CELLMED 2023 KCI Impact Factor : 0.02
-
pISSN : 3022-6805 / eISSN : 3022-6791
- https://journal.kci.go.kr/cellmed
KJCKorea
Journal Central
The use of natural remedies to treat osteoarthritis
- CELLMED
- Abbr : CellMed
- 2016, 6(1), pp.1-1
- Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
- Research Area : Medicine and Pharmacy > General Medicine
Boon Hooi Tan 1, Chin Eng Ong 2
1International Medical University
2Monash University Malaysia
Candidate
ABSTRACT
Osteoarthritis (OA) is the leading medical condition for which patients use alternative treatments including the natural remedies. The aim of this review is to describe the dietary supplements and herbal remedies most commonly used in patients with osteoarthritis with an emphasis on the efficacy and safety of these natural remedies. Glucosamine and chondroitin sulfate, two of the molecular building blocks found in articular cartilage, are the most commonly used remedies in OA treatment. Most clinical researches suggest that glucosamine and chondroitin show efficacy in reducing or improving symptoms and their ability to arrest progression of the disease or regenerate damaged cartilage. Patented formulations of both remedies are recommended by several therapeutic guidelines for use as first line background OA treatment. Reliable evidence that the combination is more effective than either agent alone is however still lacking. Several other herbs or remedies are promoted for treating osteoarthritis such as S-adenosylmethionine, methylsulfonylmethane, Harpagophytum procumbens (devil’s claw), Curcuma longa (turmeric), Zingiber officinale (ginger), and capsaicin but there is no reliable evidence on long-term efficacy or safety. The clinical usefulness of these remedies is therefore rather limited currently.
Statistics
-
404 Viewed
-
44 Downloaded
Tools
Issue List
Citation status
* References for papers published after 2023 are currently being built.
[journal]
Ahmed MI
/ 2005
/ Harpagophytum procumbens(Devil’s Claw) : a possible natural anti-inflammatory agent(an experimental study)
/ Iran J Pharmacol Ther
4
: 54~63
[journal]
Altman, RD
/ 2009
/ Glucosamine therapy for knee osteoarthritis : pharmacokinetic considerations
/ Expert Rev Clin Pharmacol
2
: 359~371
[journal]
Altman RD
/ 2001
/ Effects of a ginger extract on knee pain in patients with osteoarthritis
/ Arthritis Rheum
44
: 2531~2538
[journal]
Anderson J
/ 2005
/ Glucosamine effects in humans : a review of effects on glucose metabolism, side effects, safety considerations and efficacy
/ Food Chem Toxicol
43
: 187~201
[journal]
Barcelo HA
/ 1987
/ Effect of S-adenosylmethionine on experimental osteoarthritis in rabbits
/ Am J Med
83
: 55~59
[journal]
Barclay TS
/ 1998
/ Glucosamine
/ Ann Pharmacother
32
: 574~579
[journal]
Barthe L
/ 2004
/ In vitro intestinal degradation and absorption of chondroitin sulfate, a glycosaminoglycan drug
/ Arzneimittel forschung
54
: 286~292
[journal]
Bassleer CT
/ 1998
/ Effects of chondroitin sulfate and interleukin-1 beta on human articular chondrocytes cultivated in clusters
/ Osteoarthritis Cartilage
6
: 196~204
[journal]
Bliddal H
/ 2000
/ A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis
/ Osteoarthritis Cartilage
8
: 9~12
[journal]
Brien S
/ 2006
/ Devil’s Claw(Harpagophytum procumbens)as a treatment for osteoarthritis : a review of efficacy and safety
/ J Altern Complement Med
12
: 981~993
[journal]
Bruyère O
/ 2014
/ An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally : a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO)
/ Semin Arthritis Rheum
44
: 253~263
[journal]
Bruyere O
/ 2004
/ Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis : evidence from two 3-year studies
/ Menopause
11
: 138~143
[journal]
Bucsi L
/ 1998
/ Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis(SYSADOA)in the treatment of knee osteoarthritis
/ Osteoarthritis Cartilage
6
: 31~36
[journal]
Calamia V
/ 2010
/ Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
/ Arthritis Res Ther
12
: R138~
[journal]
Cameron M
/ 2013
/ Topical herbal therapies for treating osteoarthritis
/ Cochrane Database Syst Rev
5
: CD010538~
[journal]
Cameron M
/ 2009
/ Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 1: osteoarthritis
/ Phytother Res
23
: 1497~1515
[journal]
Catelan SC
/ 2006
/ The role of adrenalcorticosteroids in the anti-inflammatory effect of the whole extract of Harpagophytum procumbens in rats
/ Phytomedicine
13
: 446~451
[journal]
Caterina MJ
/ 1997
/ The capsaicin receptor : a heat activated ion channel in the pain pathway
/ Nature
389
: 816~824
[journal]
Cheleschi S
/ 2015
/ Chondroprotective effect of three different classes of antiinflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β
/ Int Immunopharmacol
28
: 794~801
[journal]
Cho JW
/ 2007
/ Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNFalpha-treated HaCaT cells; NFkappaB and MAPKs as potential upstream targets
/ Int J Mol Med
19
: 469~474
[journal]
Clarkson C
/ 2006
/ Identification of major and minor constituents of Harpagophytum procumbens using HPLC-SPE-NMR and HPLC/ESIMS/APCIMS
/ J Nat Prod
69
: 1280~1288
[journal]
Conrozier T
/ 2014
/ A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain
/ Altern Ther Health Med
20
: 32~37
[journal]
de Silva V
/ 2011
/ Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis : a systematic review
/ Rheumatol
50
: 911~920
[journal]
Deal CL
/ 1999
/ Nutraceuticals as therapeutic agents in osteoarthritis : the role of glucosamine, chondroitin sulfate, and collagen hydrolysate
/ Rheum Dis Clin North Am
25
: 379~395
[journal]
Deodhar SD
/ 1980
/ Preliminary study on antirheumatic activity of curcumin(diferuloyl methane)
/ Indian J Med Res
71
: 632~634
[journal]
Ezaki J
/ 2013
/ Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model
/ J Bone Miner Metab
31
: 16~25
[journal]
Fiebich BL
/ 2001
/ Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69
/ Phytomedicine
8
: 28~30
[journal]
Fransen M
/ 2015
/ Glucosamine and chondroitin for knee osteoarthritis : a double-blind randomised placebocontrolled clinical trial evaluating single and combination regimens
/ Ann Rheum Dis
74
: 851~858
[journal]
Fransen M
/ 2011
/ The epidemiology of osteoarthritis in Asia
/ Int J Rheum Dis
14
: 113~121
[journal]
Frondoza CG
/ 2004
/ An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures
/ In Vitro Cell Dev Biol Anim
40
: 95~101
[journal]
Gagnier JJ
/ 2007
/ Herbal medicine for low back pain : a Cochrane review
/ Spine
32
: 82~92
[journal]
Gregory PJ
/ 2008
/ Dietary supplements for osteoarthritis
/ Am Fam Phys
77
: 177~184
[journal]
Carmelita G. Frondoza
/ 2005
/
Ginger-An Herbal Medicinal Product with Broad Anti-Inflammatory Actions
/ Journal of Medicinal Food
/ 한국식품영양과학회
8(2)
: 125~132
[journal]
Herrero-Beaumont G
/ 2007
/ Glucosamine sulfate in the treatment of knee osteoarthritis symptoms : a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator
/ Arthritis Rheum
56
: 555~567
[journal]
Houpt JB
/ 1999
/ Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee
/ J Rheumatol
26
: 2423~2430
[journal]
Huang G
/ 2013
/ Curcumin protects against collagen-induced arthritis via suppression of BAFF production
/ J Clin Immunol
33
: 550~557
[journal]
Huskisson E
/ 2008
/ Glucosamine and chondroitin for osteoarthritis
/ J Int Med Res
36
: 1161~1179
[journal]
Shaikh Imtiyaz
/ 2013
/
Zingiber officinale Rosc.: A traditional herb with medicinal properties
/ TANG [HUMANITAS MEDICINE]
/ 후마니타스의학회
3(4)
: 26~26
[journal]
Jackson CG
/ 2010
/ The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination
/ Osteoarthritis Cartilage
18
: 297~302
[journal]
Jang MH
/ 2003
/ Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929
/ J Pharm Sci
93
: 367~371
[journal]
Jin CY
/ 2007
/ Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia
/ Acta Pharmacol Sin
28
: 1645~1651
[journal]
Joe B
/ 1997
/ Presence of an acidic glycoprotein in the serum of arthritic rats : modulation by capsaicin and curcumin
/ Mol Cell Biochem
169
: 125~134
[journal]
Kahan A
/ 2009
/ Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis
/ Arthritis Rheum
60
: 524~533
[journal]
Kim CS
/ 2003
/ Capsaicin exhibits anti-inflammatory property by inhibiting IkB-α degradation in LPS-stimulated peritoneal macrophages
/ Cell Signal
15
: 299~306
[journal]
Kim JH
/ 2012
/ Turme ric(Curcuma longa)inhibits inflammatory nuclear factor(NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis
/ Mol Nutr Food Res
56
: 454~465
[journal]
Kim LS
/ 2006
/ Efficacy of methylsulfonylmethane(MSM)in osteoarthritis pain of the knee : a pilot clinical trial
/ Osteoarthritis Cartilage
14
: 286~294
[journal]
Knotkova H
/ 2008
/ Capsaicin (TRPV1agonist) therapy for pain relief: farewell or revival?
/ Clin J Pain
24
: 142~154
[journal]
Kiuchi F
/ 1992
/ Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids
/ Chem Pharm Bull
40
: 387~391
[journal]
Kopsidas G
/ 1994
/ Mutagenesis by 9-aminoacridine in Salmonella typhimurium : inhibition by glucose and other PTS class A carbon sources
/ Mutat Res
306
: 111~117
[journal]
Vikas Kumar
/ 2015
/
Potential of some traditionally used edible plants for prevention and cure of diabesity associated comorbidities
/ TANG [HUMANITAS MEDICINE]
/ 후마니타스의학회
5(2)
: 8~8
[journal]
Kundu JK
/ 2005
/ Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R.Br. and Harpagophytum procumbens DC. On phorbolester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets
/ Cancer Lett
218
: 21~31
[journal]
Lamari FN
/ 2006
/ Metabolism and biochemical/physiological roles of chondroitin sulfates : analysis of endogenous and supplemental chondroitin sulfates in blood circulation
/ Biomed Chromatogr
20
: 539~550
[journal]
Largo R
/ 2003
/ Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes
/ Osteoarthritis Cartilage
11
: 290~298
[journal]
Laslett LL
/ 2014
/ Capsaicin for osteoarthritis pain
/ Prog Drug Res
68
: 277~291
[journal]
Lippiello L
/ 2000
/ In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate
/ Clin Orthop Relat Res
381
: 229~240
[journal]
Maccagno A
/ 1987
/ Doubleblind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis
/ Am J Med
83
: 72~77
[journal]
Mazières B
/ 2007
/ Effect of chondroitin sulphate in symptomatic knee osteoarthritis : a multicentre, randomised, double-blind, placebo-controlled study
/ Ann Rheum Dis
66
: 639~645
[journal]
Mncwangi N
/ 2012
/ Devil’s claw – a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
/ J. Ethnopharmacol
143
: 755~771
[journal]
Monfort J
/ 2005
/ Chondroitin sulfate and hyaluronic acid(500-730 kDa)inhibit stromelysin-1 synthesis in human osteoarthritic chondrocytes
/ Drugs Exp Clin Res
31
: 71~76
[journal]
Morelli V
/ 2003
/ Alternative therapies for traditional disease states : osteoarthritis
/ Am Fam Phys
67
: 339~344
[journal]
Na HK
/ 2004
/ Inhibition of phorbolester-induced COX-2 expression by some edible African plants
/ Biofactors
21
: 149~153
[journal]
Najm WI
/ 2004
/ Sadenosyl methionine(SAMe)versus celecoxib for the treatment of osteoarthritis symptoms : a double-blind cross-over trial
/ BMC Musculoskelet Disord
5
: 6~
[journal]
Notoya K
/ 2000
/ The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2
/ J Immunol
165
: 3402~3410
[journal]
O’Neill J
/ 2012
/ Unravelling the mystery of capsaicin : a tool to understand and treat pain
/ Pharmacol Rev
64
: 939~971
[journal]
Okazaki J
/ 1995
/ Disaccharide analysis of chondroitin sulphate in human gingival crevicular fluid using high-performance liquid chromatography
/ Arch Oral Biol
40
: 777~779
[journal]
Owens S
/ 2004
/ Recent advances in glucosamine and chondroitin supplementation
/ J Knee Surg
17
: 185~193
[journal]
Park C
/ 2007
/ Curcumin induces apoptosis and inhibits prostaglandin E(2)production in synovial fibroblasts of patients with rheumatoid arthritis
/ Int J Mol Med
20
: 365~372
[journal]
Park JS
/ 2000
/ Capsaicin protects against ethanol-induced oxidative injury in the gastricmucosa of rats
/ Life Sci
67
: 3087~3093
[journal]
Park SY
/ 2012
/ Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2through inhibition of NF-κB activation in TPA-induced breast cancer cells
/ J Cell Biochem
113
: 3653~3662
[journal]
Pavelka K
/ 2002
/ Glucosamine sulphate use and delay of progression of knee osteoarthritis : a 3-year, randomized, placebo-controlled, double-blind study
/ Arch Intern Med
162
: 2113~2123
[journal]
Pouwels MJ
/ 2001
/ Short-term glucosamine infusion does not affect insulin sensitivity in humans
/ J Clin Endocrinol Metab
86
: 2099~2103
[journal]
Rainsford KD
/ 1999
/ Profile and mechanisms of gastrointestinal and other side effects of nonsteroidal anti-inflammatory drugs(NSAIDs)
/ Am J Med
107
: 27~35
[journal]
Reginster JY
/ 2001
/ Long-term effects of glucosamine sulphate on osteoarthritis progression : a randomised, placebo-controlled clinical trial
/ Lancet
357
: 251~256
[journal]
Ronca G
/ 1993
/ Metabolic fate of partially depolymerized shark chondroitin sulfate in man
/ Int J Clin Pharmacol Res
13
: 27~34
[journal]
Rovati LC
/ 1999
/ Glucosamine in osteoarthritis
/ Lancet
354
: 1640~1642
[journal]
Rovetta G
/ 2002
/ Chondroitin sulfate in erosive osteoarthritis of the hands
/ Int J Tissue React
24
: 29~32
[journal]
Schulze-Tanzil G
/ 2004
/ Effect of a Harpagophytum procumbens DC extract on matric metalloproteinases in human chondrocytes in vitro
/ Arzneimittelforschung
54
: 213~220
[journal]
Setnikar I
/ 2001
/ Absorption, distribution, metabolism and excretion of glucosamine sulfate
/ Arzneimittel forschung
51
: 699~725
[journal]
Stewart KM
/ 2005
/ The commercial harvest of Devil’s Claw (Harpagophytum spp.) in southern Africa: the devil’s in the details
/ J Ethnopharmacol
100
: 225~236
[journal]
Szallasi A
/ 1999
/ Vanilloid(capsaicin)receptors and mechanisms
/ Pharmacol Rev
51
: 159~212
[journal]
Towheed TE
/ 2009
/ Glucosamine therapy for treating osteoarthritis
/ Cochrane Database Syst Rev
: CD002946~
[journal]
Uebelhart D
/ 2004
/ Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate : a one-year, randomized, double-blind, multicenter study versus placebo
/ Osteoarthritis Cartilage
12
: 269~276
[journal]
Usha PR
/ 2004
/ Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis
/ Clin Drug Investig
24
: 353~363
[journal]
van Wyk BE
/ 2008
/ A broad review of commercially important southern African medicinal plants
/ J Ethnopharmacol
119
: 342~355
[journal]
Vetter G
/ 1969
/ Topical therapy of arthroses with glucosamines(Dona 200)
/ Munch Med Wochenschr
111
: 1499~1502
[journal]
Wolfe MM
/ 1999
/ Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
/ New Engl J Med
340
: 1888~1899