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@article{ART002649412},
author={Mohd Nazir Mannan and Munawwar Husain Kazmi and Alokananda Chakraborty and Mohammad Zakir and Tasleem Ahmad and K. Lahari},
title={In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine},
journal={CELLMED},
issn={3022-6805},
year={2020},
volume={10},
number={4},
pages={27-27},
doi={10.5667/CellMed.2020.0027}

TY - JOUR
AU - Mohd Nazir Mannan
AU - Munawwar Husain Kazmi
AU - Alokananda Chakraborty
AU - Mohammad Zakir
AU - Tasleem Ahmad
AU - K. Lahari
TI - In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine
JO - CELLMED
PY - 2020
VL - 10
IS - 4
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 27
EP - 27
SN - 3022-6805
AB - Cancer is one of the leading cause of mortality in India as well as worldwide. The management of cancer by conventional therapy has shown life threatening adverse effects. The researchers are now exploring the natural way of treatment. Unani system of medicine have rich literature for cancer and many compound formulations have been described in this system. Unani system of medicine is based on holistic approach and treat human being as a unit with natural herbs, mineral and animal origin drugs. An important compound Unani formulation (CUF) from the literature has been chosen to explore the Unani claim of its anticancer activity. The phytochemical constituents were assessed using standard phytochemical screening method. Antioxidant property of this formulation was assessed by DPPH assay. The DPPH free radical scavenging assay was carried out by colorimetric method and ascorbic acid was taken as a positive control. Three different extracts of CUF on different concentrations were used to screening on human breast cancer (BCC) MCF-7 cell line. For the estimation of in-vitro cytotoxic potency of the investigated extracts was assessed on MTT assay by using trypan blue method and paclitaxel was used as the standard. Hydro-ethanolic (HE) extract showed highest free radical scavenging activity among all extracts. DPPH Assay showed substantial antioxidant activity of these extracts in hydro-ethanol extract at 1µg concentration of CUF. The CUF showed antioxidant and anticancer activity. The claim made by Unani physician has been proved.
KW - Anti-cancer Activity;Antioxidant;Breast cancer cell line;MCF-7;Saratan;DPPH Assay;MTT Assay
DO - 10.5667/CellMed.2020.0027
ER -

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad and K. Lahari. (2020). In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine. CELLMED, 10(4), 27-27.

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad and K. Lahari. 2020, "In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine", CELLMED, vol.10, no.4 pp.27-27. Available from: doi:10.5667/CellMed.2020.0027

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad, K. Lahari "In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine" CELLMED 10.4 pp.27-27 (2020) : 27.

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad, K. Lahari. In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine. 2020; 10(4), 27-27. Available from: doi:10.5667/CellMed.2020.0027

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad and K. Lahari. "In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine" CELLMED 10, no.4 (2020) : 27-27.doi: 10.5667/CellMed.2020.0027

Mohd Nazir Mannan; Munawwar Husain Kazmi; Alokananda Chakraborty; Mohammad Zakir; Tasleem Ahmad; K. Lahari. In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine. CELLMED, 10(4), 27-27. doi: 10.5667/CellMed.2020.0027

Mohd Nazir Mannan; Munawwar Husain Kazmi; Alokananda Chakraborty; Mohammad Zakir; Tasleem Ahmad; K. Lahari. In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine. CELLMED. 2020; 10(4) 27-27. doi: 10.5667/CellMed.2020.0027

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad, K. Lahari. In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine. 2020; 10(4), 27-27. Available from: doi:10.5667/CellMed.2020.0027

Mohd Nazir Mannan, Munawwar Husain Kazmi, Alokananda Chakraborty, Mohammad Zakir, Tasleem Ahmad and K. Lahari. "In-Vitro Anticancer and Free Radical Scavenging Potential of Compound Formulation Used in Unani System of Medicine" CELLMED 10, no.4 (2020) : 27-27.doi: 10.5667/CellMed.2020.0027