CELLMED 2023 KCI Impact Factor : 0.03
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pISSN : 3022-6805 / eISSN : 3022-6791
- https://journal.kci.go.kr/cellmed
KJCKorea
Journal Central
The role of thymic stromal lymphopoietin on mast cell-mediated allergic inflammatory reactions
- CELLMED
- Abbr : CellMed
- 2016, 6(3), pp.16-16
- Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
- Research Area : Medicine and Pharmacy > General Medicine
1우석대학교
Candidate
ABSTRACT
Thymic stromal lymphopoietin (TSLP) is a novel interleukin (IL)-7-like cytokine and was originally discovered in the supernatant of a murine thymic stromal cell line. TSLP signal initiates via complex of the TSLP receptor and the IL-7 receptor α chain. TSLP expression is closely connected with many diseases such as atopic dermatitis, allergic rhinitis, asthma, inflammatory arthritis, eosinophilic esophagitis, rheumatoid arthritis, inflammatory bowel diseases, and cancer. In this review, I discussed biological roles of TSLP on mast cell-mediated allergic responses. In addition, this review summarizes the effective drugs in allergic-inflammatory reactions induced by TSLP on mast cells.
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