@article{ART002175829},
author={Amrendra Kumar Chaudhary and Ruchi Solanki and Vandana Singh and Umesh Kumar Singh},
title={Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia},
journal={CELLMED},
issn={3022-6805},
year={2012},
volume={2},
number={2},
pages={19-19}
TY - JOUR
AU - Amrendra Kumar Chaudhary
AU - Ruchi Solanki
AU - Vandana Singh
AU - Umesh Kumar Singh
TI - Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia
JO - CELLMED
PY - 2012
VL - 2
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 19
EP - 19
SN - 3022-6805
AB - Capparis zeylanica Linn. a ‘Rasayana’ drug is used for its memory enhancing effects in the traditional Ayurvedic system of medicine. The aim of this study was to evaluate acetylcholinesterase (AChE) inhibitory and memory enhancing activities of Capparis zeylanica Linn. The in-vitro and ex-vivo models of AChE inhibitory activity were used along with Morris water maze test to study the effect on memory in rats. The anticholinesterase effect of methanolic and aqueous extracts of Capparis zeylanica was measured by spectrophotometric Ellman method at 0.1, 0.3, 1.0, 3.0, 10 and 30 mg/ml and brain monoamine oxidase (MAO-A and MAO-B) activity was assessed by Naoi’s method. The results of in-vivo and ex-vivo AChE assay revealed that methanolic and aqueous extracts of Capparis zeylanica inhibit AChE activity, whereas these extracts did not alter MAO activity at any concentration tested as compared to moclobemide and L-deprenyl. The results indicate that Capparis zeylanica improves scopolamine-induced memory deficits through inhibition of AChE activity, and not by direct MAO inhibition.
KW - Capparis zeylanica Linn;Rasayana drug;anticholinesterase;MAO activity;amnesia;scopolamine
DO -
UR -
ER -
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh and Umesh Kumar Singh. (2012). Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia. CELLMED, 2(2), 19-19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh and Umesh Kumar Singh. 2012, "Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia", CELLMED, vol.2, no.2 pp.19-19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh, Umesh Kumar Singh "Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia" CELLMED 2.2 pp.19-19 (2012) : 19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh, Umesh Kumar Singh. Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia. 2012; 2(2), 19-19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh and Umesh Kumar Singh. "Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia" CELLMED 2, no.2 (2012) : 19-19.
Amrendra Kumar Chaudhary; Ruchi Solanki; Vandana Singh; Umesh Kumar Singh. Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia. CELLMED, 2(2), 19-19.
Amrendra Kumar Chaudhary; Ruchi Solanki; Vandana Singh; Umesh Kumar Singh. Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia. CELLMED. 2012; 2(2) 19-19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh, Umesh Kumar Singh. Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia. 2012; 2(2), 19-19.
Amrendra Kumar Chaudhary, Ruchi Solanki, Vandana Singh and Umesh Kumar Singh. "Inhibitory effect of Capparis zeylanica Linn. on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia" CELLMED 2, no.2 (2012) : 19-19.
