A comparison study of the effects of loratadine-pharmacopuncture and loratadine-oral administration based on traditional Korean medicine theory on anaphylactic reaction in mice

Hyun-Min Kim; Hyun-Min Kim; Min-Jung Lee; Min-Gi Cho; Deok Kang; Yu-Kyung Kim; et al.; Phil-Dong Moon

A comparison study of the effects of loratadine-pharmacopuncture and loratadine-oral administration based on traditional Korean medicine theory on anaphylactic reaction in mice

CELLMED
Abbr : CellMed
2018, 8(1), pp.5-5
Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
Research Area : Medicine and Pharmacy > General Medicine

Hyun-Min Kim ¹, Hyun-Min Kim ¹, Min-Jung Lee ¹, Min-Gi Cho ¹, Deok Kang ¹, Yu-Kyung Kim ¹, et al. ¹, Phil-Dong Moon ¹

¹Kyung Hee University

Candidate

ABSTRACT

Pharmacopuncture, or herbal acupuncture, is a new form of therapy derived from combinations of two traditional therapeutic methods, herbal medicine and acupuncture therapy. To compare the efficacy between loratadine-pharmacopuncture (LP) and loratadine-oral administration (LO), the effect of loratadine was investigated in murine models. Anti-anaphylactic effects of loratadine treatments were investigated in compound 48/80-induced systemic anaphylactic reaction and passive cutaneous anaphylaxis (PCA). LP treatment significantly inhibited the compound 48/80-induced systemic anaphylactic reaction and PCA. The effect between LP and LO were on a similar level. These results indicate that LP can be used as an alternative method for LO in case of emergency.

KEYWORDS

loratadine-pharmacopuncture, systemic anaphylactic reaction, passive cutaneous anaphylaxis

Citation status

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[journal] Alber G / 1991 / Structure-function relationships in the mast cell high affinity receptor for IgE. Role of the cytoplasmic domains and of the beta subunit / J Biol Chem 266 : 22613~22620

[journal] Armakovic S / 2016 / Theoretical investigation of loratadine reactivity in order to understand its degradation properties: DFT and MD study / J Mol Model 22 : 240~

[journal] Chen HJ / 2010 / Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa / J Agric Food Chem 58 : 2596~2601

[journal] Han EH / 2009 / Inhibitory mechanism of saponins derived from roots of Platycodon grandiflorum on anaphylactic reaction and IgE-mediated allergic response in mast cells / Food Chem Toxicol 47 : 1069~1075

[journal] Hong SH / 2003 / Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic reaction in murine model / J Ethnopharmacol 88 : 229~234

[journal] Hu S / 2013 / Electroacupuncture at Zusanli (ST36) Prevents Intestinal Barrier and Remote Organ Dysfunction following Gut Ischemia through Activating the Cholinergic Anti-Inflammatory-Dependent Mechanism / Evid Based Complement Alternat Med 2013 : 592127~

[journal] Katelaris C / 1990 / Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis / Asian Pac J Allergy Immunol 8 : 103~107

[journal] 김재학 / 2013 / A comparison of the effects of dexamethasone-pharmacopuncture and dexamethasone-oral administration based on traditional Korean medicine theory on anaphylactic reaction in mice / 셀메드 / 셀메드 세포교정의약학회 3(3) : 24~24

[journal] 김정대 / 2010 / A Descriptive Statistical Approach to the Korean Pharmacopuncture Therapy / Journal of Acupuncture & Meridian Studies / 사단법인약침학회 3(3) : 141~149

[journal] Kim MS / 2003 / Forsythia fructus inhibits the mast-cellmediated allergic inflammatory reactions / Inflammation 27 : 129~135

[journal] Kim YY / 2017 / 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the <TEX>$Fc{\varepsilon}RI$</TEX> signaling pathway / Acta Pharmacol Sin 38 : 90~99

[journal] Kopec A / 2006 / Intracellular signaling pathways in IgE-dependent mast cell activation / Arch Immunol Ther Exp 54 : 393~401

[journal] Kreutner W / 1987 / Antiallergic activity of loratadine, a non-sedating antihistamine / Allergy 42 : 57~63

[journal] Liew FY / 2010 / Disease-associated functions of IL-33: The new kid in the IL-1 family / Nat Rev Immunol 10 : 103~110

[journal] Lu J / 2010 / Development and validation of a novel stability-indicating reversed-phase highperformance liquid chromatography method for assay of loratadine and determination of its related compounds / J AOAC Int 93 : 891~903

[journal] Metzger H / 1986 / The receptor with high affinity for immunoglobulin E / Annu Rev Immunol 4 : 419~470

[journal] Moon TC / 2014 / Mast cell mediators: their differential release and the secretory pathways involved / Front Immunol 5 : 569~

[journal] Tatemoto K / 2006 / Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors / Biochem Biophys Res Commun 349 : 1322~1328

[journal] Tiwari N / 2008 / VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways / Blood 111 : 3665~3674

[journal] Town GI / 1990 / Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma / J Allergy Clin Immunol 86 : 886~893

[journal] Wershil BK / 1987 / 125I-fibrin deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin. Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells / J Immunol 139 : 2605~2614

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