@article{ART002164254},
author={Hyun-Ja Jeong and 남선영 and 이병주 and 김민기 and 김정화 and Hyung-Min Kim},
title={An alternative method to reduce anaphylaxis by moxibustion},
journal={CELLMED},
issn={3022-6805},
year={2014},
volume={4},
number={2},
pages={12-12},
doi={10.5667/tang.2014.0011}
TY - JOUR
AU - Hyun-Ja Jeong
AU - 남선영
AU - 이병주
AU - 김민기
AU - 김정화
AU - Hyung-Min Kim
TI - An alternative method to reduce anaphylaxis by moxibustion
JO - CELLMED
PY - 2014
VL - 4
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 12
EP - 12
SN - 3022-6805
AB - Epinephrine is a critical drug for patients at risk for anaphylaxis. Here, we suggest moxibustion as an alternative method to reduce anaphylaxis. Moxibustion was applied to the Shimen (CV5) acupoint and found to attenuate compound 48/80-induced mortality. Capsazepine, a transient receptor potential vanilloid (TRPV) 1 antagonist, significantly improved overall survival rates compared to groups treated with moxibustion or 2-aminoethoxydiphenyl borate (an activator of TRPV1, 2, and 3). Probenecid (a TRPV2 agonist) also increased survival rate and reduced histamine levels. Survival rates increased by moxibustion and probenecid were completely inhibited by ruthenium red (a TRPV2 and 3 antagonist) and gadolinium chloride (general TRPV antagonist), respectively. Passive cutaneous anaphylaxis and ear swelling were significantly reduced by moxibustion and probenecid ( p < 0.05). In cardiomyocytes, TRPV2 was over-expressed by compound 48/80 and histamine but this increased TRPV2 expression decreased to baseline with moxibustion and probenecid treatment. In addition, intracellular calcium levels increased by compound 48/80 were reduced by probenecid. Overall, these findings suggest that the reduction of anaphylaxis caused by moxibustion could represent a new mechanism of moxibustion related to the regulation of TRPV2 activation and promotion of epinephrine secretion.
KW - anaphylaxis;moxibustion;transient receptor potential vanilloid2;epinephrine
DO - 10.5667/tang.2014.0011
ER -
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화 and Hyung-Min Kim. (2014). An alternative method to reduce anaphylaxis by moxibustion. CELLMED, 4(2), 12-12.
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화 and Hyung-Min Kim. 2014, "An alternative method to reduce anaphylaxis by moxibustion", CELLMED, vol.4, no.2 pp.12-12. Available from: doi:10.5667/tang.2014.0011
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화, Hyung-Min Kim "An alternative method to reduce anaphylaxis by moxibustion" CELLMED 4.2 pp.12-12 (2014) : 12.
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화, Hyung-Min Kim. An alternative method to reduce anaphylaxis by moxibustion. 2014; 4(2), 12-12. Available from: doi:10.5667/tang.2014.0011
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화 and Hyung-Min Kim. "An alternative method to reduce anaphylaxis by moxibustion" CELLMED 4, no.2 (2014) : 12-12.doi: 10.5667/tang.2014.0011
Hyun-Ja Jeong; 남선영; 이병주; 김민기; 김정화; Hyung-Min Kim. An alternative method to reduce anaphylaxis by moxibustion. CELLMED, 4(2), 12-12. doi: 10.5667/tang.2014.0011
Hyun-Ja Jeong; 남선영; 이병주; 김민기; 김정화; Hyung-Min Kim. An alternative method to reduce anaphylaxis by moxibustion. CELLMED. 2014; 4(2) 12-12. doi: 10.5667/tang.2014.0011
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화, Hyung-Min Kim. An alternative method to reduce anaphylaxis by moxibustion. 2014; 4(2), 12-12. Available from: doi:10.5667/tang.2014.0011
Hyun-Ja Jeong, 남선영, 이병주, 김민기, 김정화 and Hyung-Min Kim. "An alternative method to reduce anaphylaxis by moxibustion" CELLMED 4, no.2 (2014) : 12-12.doi: 10.5667/tang.2014.0011
