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Design, synthesis and biological studies of tetrazole fused imidazopyridines

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2024, 34(1), pp.41-49
  • DOI : 10.1007/s42823-023-00603-2
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : June 27, 2023
  • Accepted : August 29, 2023
  • Published : February 1, 2024

Reddy Banoth 1 Taneja Amit Kumar 2 Tej Mandava Bhuvan 3 Navya Sri Komati 3 Tej Mandava Bhagya 3 Vijayavardhini Suryadevara 4 Srilaxmi Dandamudi 5 Tiruveedhula Somasekhar 6 Penumutchu Srinivasa Rao 6 Rao Mandava V. Basaveswara 1

1인도 안드라프라데시주 마치리파트남 크리슈나 대학교
2Chaudhary Charan Singh University
3인도 안드라프라데시주 군투르 치나카카니 NRI 의학 아카데미 MBBS학과
4Amrita Sai Institute of Science and Technology
5Dhanekula Institute of Engineering and Technology
6인도, 500100, Telangana, Hyderabad, Dhulapally, St. Martin's Engineering College, 과학 및 인문학과

Accredited

ABSTRACT

New tetrazole fused imidazopyridine derivatives (12a–j) were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds 12 h and 12j demonstrated strong anticancer activity bearing IC50 values 1.44 µM and 1.33 µM against A549 cell line.

Citation status

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