Potential mechanism of anti-diabetic activity of Picrorhiza kurroa

Gulam Mohammed Husain; Richa Rai; Geeta Rai; Harikesh Bahadur Singh; Ajit Kumar Thakur; Vikas Kumar

Potential mechanism of anti-diabetic activity of Picrorhiza kurroa

CELLMED
Abbr : CellMed
2014, 4(4), pp.27-27
Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
Research Area : Medicine and Pharmacy > General Medicine

Gulam Mohammed Husain ¹, Richa Rai ², Geeta Rai ², Harikesh Bahadur Singh ², Ajit Kumar Thakur ¹, Vikas Kumar ²

¹Indian Institute of Technology
²Banaras Hindu University

ABSTRACT

Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) is a traditional Ayurvedic herb known as Kutki. It is used as a remedy for diabetes by tribes of North Eastern Himalayan region of India. Present study was conducted to explore the mechanism of antidiabetic activity of standardized aqueous extract of Picrorhiza kurroa (PkE). PkE (100 and 200 mg/kg/day) was orally administered to streptozotocin induced diabetic rats, for 14 consecutive days. Plasma insulin levels were measured and pancreas of rat was subjected to histopathological investigations. Glucose transporter type 4 (GLUT-4) protein content in the total membrane fractions of soleus muscle was estimated by Western blot analysis. Plasma insulin level was significantly increased along with concomitant increase in GLUT-4 content of total membrane fractions of soleus muscle of diabetic rats treated with extract. There was evidence of regeneration of β-cells of pancreatic islets of PkE treated group in histopathological examinations. PkE increased the insulin-mediated translocation of GLUT-4 from cytosol to plasma membrane or increased GLUT-4 expression, which in turn facilitated glucose uptake by skeletal muscles in diabetic rats.

KEYWORDS

Picrorhiza kurroa, type 2 diabetes, GLUT-4, pancreas, histopathology

Citation status

* References for papers published after 2023 are currently being built.

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