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A nonenzymatic laser-induced flexible amperometric graphene electrode for glucose detection in saliva

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2023, 33(6), pp.1767-1780
  • DOI : 10.1007/s42823-023-00489-0
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : November 29, 2022
  • Accepted : February 28, 2023
  • Published : October 1, 2023

Nugba Betty Edem 1 El-Moneim A. A. 2 Mousa Nahla O. 3 Osman Ahmed 1

1Biotechnology Program, Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology, Borg Al Arab City, P.O. Box 179, Alexandria, Egypt
2Graphene Center of Excellence for Energy and Electronics Applications, Egypt-Japan University of Science and Technology, Borg Al Arab City, P.O. Box 179, Alexandria, Egypt
3Faculty of Science, Cairo University, Giza, Egypt

Accredited

ABSTRACT

Graphene is a suitable transducer for wearable sensors because of its high conductivity, large specific surface area, flexibility, and other unique considerable features. Using a simple, fast galvanic pulse electrodeposition approach, a unique nonenzymatic glucose amperometric electrode was successfully developed based on well-distributed fine Cu nanoparticles anchored on the surface of 3D structure laser-induced graphene. The fabricated electrode allows glucose detection with a sensitivity of 2665 µA/mM/cm2, a response time of less than 5 s, a linear range of 0.03–4.5 mM, and a LOD of 0.023 µM. It also detects glucose selectively in the presence of interfering species such as ascorbic acid and urea. These provide the designed electrode the advantages for glucose sensing in saliva with 97% accuracy and present it among the best saliva-range non-enzymatic glucose sensors reported to date for real-life diagnostic applications.

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