A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

Chen Junnan; Yu Lingmin; Xu Wenzhen; Lin Tao; Jiang Sicong; Jin Caijin

doi:10.1007/s42823-023-00560-w

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

Carbon Letters
Abbr : Carbon Lett.
2023, 33(6), pp.1811-1817
DOI : 10.1007/s42823-023-00560-w
Publisher : Korean Carbon Society
Research Area : Natural Science > Natural Science General > Other Natural Sciences General
Received : April 11, 2023
Accepted : June 14, 2023
Published : October 1, 2023

Chen Junnan ¹, Yu Lingmin ², Xu Wenzhen ¹, Lin Tao ¹, Jiang Sicong ³, Jin Caijin ¹

¹Department of Cardio-Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China
²Sanmen County Medical Emergency Center, 171 Renmin Road, Sanmen County, Taizhou, Zhejiang, China
³Division of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva, 1211, Geneva 4, Switzerland

Accredited

ABSTRACT

Graphene-based sensors have emerged as significant tools for biosensing applications due to their unique electrical, mechanical, and thermal properties. In this study, we have developed an innovative and sensitive aptasensor based on the surface-modified graphene for the detection of lung cancer biomarker CA125. The sensor leverages the combination of graphene surface and gold nanoparticles (AuNPs) electrodeposition to achieve a high level of sensitivity and selectivity for the biomarker detection. A noticeable decrease in electron transfer resistance was observed upon the AuNPs deposition, demonstrating the enhancement of electrochemical performance. Our experimental findings showed a strong linear relationship between the sensor response and CA125 concentrations, ranging from 0.2 to 15.0 ng/mL, with a detection limit of 0.085 ng/mL. This study presents a novel approach to lung cancer detection, surpassing the traditional methods in terms of invasiveness, cost, and accuracy. The results from this work could pave the way for the development of graphene-based sensors in various other biosensing applications.

KEYWORDS

Lung cancer CA125 Graphene Electrochemical sensor Aptasensor

Citation status

This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

Total Citation Counts(KCI+WOS) (3) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (2) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-07-01)

* References for papers published after 2023 are currently being built.

[journal] Khalid MAU / 2020 / A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment / Biochem Eng J 155 : 107469~

[journal] Kovalska E / 2019 / Multi-layer graphene as a selective detector for future lung cancer biosensing platforms / Nanoscale 11 : 2476~2483

[journal] Ramanathan S / 2019 / Multidimensional(0D–3D)nanostructures for lung cancer biomarker analysis : comprehensive assessment on current diagnostics / Biosens Bioelectron 141 : 111434~

[journal] Liu J / 2019 / Novel molecularly imprinted polymer(MIP)multiple sensors for endogenous redox couples determination and their applications in lung cancer diagnosis / Talanta 199 : 573~580

[journal] Li W / 2020 / Recognizing lung cancer using a homemade e-nose : a comprehensive study / Comput Biol Med 120 : 103706~

[journal] Yu L / 2019 / A ratiometric electrochemical sensor for multiplex detection of cancer biomarkers using bismuth as an internal reference and metal sulfide nanoparticles as signal tags / Analyst 144 : 4073~4080

[journal] Biswas S / 2021 / Label-free electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 125 based on antibody-immobilized biocompatible MOF-808/CNT / ACS Appl Mater Interfaces 13 : 3295~3302

[journal] Rebelo TS / 2019 / Molecularly imprinted polymer SPE sensor for analysis of CA-125 on serum / Anal Chim Acta 1082 : 126~135

[journal] Attia M / 2019 / Phthalocyanine-doped polystyrene fluorescent nanocomposite as a highly selective biosensor for quantitative determination of cancer antigen 125 / Talanta 201 : 185~193

[journal] Charkhchi P / 2020 / CA125 and ovarian cancer : a comprehensive review / Cancers 12 : 3730~

[journal] Wang X / 2022 / Four-protein model for predicting prognostic risk of lung cancer / Front Med 16 : 618~626

[journal] Njoku K / 2022 / Urine CA125 and HE4 for the triage of symptomatic women with suspected endometrial cancer / Cancers 14 : 3306~

[journal] Foroozandeh A / 2023 / An electrochemical aptasensor based on g-C3N4/Fe3O4/PANI nanocomposite applying cancer antigen_125 biomarkers detection / Process Biochem 127 : 82~91

[journal] Zhang F / 2022 / A label-free electrochemical aptasensor for the detection of cancer antigen 125 based on nickel hexacyanoferrate nanocubes/polydopamine functionalized graphene / J Electroanal Chem 918 : 116424~

[journal] Ni Y / 2022 / Label-free electrochemical aptasensor based on magnetic α-Fe2O3/Fe3O4 heterogeneous hollow nanorods for the detection of cancer antigen 125 / Bioelectrochemistry 148 : 108255~

[journal] Chen M / 2021 / Antifouling aptasensor based on self-assembled loop-closed peptides with enhanced stability for CA125 assay in complex biofluids / Anal Chem 93 : 13555~13563

[journal] Pourmadadi M / 2023 / Application of various optical and electrochemical nanobiosensors for detecting cancer antigen 125(CA-125) : a review / Biosensors 13 : 99~

[journal] Wang Q / 2021 / Graphene oxide quantum dots based nanotree illuminates AFB1 : dual signal amplified aptasensor detection AFB1 / Sens Actuators B Chem 345 : 130387~

[journal] Fan Y / 2022 / Smartphone-based electrochemical system with multi-walled carbon nanotubes/thionine/gold nanoparticles modified screen-printed immunosensor for cancer antigen 125 detection / Microchem J 174 : 107044~

[journal] Bharti A / 2020 / An electrochemical aptasensor for analysis of MUC1 using gold platinum bimetallic nanoparticles deposited carboxylated graphene oxide / Anal Chim Acta 1097 : 186~195

[journal] Ahmadi A / 2021 / Impedimetric paper-based enzymatic biosensor using electrospun cellulose acetate nanofiber and reduced graphene oxide for detection of glucose from whole blood / IEEE Sens J 21 : 9210~9217

[journal] Bao Y / 2022 / Molybdenum(IV)sulfide nanosheet-based aptasensor for the label-free determination of bisphenol A(BPA)by electrochemical impedance spectroscopy(EIS) / Anal Lett 55 : 1971~1979

[journal] AmouzadehTabrizi M / 2022 / An electrochemical impedance spectroscopy-based aptasensor for the determination of SARS-CoV-2-RBD using a carbon nanofiber–gold nanocomposite modified screen-printed electrode / Biosensors 12 : 142~

[journal] Ahmadi SF / 2022 / Monitoring of Aflatoxin M1 in milk using a novel electrochemical aptasensor based on reduced graphene oxide and gold nanoparticles / Food Chem 373 : 131321~

[journal] Jalalvand AR / 2019 / Fabrication of a novel and ultrasensitive label-free electrochemical aptasensor for detection of biomarker prostate specific antigen / Int J Biol Macromol 126 : 1065~1073

[journal] Hosseinzadeh L / 2020 / Advances in aptasensor technology / Adv Clin Chem 99 : 237~279

[journal] Lu Q / 2020 / Selection of aptamers specific for DEHP based on ssDNA library immobilized SELEX and development of electrochemical impedance spectroscopy aptasensor / Molecules 25 : 747~

[journal] Hou Y / 2022 / Development of a label-free electrochemical aptasensor for ultrasensitive detection of ochratoxin A / Food Control 135 : 108833~

[journal] Tao D / 2019 / Development of a label-free electrochemical aptasensor for the detection of Tau381 and its preliminary application in AD and non-AD patients’ sera / Biosensors 9 : 84~

[journal] Yen Y-K / 2020 / A graphene-PEDOT : PSS modified paper-based aptasensor for electrochemical impedance spectroscopy detection of tumor marker / Sensors 20 : 1372~

[journal] Wang X / 2016 / A 3D electrochemical immunodevice based on an Au paper electrode and using Au nanoflowers for amplification / New J Chem 40 : 2835~2842

[journal] Gedi V / 2018 / Sensitive on-chip detection of cancer antigen 125 using a DNA aptamer/carbon nanotube network platform / Sens Actuators B Chem 256 : 89~97

[journal] Hamd-Ghadareh S / 2017 / An amplified comparative fluorescence resonance energy transfer immunosensing of CA125 tumor marker and ovarian cancer cells using green and economic carbon dots for bio-applications in labeling, imaging and sensing / Biosens Bioelectron 96 : 308~316

[journal] Jin H / 2017 / Aptamer and 5-fluorouracil dual-loading Ag2S quantum dots used as a sensitive label-free probe for near-infrared photoluminescence turn-on detection of CA125 antigen / Biosens Bioelectron 92 : 378~384

KJCKorea
Journal Central

Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 4.82

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

ABSTRACT

KEYWORDS

Citation status

This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

Total Citation Counts(KCI+WOS) (3) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (2) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-07-01)

* References for papers published after 2023 are currently being built.

Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 4.82

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

WoS Citation Counts (3) This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

Total Citation Counts(KCI+WOS) (3) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (2) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-07-01)

REFERENCES (34) * References for papers published after 2023 are currently being built.

Search PDF

Citation

This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

* References for papers published after 2023 are currently being built.