Modified screen-printed electrochemical biosensor design compatible with mobile phones for detection of miR-141 used to pancreatic cancer biomarker

Bekmezci Muhammed; Bayat Ramazan; Akin Merve; Coguplugil Zeynep Kazel; Sen Fatih

doi:10.1007/s42823-023-00545-9

Modified screen-printed electrochemical biosensor design compatible with mobile phones for detection of miR-141 used to pancreatic cancer biomarker

Carbon Letters
Abbr : Carbon Lett.
2023, 33(6), pp.1863-1873
DOI : 10.1007/s42823-023-00545-9
Publisher : Korean Carbon Society
Research Area : Natural Science > Natural Science General > Other Natural Sciences General
Received : March 10, 2023
Accepted : May 23, 2023
Published : October 1, 2023

Bekmezci Muhammed ¹, Bayat Ramazan ¹, Akin Merve ¹, Coguplugil Zeynep Kazel ¹, Sen Fatih ¹

¹SRG Incorporated Company, Kutahya Design Technopole, Calca OSB Neighbourhood, 431000, Kütahya, Turkey

Accredited

ABSTRACT

MicroRNAs (miRNAs) are emerging materials as ideal biomarkers for noninvasive cancer detection in the early phase. In this article, a simple and label-free electrochemical miRNA biosensor was developed. A single-stranded DNA (ss-DNA) probes were successfully mapped to f-MWCNT and hybridized with the target miR-141 sequence. The optimum peak points of the obtained hybridization were determined using Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) methods. Significant peaks were observed in the results, depending on miR-141 at different concentrations. The linear relationship (ν) between redox peak currents (Ip) and scanning rate indicated that electron transfer (ET) between miR-141 and the electrode surface was accomplished successfully. In DPV measurements, miR-141 was measured with a low detection limit (LOD) in the 1.3–12 nM concentration range, and the LOD and limit of quantification (LOQ) results were found to be 3 and 9.1 pM, respectively. Besides, selectivity test was investigated for the biosensor using different target analytes and a significant difference in value was observed between the peak currents of miR-141, and other target molecules. This developed strategy has been found to detect miR-141 sensitively, selectively and without tags, and its integration into mobile devices has been successfully carried out.

KEYWORDS

Cancer detection Electrochemical biosensor f-MWCNT microRNA-141

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Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 4.82

Modified screen-printed electrochemical biosensor design compatible with mobile phones for detection of miR-141 used to pancreatic cancer biomarker

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This is the result of checking the information with the same ISSN, publication year, volume, and start page between the WoS and the KCI journals. (as of 2024-07-26)

Total Citation Counts(KCI+WOS) (4) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (5) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-07-01)

* References for papers published after 2023 are currently being built.

Carbon Letters 2023 KCI Impact Factor : 1.35 KCI-WoS Impact Factor : 4.82

Modified screen-printed electrochemical biosensor design compatible with mobile phones for detection of miR-141 used to pancreatic cancer biomarker

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Total Citation Counts(KCI+WOS) (4) This is the number of times that the duplicate count has been removed by comparing the citation list of WoS and KCI.

Scopus Citation Counts (5) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-07-01)

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