@article{ART002175792},
author={Auro del Giglio and Ary Serpa and Daniel Cubero and Rachel Riechelman and Maira Paschoin },
title={Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials},
journal={CELLMED},
issn={3022-6805},
year={2011},
volume={1},
number={1},
pages={6-6}
TY - JOUR
AU - Auro del Giglio
AU - Ary Serpa
AU - Daniel Cubero
AU - Rachel Riechelman
AU - Maira Paschoin
TI - Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials
JO - CELLMED
PY - 2011
VL - 1
IS - 1
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 6
EP - 6
SN - 3022-6805
AB - For cancer patients undergoing radiation therapy (RT) or systemic chemotherapy (CHT), cancer-related fatigue (CRF) is a common problem that can negatively impact their quality of life. Guarana (Paullinia cupana) is a plant native to the Amazon basin that has been used as a stimulant since pre-Columbian times. PURPOSE: To evaluate the effectiveness of guarana extract on fatigue in BC patients undergoing either CHT or RT. A total of 137 cancer patients (85% with Breast Cancer) undergoing either CHT (101) or RT (36) were randomized to receive either a placebo or guarana. In all 3 studies, the guarana was given as an unmanipulated dry extract at a dose of 75 mg PO QD in the first two studies or 50 mg PO BID in the third study. Patients were crossed over to the other experimental arm, and we evaluated fatigue with the Chalder Scale in all three studies. Guarana significantly improved the The Chalder Scale Global Scores (- 0.85; 95% CI:-1.31 to - 0.40; p = 0.0002); Physical Fatigue Scores (- 0.44; 95% CI: - 0.74 to -0.13; p = 0.005) and Mental Fatigue Scores (- 0.93; 95% CI: - 1.14 to - 0.72; p < 0.00001). Guarana did not produce any CTCAE grades 3 or 4 toxicities in any of the studies. Guarana is an effective, cheap and non-toxic alternative for the treatment of fatigue in cancer patients undergoing treatment.
KW - Paulinia cupana;radiation therapy;chemotherapy
DO -
UR -
ER -
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman and Maira Paschoin . (2011). Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials. CELLMED, 1(1), 6-6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman and Maira Paschoin . 2011, "Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials", CELLMED, vol.1, no.1 pp.6-6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman, Maira Paschoin "Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials" CELLMED 1.1 pp.6-6 (2011) : 6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman, Maira Paschoin . Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials. 2011; 1(1), 6-6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman and Maira Paschoin . "Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials" CELLMED 1, no.1 (2011) : 6-6.
Auro del Giglio; Ary Serpa; Daniel Cubero; Rachel Riechelman; Maira Paschoin . Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials. CELLMED, 1(1), 6-6.
Auro del Giglio; Ary Serpa; Daniel Cubero; Rachel Riechelman; Maira Paschoin . Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials. CELLMED. 2011; 1(1) 6-6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman, Maira Paschoin . Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials. 2011; 1(1), 6-6.
Auro del Giglio, Ary Serpa, Daniel Cubero, Rachel Riechelman and Maira Paschoin . "Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials" CELLMED 1, no.1 (2011) : 6-6.
