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Standardization and development of pharmacopoeial SOPs of classical Unani formulation

  • CELLMED
  • Abbr : CellMed
  • 2020, 10(2), pp.16-16
  • DOI : 10.5667/CellMed.2020.0016
  • Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
  • Research Area : Medicine and Pharmacy > General Medicine
  • Received : April 9, 2020
  • Accepted : April 22, 2020
  • Published : May 29, 2020

Mohd Nazir Mannan 1 Munawwar Husain Kazmi 2 Mohammad Zakir 3 Mohammed Abdul Rasheed Naikodi 4 Uzma Zahid 5 Javed Inam Siddiqui 2

1Department of Ilmul Advia (Pharmacology), Markaz Unani Medical College & Hospital
2Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Disorders
3Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Dis
4Quality Testing Laboratory, National Research Institute of Unani Medicine for Skin Disorder
5Department of Ilmul Advia (Pharmacology), National Research Institute of Unani Medicine for Skin Diso

Candidate

ABSTRACT

Standardization of drug deals with confirmation of drug identity and determination of drug quality and purity. Unani herbal formulations are used in traditional medicine for the treatment of various diseases. Cancer is a disease which causes abnormal, uncontrolled growth of body tissue or cells, which tend to proliferate in an uncontrolled way. Spread of cancer from site of origin to other organs of the body is called metastasis. It is a hyper proliferative disorder involving, transformation, dysregulation of apoptosis, invasion and angiogenesis. The present study aimed to standardize a classical Unani formulation (CUF) described as anticancer properties. The CUF has been used for anti-cancerous activity (Dāfiʻ-i-saraṭān) in human population by Unani physicians for centuries. The standardization parameters carried out for classical Unani formulation are pharmacognostical studies, physicochemical parameters, high-performance thin layer chromatography (HPTLC), microbial load, aflatoxins, and heavy metals revealing specific identities and to evaluate Pharmacopoeial standards. Experiment and the data obtained established the Pharmacopoeial standards for this formulation for identification and quality control purpose. The CUF has been successfully standardized and standard operating procedures (SOPs) for its preparation has been laid down which may serve as a standard reference in future. The standardization data of this formulation may be used as a standard guideline for preparation of the formulation in future.

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