Behavioral activation/inhibition systems and self-control are associated with a wide range of psychological disorders. The purpose of this study is to understand the psychological mechanisms underlying many psychological problems, especially the role of behavioral activation/inhibition systems and self-control in psychological problems. In particular, it sought to empirically verify whether two-mode models of self-regulation proposed by Carver et al. (2008) could explain various forms of psychological maladjustment. For this purpose, the present study explored the relationship of behavioral inhibition system(BIS), behavioral activation system(BAS), self-control, internalization problems (e.g., depression, anxiety), and externalization problems (e.g., aggression). A total of 435 undergraduate participants completed BIS/BAS Scale, Brief Self-Control Scale, Aggression Questionnaire, Center for Epidemiologic Studies Depression Scale, the State-Trait Anxiety Inventory. The results showed that the behavioral inhibition and behavioral activation systems have significant correlations with depression, anxiety, and aggression. Furthermore, the behavioral inhibition system, behavioral activation system, and self-control significantly predicted depression, state anxiety and aggression differently. Finally, self-control significantly moderated the relationship between the behavioral inhibition system and depression, and the relationship between the behavioral inhibition system and state anxiety. However, regarding the relationship between the behavioral activation system and aggression, the moderating effect of self-control was not significant. Based on these results, the implications and limitations of this study are discussed.