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Synthesis, applications in therapeutics, and bioimaging of traditional Chinese medicine-derived carbon dots

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2024, 34(2), pp.545-564
  • DOI : 10.1007/s42823-023-00615-y
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : June 16, 2023
  • Accepted : October 14, 2023
  • Published : March 28, 2024

Guo Susu 1 Zhang Ran 1 Liu Yingyu 1 Zhang Qingmei 2 Liu Xiaoming 1 Wu Xiuping 1 Li Bing 1

1Shanxi Medical University School and Hospital of Stomatology
2Taiyuan University of Science and Technology, Taiyuan

Accredited

ABSTRACT

Carbon dots (CDs) are a novel type of fluorescent nanoparticles with a particle size smaller than 10 nm. They possess several advantageous properties, including excellent biocompatibility, light stability, water solubility, and low toxicity. CDs have been widely researched in recent years. As a treasure of ancient Chinese science, traditional Chinese medicine (TCM) is rich in various active ingredients and has a variety of pharmacodynamic effects, which have been used for thousands of years. TCM-CDs prepared with TCM as carbon source can create some special functions and then may play a greater medicinal value. The purpose of this review was to engage in an in-depth conversation about the use of TCM-CDs in medical therapy and bioimaging. Firstly, this study provides a comprehensive exploration of different synthesis methods for TCM-CDs, comparing their respective advantages and disadvantages. Subsequently, the intrinsic pharmacological activity of TCM-CDs, encompassing antibacterial, hypoglycemic, hemostatic, anticancer, and anti-inflammatory effects, is mainly discussed, alongside their underlying mechanisms of action. Additionally, investigations into in vitro imaging of diverse cell types and the distribution and uptake of TCM-CDs under in vivo imaging guidance are presented. Finally, the significance of TCM-CD research, key challenges and issues within this field, and future directions for development are summarized and outlined.

Citation status

Scopus Citation Counts (1) This is the result of checking the information with the same ISSN, publication year, volume, and start page between articles in KCI and the SCOPUS journals. (as of 2024-10-01)

* References for papers published after 2023 are currently being built.