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Carbon nanomaterials: a promising avenue in colorectal cancer treatment

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2024, 34(8), pp.2035-2053
  • DOI : 10.1007/s42823-024-00805-2
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : March 5, 2024
  • Accepted : August 20, 2024
  • Published : December 5, 2024

Ramezani Farani Marzieh 1 Lak Mandana 2 C. Cho William 3 Kang Haneul 4 Azarian Maryam 5 Yazdian Fatemeh 6 Harirchi Sharareh 7 Khoshmaram Keyvan 6 Alipourfard Iraj 8 Hushmandi Kiavash 6 Hwang Seung-Kyu 4 HUH YUN SUK 4

1Inha University
2Alzahra University
3Queen Elizabeth Hospital
4인하대학교
5Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany
6University of Tehran
7Department of Biotechnology, Iranian Research Organization for Science and Technology
8Institute of Physical Chemistry, Polish Academy of Science

Accredited

ABSTRACT

Colorectal cancer (CRC) poses a signifcant global public health challenge, accounting for 10% of newly diagnosed cancer cases and causing 9.4% of cancer-related deaths. Conventional treatment methods like surgery, chemotherapy, and radiation have shown limited success despite the increasing incidence of CRC. Thus, there is an urgent need for innovative thera- peutic approaches. Researchers are continually working on developing novel technologies, notably focused on the creation of safe and efective cancer nanomedicines, in their continuous efort to advance cancer treatment. Nanoparticles exist at the nanoscale. Nanoparticles at the nanoscale have distinctive properties that leverage the metabolic disparities between cancerous and normal cells. This property allows them to selectively induce substantial cytotoxicity in cancer cells while minimizing damage to healthy tissue. Carbon nanomaterials (CNMs), including graphene oxide (GO), carbon nanotubes (CNTs), and nanodiamonds (NDs), have undergone extensive investigation due to their biocompatibility, surface-to-volume ratio, thermal conductivity, rigid structural properties, and ability for post-chemical modifcations. Notably, GO has emerged as a promising two-dimensional (2D) material for cancer treatment. Several groundbreaking nanoparticle-based therapies, predominantly utilizing GO, are currently undergoing clinical trials, with some already gaining regulatory clearance

Citation status

* References for papers published after 2023 are currently being built.

This paper was written with support from the National Research Foundation of Korea.