Genuine traditional Korean medicine, BaekJeol-Tang for the treatment of rheumatoid arthritis

nara Han (한나라); 심우문; 설무창; 김민철; 이창희; 김동원; 이세훈; 이호철; 류중민; 남봉수; 김종옥; 문성오; 장현록; kim，young-suk (김영석); In Lee (이인); 양진영; 황규선; 천창선; 정현석

Genuine traditional Korean medicine, BaekJeol-Tang for the treatment of rheumatoid arthritis

CELLMED
Abbr : CellMed
2013, 3(2), pp.18-18
Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
Research Area : Medicine and Pharmacy > General Medicine

nara Han ¹, 심우문 ², 설무창 ², 김민철 ², 이창희 ², 김동원 ², 이세훈 ², 이호철 ², 류중민 ², 남봉수 ², 김종옥 ², 문성오 ², 장현록 ², kim，young-suk ², In Lee ², 양진영 ², 황규선 ², 천창선 ², 정현석 ²

¹경희대학교
²튼튼마디한의원

ABSTRACT

Inflammation in rheumatoid arthritis is characterized by immune cell infiltration and cytokine secretion. In particular, mast cells and their cytokines play an important role in the pathogenesis of rheumatoid arthritis. Korean medicine, BaekJeol-Tang (BT) was designed by traditional Korean medicine theory. We already reported therapeutic effect of BT in rheumatoid arthritis. Here, we report the specific underlying mechanism of BT in activated human mast cells, HMC-1 cells. In addition, we report for the first time that BT significantly inhibited the production and mRNA expression of proinflammatory cytokines including thymic stromal lymphopoietin, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in activated HMC-1 cells. BT also decreased the activation of mitogen-activated protein kinases, nuclear factor-κB, and caspapase-1. Taken together, these results indicate that BT has potential as a regulator of inflammatory reactions for the treatment of arthritis such as osteoarthritis and rheumatoid arthritis.

KEYWORDS

rheumatoid arthritis, BaekJeol-Tang, mast cells, caspase-1, thymic stromal lymphopoietin, ostheoarthritis

Citation status

* References for papers published after 2023 are currently being built.

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