@article{ART003274557},
author={Arefina Irina A. and Stepanidenko Evgeniia A. and German Sergey V. and Nikiforova Margarita V. and Cvjetinovic Julijana and Sergeeva Kseniia A. and Marusich Elena I. and Yashchenok Alexey M. and Cherevkov Sergei A. and Ushakova Elena V. and Rogach Andrey L.},
title={Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={6},
pages={3047-3057},
doi={10.1007/s42823-025-00976-6}
TY - JOUR
AU - Arefina Irina A.
AU - Stepanidenko Evgeniia A.
AU - German Sergey V.
AU - Nikiforova Margarita V.
AU - Cvjetinovic Julijana
AU - Sergeeva Kseniia A.
AU - Marusich Elena I.
AU - Yashchenok Alexey M.
AU - Cherevkov Sergei A.
AU - Ushakova Elena V.
AU - Rogach Andrey L.
TI - Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting
JO - Carbon Letters
PY - 2025
VL - 35
IS - 6
PB - Korean Carbon Society
SP - 3047
EP - 3057
SN - 1976-4251
AB - Multimodal composites have the potential to play a crucial role in the development of theranostic agents. Systems with optical and magnetic response can be applied in medicine for both imaging and therapy; however, combining magnetic and luminescent nanoparticles in one entity is challenging. Both the morphology and architecture of the composite, as well as the influence of the magnetic components and matrix on the light-emissive component, must be paid attention. In this study, we demonstrate a design of a composite with advantageous magnetic response and luminescence in green and red regions (excited at 405 and 580 nm, respectively), where biocompatible CaCO3 microspheres were loaded and decorated with luminescent carbon dots (CDs) and magnetite nanoparticles (MNPs). We showed the absence of CDs’ toxicity by the IC50 tests and demonstrated its localization in L1 and L4 stages of C. elegans embryogenesis. We determine the optimal parameters for composite formation to achieve their improved performance and structural stability. The composites were fabricated in several steps, including loading nanoparticles and layer-by-layer application of polyelectrolytes on top of CaCO3. We demonstrated the applicability of the prepared composite microspheres for flow cytometry and showed their potential as multiplexed visualization agents, emphasizing their potential use as promising theranostic agents.
KW - Carbon dots;Magnetite;Calcium carbonate microspheres;Luminescence;Theranostics
DO - 10.1007/s42823-025-00976-6
ER -
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V. and Rogach Andrey L.. (2025). Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters, 35(6), 3047-3057.
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V. and Rogach Andrey L.. 2025, "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting", Carbon Letters, vol.35, no.6 pp.3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V., Rogach Andrey L. "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35.6 pp.3047-3057 (2025) : 3047.
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V., Rogach Andrey L.. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. 2025; 35(6), 3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V. and Rogach Andrey L.. "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35, no.6 (2025) : 3047-3057.doi: 10.1007/s42823-025-00976-6
Arefina Irina A.; Stepanidenko Evgeniia A.; German Sergey V.; Nikiforova Margarita V.; Cvjetinovic Julijana; Sergeeva Kseniia A.; Marusich Elena I.; Yashchenok Alexey M.; Cherevkov Sergei A.; Ushakova Elena V.; Rogach Andrey L.. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters, 35(6), 3047-3057. doi: 10.1007/s42823-025-00976-6
Arefina Irina A.; Stepanidenko Evgeniia A.; German Sergey V.; Nikiforova Margarita V.; Cvjetinovic Julijana; Sergeeva Kseniia A.; Marusich Elena I.; Yashchenok Alexey M.; Cherevkov Sergei A.; Ushakova Elena V.; Rogach Andrey L.. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters. 2025; 35(6) 3047-3057. doi: 10.1007/s42823-025-00976-6
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V., Rogach Andrey L.. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. 2025; 35(6), 3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Arefina Irina A., Stepanidenko Evgeniia A., German Sergey V., Nikiforova Margarita V., Cvjetinovic Julijana, Sergeeva Kseniia A., Marusich Elena I., Yashchenok Alexey M., Cherevkov Sergei A., Ushakova Elena V. and Rogach Andrey L.. "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35, no.6 (2025) : 3047-3057.doi: 10.1007/s42823-025-00976-6
