@article{ART003274557},
author={Irina A. Arefina and Evgeniia A. Stepanidenko and Sergey V. German and Margarita V. Nikiforova and Julijana Cvjetinovic and Kseniia A. Sergeeva and Elena I. Marusich and Alexey M. Yashchenok and Sergei A. Cherevkov and Elena V. Ushakova and Andrey L. Rogach},
title={Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting},
journal={Carbon Letters},
issn={1976-4251},
year={2025},
volume={35},
number={6},
pages={3047-3057},
doi={10.1007/s42823-025-00976-6}
TY - JOUR
AU - Irina A. Arefina
AU - Evgeniia A. Stepanidenko
AU - Sergey V. German
AU - Margarita V. Nikiforova
AU - Julijana Cvjetinovic
AU - Kseniia A. Sergeeva
AU - Elena I. Marusich
AU - Alexey M. Yashchenok
AU - Sergei A. Cherevkov
AU - Elena V. Ushakova
AU - Andrey L. Rogach
TI - Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting
JO - Carbon Letters
PY - 2025
VL - 35
IS - 6
PB - Korean Carbon Society
SP - 3047
EP - 3057
SN - 1976-4251
AB - Multimodal composites have the potential to play a crucial role in the development of theranostic agents. Systems with optical and magnetic response can be applied in medicine for both imaging and therapy; however, combining magnetic and luminescent nanoparticles in one entity is challenging. Both the morphology and architecture of the composite, as well as the influence of the magnetic components and matrix on the light-emissive component, must be paid attention. In this study, we demonstrate a design of a composite with advantageous magnetic response and luminescence in green and red regions (excited at 405 and 580 nm, respectively), where biocompatible CaCO3 microspheres were loaded and decorated with luminescent carbon dots (CDs) and magnetite nanoparticles (MNPs). We showed the absence of CDs’ toxicity by the IC50 tests and demonstrated its localization in L1 and L4 stages of C. elegans embryogenesis. We determine the optimal parameters for composite formation to achieve their improved performance and structural stability. The composites were fabricated in several steps, including loading nanoparticles and layer-by-layer application of polyelectrolytes on top of CaCO3. We demonstrated the applicability of the prepared composite microspheres for flow cytometry and showed their potential as multiplexed visualization agents, emphasizing their potential use as promising theranostic agents.
KW - Carbon dots;Magnetite;Calcium carbonate microspheres;Luminescence;Theranostics
DO - 10.1007/s42823-025-00976-6
ER -
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova and Andrey L. Rogach. (2025). Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters, 35(6), 3047-3057.
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova and Andrey L. Rogach. 2025, "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting", Carbon Letters, vol.35, no.6 pp.3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova, Andrey L. Rogach "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35.6 pp.3047-3057 (2025) : 3047.
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova, Andrey L. Rogach. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. 2025; 35(6), 3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova and Andrey L. Rogach. "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35, no.6 (2025) : 3047-3057.doi: 10.1007/s42823-025-00976-6
Irina A. Arefina; Evgeniia A. Stepanidenko; Sergey V. German; Margarita V. Nikiforova; Julijana Cvjetinovic; Kseniia A. Sergeeva; Elena I. Marusich; Alexey M. Yashchenok; Sergei A. Cherevkov; Elena V. Ushakova; Andrey L. Rogach. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters, 35(6), 3047-3057. doi: 10.1007/s42823-025-00976-6
Irina A. Arefina; Evgeniia A. Stepanidenko; Sergey V. German; Margarita V. Nikiforova; Julijana Cvjetinovic; Kseniia A. Sergeeva; Elena I. Marusich; Alexey M. Yashchenok; Sergei A. Cherevkov; Elena V. Ushakova; Andrey L. Rogach. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. Carbon Letters. 2025; 35(6) 3047-3057. doi: 10.1007/s42823-025-00976-6
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova, Andrey L. Rogach. Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting. 2025; 35(6), 3047-3057. Available from: doi:10.1007/s42823-025-00976-6
Irina A. Arefina, Evgeniia A. Stepanidenko, Sergey V. German, Margarita V. Nikiforova, Julijana Cvjetinovic, Kseniia A. Sergeeva, Elena I. Marusich, Alexey M. Yashchenok, Sergei A. Cherevkov, Elena V. Ushakova and Andrey L. Rogach. "Carbon Dot-Magnetite Nanoparticle Composites in CaCO₃ Microspheres for Multiplexed Bioimaging and Magnetic Targeting" Carbon Letters 35, no.6 (2025) : 3047-3057.doi: 10.1007/s42823-025-00976-6
