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@article{ART003019184},
author={Hee-Yun Kim and Hyunwoo Jee and Hosong Cho and Dongjun Park and Hyun-Ja Jeong},
title={A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice},
journal={CELLMED},
issn={3022-6805},
year={2023},
volume={13},
number={14},
pages={2-2},
doi={10.5667/CellMed.2023.015}

TY - JOUR
AU - Hee-Yun Kim
AU - Hyunwoo Jee
AU - Hosong Cho
AU - Dongjun Park
AU - Hyun-Ja Jeong
TI - A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice
JO - CELLMED
PY - 2023
VL - 13
IS - 14
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 2
EP - 2
SN - 3022-6805
AB - Background and objective: A new formular CPC22 consists of Cynanchum wilfordii root, Pueraria thomsonii flower, and Citrus unshiu peel and has been developed to improve the postmenopausal symptoms. The research intended to evaluate whether CPC22 would regulate bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized (OVX) postmenopausal mice. Method: The OVX mice were orally administered with CPC22 daily for 7 weeks. Results: CPC22 regulated OVX-induced bon loss by enhancing serum osteoprotegerin, alkaline phosphatase, and osteocalcin levels and diminishing serum receptor-activator of the NF-κB ligand (RANKL), collagen type 1 cross-linked N-telopeptide, and tartrate-resistant acid phosphatase levels. As a result of CPC22 treatment, notable decreases in tail skin temperature and rectal temperature were observed, along with diminishment in hypothalamic RANKL and monoamine oxidase A levels and enhancement in hypothalamic serotonin (5-HT), norepinephrine, dopamine, 5-HT2A, and estrogen receptor-β levels. CPC22 enhanced levels of serum estrogen and diminished levels of serum follicle-stimulating hormone and luteinizing hormone. CPC22 regulated levels of serum lipid metabolites, including total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Furthermore, CPC22 diminished levels of serum blood urea nitrogen, creatine kinase, alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase and restored vaginal dryness without affecting uterus atrophy index and vagina weights. Conclusion: Therefore, these results indicated that CPC22 improves OVX-induced bone loss, hot flashes, and dysregulated lipid metabolism by compensating for estrogen deficiency without side effects, suggesting that CPC22 may be used for the prevention and treatment of post menopause.
KW - CPC22;postmenopause;osteoporosis;hot flashes;lipid metabolites
DO - 10.5667/CellMed.2023.015
ER -

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park and Hyun-Ja Jeong. (2023). A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice. CELLMED, 13(14), 2-2.

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park and Hyun-Ja Jeong. 2023, "A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice", CELLMED, vol.13, no.14 pp.2-2. Available from: doi:10.5667/CellMed.2023.015

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park, Hyun-Ja Jeong "A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice" CELLMED 13.14 pp.2-2 (2023) : 2.

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park, Hyun-Ja Jeong. A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice. 2023; 13(14), 2-2. Available from: doi:10.5667/CellMed.2023.015

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park and Hyun-Ja Jeong. "A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice" CELLMED 13, no.14 (2023) : 2-2.doi: 10.5667/CellMed.2023.015

Hee-Yun Kim; Hyunwoo Jee; Hosong Cho; Dongjun Park; Hyun-Ja Jeong. A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice. CELLMED, 13(14), 2-2. doi: 10.5667/CellMed.2023.015

Hee-Yun Kim; Hyunwoo Jee; Hosong Cho; Dongjun Park; Hyun-Ja Jeong. A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice. CELLMED. 2023; 13(14) 2-2. doi: 10.5667/CellMed.2023.015

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park, Hyun-Ja Jeong. A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice. 2023; 13(14), 2-2. Available from: doi:10.5667/CellMed.2023.015

Hee-Yun Kim, Hyunwoo Jee, Hosong Cho, Dongjun Park and Hyun-Ja Jeong. "A new formula CPC22 regulates bone loss, hot flashes, and dysregulated lipid metabolism in ovariectomized postmenopausal mice" CELLMED 13, no.14 (2023) : 2-2.doi: 10.5667/CellMed.2023.015