@article{ART003306148},
author={Bong-geun Jang and Seong-Hoon Yun and Hye-Yeon Kang and Sunyoung Park and Gun-Woo Lee},
title={Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model},
journal={CELLMED},
issn={3022-6805},
year={2026},
volume={16},
number={2},
pages={17-22},
doi={10.5667/CellMed.2026.003}
TY - JOUR
AU - Bong-geun Jang
AU - Seong-Hoon Yun
AU - Hye-Yeon Kang
AU - Sunyoung Park
AU - Gun-Woo Lee
TI - Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model
JO - CELLMED
PY - 2026
VL - 16
IS - 2
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 17
EP - 22
SN - 3022-6805
AB - Objective: This study evaluated the analgesic efficacy of "Flucoxfen", a flurbiprofen plaster enriched with natural berry-herb oils, compared to a conventional plaster in a Complete Freund’s Adjuvant (CFA)-induced rat model.
Materials and Methods: Twenty rats were assigned to Normal, Control (CFA), Flucoxfen, and J Plaster groups. Daily applications of plasters were made to the inflamed paw. Mechanical hyperalgesia (von Frey test) and functional weight-bearing were assessed on days 4 and 10.
Results: Flucoxfen significantly alleviated pain, increasing the paw withdrawal threshold by 122% (Day 4) and 193% (Day 10) compared to the Control group (*p < 0.05). Additionally, it restored weight-bearing balance by 44% on Day 10 and markedly reduced edema. In contrast, the conventional plaster exhibited minimal therapeutic effects.
Conclusion: The incorporation of berry-herb oils significantly enhances the transdermal delivery and anti-inflammatory efficacy of flurbiprofen. Flucoxfen presents a potent therapeutic alternative for severe inflammatory pain where standard topical formulations are insufficient.
KW - Osteoarthritis;Flurbiprofen;Essential Oils;Inflammatory Pain;Transdermal Drug Delivery;Permeation Enhancer
DO - 10.5667/CellMed.2026.003
ER -
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park and Gun-Woo Lee. (2026). Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model. CELLMED, 16(2), 17-22.
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park and Gun-Woo Lee. 2026, "Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model", CELLMED, vol.16, no.2 pp.17-22. Available from: doi:10.5667/CellMed.2026.003
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Gun-Woo Lee "Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model" CELLMED 16.2 pp.17-22 (2026) : 17.
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Gun-Woo Lee. Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model. 2026; 16(2), 17-22. Available from: doi:10.5667/CellMed.2026.003
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park and Gun-Woo Lee. "Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model" CELLMED 16, no.2 (2026) : 17-22.doi: 10.5667/CellMed.2026.003
Bong-geun Jang; Seong-Hoon Yun; Hye-Yeon Kang; Sunyoung Park; Gun-Woo Lee. Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model. CELLMED, 16(2), 17-22. doi: 10.5667/CellMed.2026.003
Bong-geun Jang; Seong-Hoon Yun; Hye-Yeon Kang; Sunyoung Park; Gun-Woo Lee. Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model. CELLMED. 2026; 16(2) 17-22. doi: 10.5667/CellMed.2026.003
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park, Gun-Woo Lee. Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model. 2026; 16(2), 17-22. Available from: doi:10.5667/CellMed.2026.003
Bong-geun Jang, Seong-Hoon Yun, Hye-Yeon Kang, Sunyoung Park and Gun-Woo Lee. "Enhanced Analgesic Efficacy of Flurbiprofen Plaster Supplemented with Natural Berry Herb Oil in a CFA-Induced Inflammatory Pain Model" CELLMED 16, no.2 (2026) : 17-22.doi: 10.5667/CellMed.2026.003
