@article{ART003372367},
author={Seong-Been Yang and Na-Rae Kim and Hyun-Ja Jeong},
title={Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice},
journal={CELLMED},
issn={3022-6805},
year={2026},
volume={16},
number={5},
pages={1-7},
doi={10.5667/OCNT.2026.008}
TY - JOUR
AU - Seong-Been Yang
AU - Na-Rae Kim
AU - Hyun-Ja Jeong
TI - Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice
JO - CELLMED
PY - 2026
VL - 16
IS - 5
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 1
EP - 7
SN - 3022-6805
AB - Objective: Chronic stress is a primary precipitating factor for depressive disorders, linked to central monoaminergic deficits, impaired neuroplasticity, and systemic inflammation. This study investigated the antidepressant-like efficacy and underlying molecular mechanisms of Daegeum music therapy (DMT), a traditional Korean bamboo flute acoustic intervention, in a mouse model of depression.
Materials and Methods: Mice were subjected to chronic stress and exposed to daily DMT for 3 weeks.
Results: Behavioral assessments demonstrated that DMT significantly reduced immobility times in the forced swimming test without altering general locomotor activity. Notably, this behavioral rescue was acoustically specific to DMT, as white noise and Buk music failed to alleviate behavioral despair. Mech-anistically, DMT remarkably prevented stress-induced neurotransmitter deficits by restoring serotonin and dopamine levels within the hippocampus. Furthermore, Western blot analysis revealed that DMT ro-bustly up-regulated hippocampal brain-derived neurotrophic factor expression and selectively promoted extracellular signal-regulated kinase phosphorylation, thereby stimulating neuroplastic signaling cas-cades. Beyond central remodeling, DMT exerted potent peripheral anti-inflammatory effects by down-regulating pro-inflammatory cytokines.
Conclusion: Taken together, these findings demonstrate that DMT effectively mitigates depressive-like behaviors by restoring hippocampal monoaminergic homeostasis, stimulating neuroplastic cascades, and suppressing systemic inflammatory pathways, highlighting its therapeutic potential as a non-pharmacological acoustic intervention.
KW - DMT;depression;serotonin;neuroplasticity;BDNF;pro-inflammatory cytokines
DO - 10.5667/OCNT.2026.008
ER -
Seong-Been Yang, Na-Rae Kim and Hyun-Ja Jeong. (2026). Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice. CELLMED, 16(5), 1-7.
Seong-Been Yang, Na-Rae Kim and Hyun-Ja Jeong. 2026, "Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice", CELLMED, vol.16, no.5 pp.1-7. Available from: doi:10.5667/OCNT.2026.008
Seong-Been Yang, Na-Rae Kim, Hyun-Ja Jeong "Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice" CELLMED 16.5 pp.1-7 (2026) : 1.
Seong-Been Yang, Na-Rae Kim, Hyun-Ja Jeong. Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice. 2026; 16(5), 1-7. Available from: doi:10.5667/OCNT.2026.008
Seong-Been Yang, Na-Rae Kim and Hyun-Ja Jeong. "Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice" CELLMED 16, no.5 (2026) : 1-7.doi: 10.5667/OCNT.2026.008
Seong-Been Yang; Na-Rae Kim; Hyun-Ja Jeong. Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice. CELLMED, 16(5), 1-7. doi: 10.5667/OCNT.2026.008
Seong-Been Yang; Na-Rae Kim; Hyun-Ja Jeong. Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice. CELLMED. 2026; 16(5) 1-7. doi: 10.5667/OCNT.2026.008
Seong-Been Yang, Na-Rae Kim, Hyun-Ja Jeong. Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice. 2026; 16(5), 1-7. Available from: doi:10.5667/OCNT.2026.008
Seong-Been Yang, Na-Rae Kim and Hyun-Ja Jeong. "Daegeum music therapy alleviates depression-like behaviors via the restoration of monoaminergic and neurotrophic systems in mice" CELLMED 16, no.5 (2026) : 1-7.doi: 10.5667/OCNT.2026.008
