@article{ART002372185},
author={Shou-Cang Shen and Wai Kiong Ng and Kumaran Letchmanan and Ron Tau Yee Lim and Reginald Beng Hee Tan},
title={Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate},
journal={Carbon Letters},
issn={1976-4251},
year={2018},
volume={27},
number={1},
pages={18-25},
doi={10.5714/CL.2018.27.018}
TY - JOUR
AU - Shou-Cang Shen
AU - Wai Kiong Ng
AU - Kumaran Letchmanan
AU - Ron Tau Yee Lim
AU - Reginald Beng Hee Tan
TI - Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate
JO - Carbon Letters
PY - 2018
VL - 27
IS - 1
PB - Korean Carbon Society
SP - 18
EP - 25
SN - 1976-4251
AB - In this study, graphene oxide(GO) was used as drug carriers to amorphize poorly watersoluble drugs via a co-spray drying process. Two poorly water-soluble drugs, fenofibrate and ibuprofen, were investigated. It was found that the drug molecules could be in the graphene nanosheets in amorphous or nano crystalline forms and thus have a significantly enhanced dissolution rate compared with the counterpart crystalline form. In addition, the dissolution of the amorphous drug enwrapped with the graphene oxide was higher than that of the amorphous drug in activated carbon (AC) even though the AC possessed a larger specific surface area than that of the graphene oxide. The amorphous formulations also remained stable under accelerated storage conditions (40°C and 75% relative humidity) for a study period of 14 months. Therefore, graphene oxide could be a potential drug carrier and amorphization agent for poorly water-soluble drugs to enhance their bioavailability.
KW - graphene oxide;capsulation;dissolution rate;crystallinity;physical stability
DO - 10.5714/CL.2018.27.018
ER -
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim and Reginald Beng Hee Tan. (2018). Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. Carbon Letters, 27(1), 18-25.
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim and Reginald Beng Hee Tan. 2018, "Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate", Carbon Letters, vol.27, no.1 pp.18-25. Available from: doi:10.5714/CL.2018.27.018
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim, Reginald Beng Hee Tan "Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate" Carbon Letters 27.1 pp.18-25 (2018) : 18.
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim, Reginald Beng Hee Tan. Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. 2018; 27(1), 18-25. Available from: doi:10.5714/CL.2018.27.018
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim and Reginald Beng Hee Tan. "Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate" Carbon Letters 27, no.1 (2018) : 18-25.doi: 10.5714/CL.2018.27.018
Shou-Cang Shen; Wai Kiong Ng; Kumaran Letchmanan; Ron Tau Yee Lim; Reginald Beng Hee Tan. Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. Carbon Letters, 27(1), 18-25. doi: 10.5714/CL.2018.27.018
Shou-Cang Shen; Wai Kiong Ng; Kumaran Letchmanan; Ron Tau Yee Lim; Reginald Beng Hee Tan. Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. Carbon Letters. 2018; 27(1) 18-25. doi: 10.5714/CL.2018.27.018
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim, Reginald Beng Hee Tan. Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate. 2018; 27(1), 18-25. Available from: doi:10.5714/CL.2018.27.018
Shou-Cang Shen, Wai Kiong Ng, Kumaran Letchmanan, Ron Tau Yee Lim and Reginald Beng Hee Tan. "Graphene nanosheets encapsulated poorly soluble drugs with an enhanced dissolution rate" Carbon Letters 27, no.1 (2018) : 18-25.doi: 10.5714/CL.2018.27.018
