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@article{ART003273391},
author={Caifeng Ren and Yanrong Zhou and Yuan Wu and Liurong Fang and Jiangong Liang and Shaobo Xiao},
title={The conversion of tannic acid into carbon dots enhances its antiviral activities},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={4},
pages={1795-1809},
doi={10.1007/s42823-025-00910-w}

TY - JOUR
AU - Caifeng Ren
AU - Yanrong Zhou
AU - Yuan Wu
AU - Liurong Fang
AU - Jiangong Liang
AU - Shaobo Xiao
TI - The conversion of tannic acid into carbon dots enhances its antiviral activities
JO - Carbon Letters
PY - 2025
VL - 35
IS - 4
PB - Korean Carbon Society
SP - 1795
EP - 1809
SN - 1976-4251
AB - Tannic acid (TA) is one of the active components in the Galla Chinensis and has various effects, including antioxidant and anti-inflammatory properties. However, research on its antiviral properties remains limited. Here, tannic acid carbon dots (TA-CDs) were prepared as potential antiviral drugs from polyphenol TA under different temperature conditions (180, 200, 220 and 240 °C). Compared to TA alone, TA-CDs exhibited lower cytotoxicity and a tenfold enhanced in antiviral activity. Additionally, the antiviral effects of TA-CDs varied with preparation temperatures, with the best effect observed at 200 °C (CDs-2), reaching a titer of 2.8 orders of magnitude in porcine reproductive and respiratory syndrome virus (PRRSV), mainly due to its relatively higher number of functional groups and smaller particle size. Mechanically, CDs-2 was shown to inhibit PRRSV by targeting the stages of inactivation, adsorption, invasion, replication, and down-regulating reactive oxygen species (ROS) levels. Moreover, CDs-2 exhibited a high inhibitory effect on porcine epidemic diarrhea virus (PEDV), reaching a titer of 7 orders of magnitude. This study reveals the importance of temperature in synthesis of traditional Chinese medicine-derived carbon dots (TCM-CDs) and confirms their potential as antiviral drugs, providing valuable information for development of TCM antiviral drugs.
KW - Tannic acid carbon dots;Antiviral;Porcine reproductive and respiratory syndrome virus;Porcine epidemic diarrhea virus;Antiviral mechanism
DO - 10.1007/s42823-025-00910-w
ER -

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang and Shaobo Xiao. (2025). The conversion of tannic acid into carbon dots enhances its antiviral activities. Carbon Letters, 35(4), 1795-1809.

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang and Shaobo Xiao. 2025, "The conversion of tannic acid into carbon dots enhances its antiviral activities", Carbon Letters, vol.35, no.4 pp.1795-1809. Available from: doi:10.1007/s42823-025-00910-w

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang, Shaobo Xiao "The conversion of tannic acid into carbon dots enhances its antiviral activities" Carbon Letters 35.4 pp.1795-1809 (2025) : 1795.

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang, Shaobo Xiao. The conversion of tannic acid into carbon dots enhances its antiviral activities. 2025; 35(4), 1795-1809. Available from: doi:10.1007/s42823-025-00910-w

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang and Shaobo Xiao. "The conversion of tannic acid into carbon dots enhances its antiviral activities" Carbon Letters 35, no.4 (2025) : 1795-1809.doi: 10.1007/s42823-025-00910-w

Caifeng Ren; Yanrong Zhou; Yuan Wu; Liurong Fang; Jiangong Liang; Shaobo Xiao. The conversion of tannic acid into carbon dots enhances its antiviral activities. Carbon Letters, 35(4), 1795-1809. doi: 10.1007/s42823-025-00910-w

Caifeng Ren; Yanrong Zhou; Yuan Wu; Liurong Fang; Jiangong Liang; Shaobo Xiao. The conversion of tannic acid into carbon dots enhances its antiviral activities. Carbon Letters. 2025; 35(4) 1795-1809. doi: 10.1007/s42823-025-00910-w

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang, Shaobo Xiao. The conversion of tannic acid into carbon dots enhances its antiviral activities. 2025; 35(4), 1795-1809. Available from: doi:10.1007/s42823-025-00910-w

Caifeng Ren, Yanrong Zhou, Yuan Wu, Liurong Fang, Jiangong Liang and Shaobo Xiao. "The conversion of tannic acid into carbon dots enhances its antiviral activities" Carbon Letters 35, no.4 (2025) : 1795-1809.doi: 10.1007/s42823-025-00910-w