본문 바로가기
  • Home

Development of a graphene-based bimetallic catalyst for enhanced voltammetric detection of sulfafurazole antimicrobial agents

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2025, 35(4), pp.1667~1675
  • DOI : 10.1007/s42823-025-00882-x
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : October 22, 2024
  • Accepted : February 7, 2025
  • Published : December 11, 2025

Nejad Mohammad Khazaei 1 Zamani Hassan Ali 1

1Islamic Azad University

Accredited

ABSTRACT

This research developed a highly efficient voltammetric sensor, utilizing a carbon paste electrode (CPE) integrated with a novel ZnO-doped Pd–Pt bimetallic catalyst decorated with reduced graphene oxide (ZnO-Pt@Pd/rGO) and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([EMIM][Tf2N]), for the precise determination of sulfafurazole in real dextrose saline and tablet samples. The ZnO-Pt@Pd/rGO nanocomposite was synthesized through a one-stage synthesis process and characterized using SEM and EDS techniques. The comparison of the ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE with unmodified CPE, ZnO-Pt@Pd/rGO/CPE, and [EMIM][Tf2N]/CPE confirms the synergic effect of ZnO-Pt@Pd/rGO and [EMIM][Tf2N] as two conductive catalysts in fabrication of new sensor. The resulting sensor exhibited remarkable stability over a period of 2 months without compromising its efficiency for sulfafurazole detection. With a linear range of 0.001–250 µM (R2 = 0.9971) and LOD of 0.4 nM, ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE showcased exceptional accuracy and precision in the monitoring of sulfafurazole. Validation using real tablet and dextrose saline samples confirmed the sensor's outstanding capability in determining sulfafurazole, with relative recoveries ranging from 98.92 to 103.8% offering a promising solution for reliable sulfafurazole analysis in diverse pharmaceutical samples.

Citation status

* References for papers published after 2024 are currently being built.