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A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2023, 33(6), pp.1811-1817
  • DOI : 10.1007/s42823-023-00560-w
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : April 11, 2023
  • Accepted : June 14, 2023
  • Published : October 1, 2023

Chen Junnan 1 Yu Lingmin 2 Xu Wenzhen 1 Lin Tao 1 Jiang Sicong 3 Jin Caijin 1

1Department of Cardio-Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China
2Sanmen County Medical Emergency Center, 171 Renmin Road, Sanmen County, Taizhou, Zhejiang, China
3Division of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva, 1211, Geneva 4, Switzerland

Accredited

ABSTRACT

Graphene-based sensors have emerged as significant tools for biosensing applications due to their unique electrical, mechanical, and thermal properties. In this study, we have developed an innovative and sensitive aptasensor based on the surface-modified graphene for the detection of lung cancer biomarker CA125. The sensor leverages the combination of graphene surface and gold nanoparticles (AuNPs) electrodeposition to achieve a high level of sensitivity and selectivity for the biomarker detection. A noticeable decrease in electron transfer resistance was observed upon the AuNPs deposition, demonstrating the enhancement of electrochemical performance. Our experimental findings showed a strong linear relationship between the sensor response and CA125 concentrations, ranging from 0.2 to 15.0 ng/mL, with a detection limit of 0.085 ng/mL. This study presents a novel approach to lung cancer detection, surpassing the traditional methods in terms of invasiveness, cost, and accuracy. The results from this work could pave the way for the development of graphene-based sensors in various other biosensing applications.

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