@article{ART002175873},
author={Syafawati Shamsahal Din and Siti Syariah Mamat and Noor Aisyah Ismail and Wan Noraziemah Wan Zainulddin and Zalina Zabidi and Farhana Yahya and Farah Hidayah Kamisan and Norhafizah Mohtarrudin and Fezah Othman and Zarizal Suhaili and Zainul Amiruddin Zakaria},
title={Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats},
journal={CELLMED},
issn={3022-6805},
year={2012},
volume={2},
number={4},
pages={34-34}
TY - JOUR
AU - Syafawati Shamsahal Din
AU - Siti Syariah Mamat
AU - Noor Aisyah Ismail
AU - Wan Noraziemah Wan Zainulddin
AU - Zalina Zabidi
AU - Farhana Yahya
AU - Farah Hidayah Kamisan
AU - Norhafizah Mohtarrudin
AU - Fezah Othman
AU - Zarizal Suhaili
AU - Zainul Amiruddin Zakaria
TI - Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats
JO - CELLMED
PY - 2012
VL - 2
IS - 4
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 34
EP - 34
SN - 3022-6805
AB - The present study aimed to determine the hepatoprotective activity of the chloroform extract of D. linearis leaves (CEDL) using the paracetamol (PCM)- and carbon tetrachloride (CCl4)-induced liver injury models in rats. The rats received dH2O (negative control), 200 mg/kg of silymarin (positive control) or CEDL (50, 250 and 500 mg/kg) orally once daily for 7 days and then were subjected to the hepatotoxic induction on the 7th day. The samples (i.e. blood and liver) were collected and underwent biochemical and microscopical analysis, respectively. From the data obtained, both inducers caused significant (p < 0.05) increase in the levels of AST and ALT when compared to the control group, which were significantly (p < 0.05) reduced by CEDL in a generally dose-dependent manner. These biochemical findings were supported by the histopathological analysis and histological scoring. In conclusion, CEDL possesses potential hepatoprotective activity, which could be associated with its flavonoid and tannin contents with the mechanisms of hepatoprotection linked to either its antioxidant or anti-inflammtory /immunomodulating activities. Further in-depth studies are required to identify the responsible bioactive compound.
KW - Dicranopteris linearis;Gleicheniaceae;in vivo;hepatoprotective activity;chloroform extract;leaves
DO -
UR -
ER -
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili and Zainul Amiruddin Zakaria. (2012). Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats. CELLMED, 2(4), 34-34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili and Zainul Amiruddin Zakaria. 2012, "Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats", CELLMED, vol.2, no.4 pp.34-34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili, Zainul Amiruddin Zakaria "Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats" CELLMED 2.4 pp.34-34 (2012) : 34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili, Zainul Amiruddin Zakaria. Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats. 2012; 2(4), 34-34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili and Zainul Amiruddin Zakaria. "Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats" CELLMED 2, no.4 (2012) : 34-34.
Syafawati Shamsahal Din; Siti Syariah Mamat; Noor Aisyah Ismail; Wan Noraziemah Wan Zainulddin; Zalina Zabidi; Farhana Yahya; Farah Hidayah Kamisan; Norhafizah Mohtarrudin; Fezah Othman; Zarizal Suhaili; Zainul Amiruddin Zakaria. Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats. CELLMED, 2(4), 34-34.
Syafawati Shamsahal Din; Siti Syariah Mamat; Noor Aisyah Ismail; Wan Noraziemah Wan Zainulddin; Zalina Zabidi; Farhana Yahya; Farah Hidayah Kamisan; Norhafizah Mohtarrudin; Fezah Othman; Zarizal Suhaili; Zainul Amiruddin Zakaria. Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats. CELLMED. 2012; 2(4) 34-34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili, Zainul Amiruddin Zakaria. Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats. 2012; 2(4), 34-34.
Syafawati Shamsahal Din, Siti Syariah Mamat, Noor Aisyah Ismail, Wan Noraziemah Wan Zainulddin, Zalina Zabidi, Farhana Yahya, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Fezah Othman, Zarizal Suhaili and Zainul Amiruddin Zakaria. "Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats" CELLMED 2, no.4 (2012) : 34-34.
