability in terms of mineral deposition, which almost pervaded the entire GF surface. Our results suggest that graphene promotes cell adhesion, activity and the formation of bonelike apatite. This research is expected to facilitate a better understanding of graphene-cell interactions and potential applications of graphene as a promising toughening nanofiller in bioceramics used in load-bearing implants.
KW - graphene film;osteoblast;adhesion;viability;mineralization
DO -
UR -
ER -
Jia Ren, Xiaogang Zhang and Yao Chen. (2017). Graphene accelerates osteoblast attachment and biomineralization. Carbon Letters, 22, 42-47.
Jia Ren, Xiaogang Zhang and Yao Chen. 2017, "Graphene accelerates osteoblast attachment and biomineralization", Carbon Letters, vol.22, pp.42-47.
Jia Ren, Xiaogang Zhang, Yao Chen "Graphene accelerates osteoblast attachment and biomineralization" Carbon Letters 22 pp.42-47 (2017) : 42.
Jia Ren, Xiaogang Zhang, Yao Chen. Graphene accelerates osteoblast attachment and biomineralization. 2017; 22 42-47.
Jia Ren, Xiaogang Zhang and Yao Chen. "Graphene accelerates osteoblast attachment and biomineralization" Carbon Letters 22(2017) : 42-47.
Jia Ren; Xiaogang Zhang; Yao Chen. Graphene accelerates osteoblast attachment and biomineralization. Carbon Letters, 22, 42-47.
Jia Ren; Xiaogang Zhang; Yao Chen. Graphene accelerates osteoblast attachment and biomineralization. Carbon Letters. 2017; 22 42-47.
Jia Ren, Xiaogang Zhang, Yao Chen. Graphene accelerates osteoblast attachment and biomineralization. 2017; 22 42-47.
Jia Ren, Xiaogang Zhang and Yao Chen. "Graphene accelerates osteoblast attachment and biomineralization" Carbon Letters 22(2017) : 42-47.
