A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

Chen Junnan; Yu Lingmin; Xu Wenzhen; Lin Tao; Jiang Sicong; Jin Caijin

doi:10.1007/s42823-023-00560-w

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

Carbon Letters
Abbr : Carbon Lett.
2023, 33(6), pp.1811-1817
DOI : 10.1007/s42823-023-00560-w
Publisher : Korean Carbon Society
Research Area : Natural Science > Natural Science General > Other Natural Sciences General
Received : April 11, 2023
Accepted : June 14, 2023
Published : October 1, 2023

Chen Junnan ¹, Yu Lingmin ², Xu Wenzhen ¹, Lin Tao ¹, Jiang Sicong ³, Jin Caijin ¹

¹Department of Cardio-Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China
²Sanmen County Medical Emergency Center, 171 Renmin Road, Sanmen County, Taizhou, Zhejiang, China
³Division of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva, 1211, Geneva 4, Switzerland

Accredited

ABSTRACT

Graphene-based sensors have emerged as significant tools for biosensing applications due to their unique electrical, mechanical, and thermal properties. In this study, we have developed an innovative and sensitive aptasensor based on the surface-modified graphene for the detection of lung cancer biomarker CA125. The sensor leverages the combination of graphene surface and gold nanoparticles (AuNPs) electrodeposition to achieve a high level of sensitivity and selectivity for the biomarker detection. A noticeable decrease in electron transfer resistance was observed upon the AuNPs deposition, demonstrating the enhancement of electrochemical performance. Our experimental findings showed a strong linear relationship between the sensor response and CA125 concentrations, ranging from 0.2 to 15.0 ng/mL, with a detection limit of 0.085 ng/mL. This study presents a novel approach to lung cancer detection, surpassing the traditional methods in terms of invasiveness, cost, and accuracy. The results from this work could pave the way for the development of graphene-based sensors in various other biosensing applications.

KEYWORDS

Lung cancer CA125 Graphene Electrochemical sensor Aptasensor

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Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 6.04

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

ABSTRACT

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Scopus Citation Counts (4) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-10-01)

* References for papers published after 2023 are currently being built.

Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 6.04

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125

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WoS Citation Counts (3) This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

Total Citation Counts(KCI+WOS) (3) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (4) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-10-01)

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