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@article{ART002164273},
author={Chin Eng Ong and Yan Pan},
title={Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs},
journal={CELLMED},
issn={3022-6805},
year={2014},
volume={4},
number={3},
pages={17-17},
doi={10.5667/tang.2014.0008}

TY - JOUR
AU - Chin Eng Ong
AU - Yan Pan
TI - Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs
JO - CELLMED
PY - 2014
VL - 4
IS - 3
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 17
EP - 17
SN - 3022-6805
AB - Herbal remedies are commonly used by patients worldwide. Because these herbal preparations share the same metabolic and transport proteins with prescribed medicines, the potential for a drug-herb interaction is substantial and is an issue of significant concern. This review paper summarizes drug-herb interactions involving inhibition or induction of cytochrome P450 enzymes, drug transporters as well as modulation of drug pharmacodynamics. An increasing number of in vitro and animal studies, case reports and clinical trials evaluating such interactions have been reported, and implications of these studies are discussed in this review. The most commonly implicated drugs in the interaction include anticoagulants, antiplatelets, immunosuppressants, anti-neoplastics, protease inhibitors, and some antidepressants. Pharmacokinetic and/or pharmacodynamic interactions of five commonly used herbal remedies (danshen, garlic, Ginkgo biloba, ginseng, and St John’s wort) with these drugs are presented, with focus of discussion being the potentials for interaction, their mechanisms and clinical implications. There is a necessity for adequate pharmacovigilance to be carried out in minimizing unanticipated but often preventable drug-herb interactions.
KW - cytochrome P450;drug-herb interaction;P-glycoprotein;pharmacodynamics;pharmacokinetics
DO - 10.5667/tang.2014.0008
ER -

Chin Eng Ong and Yan Pan. (2014). Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs. CELLMED, 4(3), 17-17.

Chin Eng Ong and Yan Pan. 2014, "Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs", CELLMED, vol.4, no.3 pp.17-17. Available from: doi:10.5667/tang.2014.0008

Chin Eng Ong, Yan Pan "Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs" CELLMED 4.3 pp.17-17 (2014) : 17.

Chin Eng Ong, Yan Pan. Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs. 2014; 4(3), 17-17. Available from: doi:10.5667/tang.2014.0008

Chin Eng Ong and Yan Pan. "Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs" CELLMED 4, no.3 (2014) : 17-17.doi: 10.5667/tang.2014.0008

Chin Eng Ong; Yan Pan. Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs. CELLMED, 4(3), 17-17. doi: 10.5667/tang.2014.0008

Chin Eng Ong; Yan Pan. Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs. CELLMED. 2014; 4(3) 17-17. doi: 10.5667/tang.2014.0008

Chin Eng Ong, Yan Pan. Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs. 2014; 4(3), 17-17. Available from: doi:10.5667/tang.2014.0008

Chin Eng Ong and Yan Pan. "Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs" CELLMED 4, no.3 (2014) : 17-17.doi: 10.5667/tang.2014.0008