Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

송영훈; 남선영; Youngjin Choi (최영진); Jung Hwa Kim (김정화); KIM YOUNGSIK (김영식); Hyun-Ja Jeong (정현자)

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

CELLMED
Abbr : CellMed
2012, 2(3), pp.29-29
Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
Research Area : Medicine and Pharmacy > General Medicine

송영훈 ¹, 남선영 ¹, Youngjin Choi ², Jung Hwa Kim ³, KIM YOUNGSIK ¹, Hyun-Ja Jeong ²

¹경희대학교
²호서대학교
³이화여자대학교

ABSTRACT

The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

KEYWORDS

caspase-1, hesperidin, molecular docking simulation, Pyeongwee-San (KMP6), thymic stromal lymphopoietin

Citation status

* References for papers published after 2023 are currently being built.

[journal] Allakhverdi Z / 2007 / Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells / J Exp Med 204 : 253~258

[journal] Arafa HM / 2009 / Hesperidin attenuates benzo [alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance / Toxicol Ind Health 25 : 417~427

[journal] Asher MI / 2006 / Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood : ISAAC Phases One and Three repeat multicountry cross-sectional surveys / Lancet 368 : 733~743

[journal] Bailey WC / 1992 / Asthma prevention. Task force on research and education for the prevention and control of respiratory diseases / Chest 102 : 216S~231S

[journal] Benavente-Garcia O / 2008 / Update on uses and properties of citrus flavonoids : new findings in anticancer, cardiovascular, and anti-inflammatory activity / J Agric Food Chem 56 : 6185~6205

[journal] Bunyavanich S / 2011 / Thymic stromal lymphopoietin(TSLP)is associated with allergic rhinitis in children with asthma / Clin Mol Allergy 9 : 1~

[journal] Butterfield JH / 1988 / Establishment of an immature mast cell line from a patient with mast cell leukemia / Leuk Res 12 : 345~355

[journal] Camargo CA Jr / 2009 / Managing asthma exacerbations in the emergency department: summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines for the management of asthma exacerbations / J Emerg Med 37 : S6~S17

[journal] Choi IY / 2007 / Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells / Mol Cell Biochem 305 : 153~161

[journal] Faubel S / 2007 / Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin(IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney / J Pharmacol Exp Ther 322 : 8~15

[journal] Ford, ME / 1996 / An empowerment-centered, church-based asthma education program for African American adults / Health and Social Work 21 : 70~75

[journal] Galli SJ / 2008 / Immunomodulatory mast cells : negative, as well as positive, regulators of immunity / Nat Rev Immunol 8 : 478~486

[journal] Han NR / 2012 / Effect of Pyeongwee-San(KMP6)on 2, 4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice / Life Sci 90 : 147~153

[journal] Han NR / 2011 / Kanamycin activates caspase-1 in NC/Nga mice / Exp Dermatol 20 : 659~663

[journal] Hansel NN / 2011 / Predicting future asthma morbidity in preschool inner-city children / J Asthma 48 : 797~803

[journal] Jeong HJ / 2011 / C-Kit Binding Properties of Hesperidin (a Major Component of KMP6) as a Potential Anti-Allergic Agent / PLoS One 6 : e19528~

[journal] Kang TH / 2011 / Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III / J Nat Prod 74 : 223~227

[journal] Kitajima J / 2003 / Glycosides of Atractylodes lancea / Chem Pharm Bull 51 : 673~678

[journal] Kimura I / 2006 / Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions / Yakugaku Zasshi 126 : 133~143

[journal] Kobayashi K / 2002 / RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems / Nature 416 : 194~199

[journal] Kuida K / 1995 / Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme / Science 267 : 2000~2003

[journal] Leonard WJ / 2002 / TSLP : Finally in the limelight / Nat Immunol 3 : 605~607

[journal] Leung DY / 2000 / Atopic dermatitis : new insights and opportunities for therapeutic intervention / J Allergy Clin Immunol 105 : 860~876

[journal] Liu YJ / 2006 / Thymic stromal lymphopoietin : Master switch for allergic inflammation / J Exp Med 203 : 269~273

[journal] Miller GE / 2001 / Psychological interventions and the immune system : A meta-analytic review and critique / Health Psychology 20 : 47~63

[journal] Miyata M / 2008 / Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis / Eur J Immunol 38 : 1487~1492

[journal] Miyazaki D / 2005 / Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions / J Clin Invest 115 : 434~442

[journal] Moon PD / 2011 / Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells / Cytokine 54 : 239~243

[journal] Oh HA / 2012 / Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract(KMP6) / Immunopharmacol Immunotoxicol 34 : 135~142

[journal] 정현자 / 2012 / Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model / TANG [HUMANITAS MEDICINE] / 후마니타스 세포교정의학회 2(1) : 9~9

[journal] Parker-Oliver D / 2005 / Asthma management : A role for social work / Health and Social work 30 : 167~170

[journal] Rahman S / 2007 / Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in Swiss albino mice / J Enzyme Inhib Med Chem 22 : 363~369

[journal] Reed SD / 2004 / The economic burden of allergic rhinitis / Pharmacoeconomics 22 : 345~361

[journal] Sakurai T / 1993 / Enzyme inhibitory activities of acetylene and sesquiterpene compounds in atractylodes rhizome / Biolo Pharm Bull 16 : 142~145

[journal] Takei M / 2006 / Glycyrrhizin inhibits the manifestations of anti-inflammatory responses that appear in association with systemic inflammatory response syndrome(SIRS)-like reactions / Cytokine 35 : 295~301

[journal] Tanaka K / 2007 / Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappa B / Eur J Pharmacol 565 : 212~219

[journal] Taylor BC / 2009 / TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis / J Exp Med 206 : 655~667

[journal] Wu X / 2009 / TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism / Am J Physiol Renal Physiol 297 : F316~F326

[journal] Yao TC / 2011 / Associations of age, gender, and BMI with prevalence of allergic diseases in children : PATCH study / J Asthma 48 : 503~510

[journal] Zhang K / 2007 / Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease / Am J Physiol Lung Cell Mol Physiol 293 : L375~L382

[journal] Ziegler SF / 2010 / Sensing the outside world : TSLP regulates barrier immunity / Nat Immunol 11 : 289~293

KJCKorea
Journal Central

CELLMED 2023 KCI Impact Factor : 0.02