@article{ART001670138},
author={Lee, Jong-Kook and 고영화 and 이난희},
title={Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones},
journal={Journal of the Korean Crystal Growth and Crystal Technology},
issn={1225-1429},
year={2012},
volume={22},
number={3},
pages={139-146},
doi={10.6111/JKCGCT.2012.22.3.139}
TY - JOUR
AU - Lee, Jong-Kook
AU - 고영화
AU - 이난희
TI - Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones
JO - Journal of the Korean Crystal Growth and Crystal Technology
PY - 2012
VL - 22
IS - 3
PB - The Korea Association Of Crystal Growth, Inc.
SP - 139
EP - 146
SN - 1225-1429
AB - Natural hydroxyapatite powder was obtained from the calcination of bovine bones and its porous compacts were fabricated by pressureless sintering at 1100 and 1200oC for 1h. To evaluate and compare their biocompatibility with porosity, we investigated the support of osteoblast cells growth and cytotoxicity using the MG-63 cell line model in vitro.
Sintered hydroxyapatite ceramics have a porous microstructure with a relative density of 65 % at 1100oC and 82 % at 1200oC. Cells adherence to the surface of hydroxyapatite ceramics was observed in a day after the cell culture, and the spreading of cytoplasm around the nucleus was shown after 3 day cell culture. Most of cells were extended to the surface of hydroxyapatite through the wide area. Cell viability was nearly the same till 3 days culturing. But the rate of cell growth is higher in the specimen sintered at 1100oC than that of 1200oC. It indicates that the porosity is an important factor to enhance the cell viability in the porous hydroxyapatite ceramics derived from bovine bones.
KW - Hydroxyapatite;Biocompatibility;Bovine bone;Porosity
DO - 10.6111/JKCGCT.2012.22.3.139
ER -
Lee, Jong-Kook, 고영화 and 이난희. (2012). Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones. Journal of the Korean Crystal Growth and Crystal Technology, 22(3), 139-146.
Lee, Jong-Kook, 고영화 and 이난희. 2012, "Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones", Journal of the Korean Crystal Growth and Crystal Technology, vol.22, no.3 pp.139-146. Available from: doi:10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook, 고영화, 이난희 "Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones" Journal of the Korean Crystal Growth and Crystal Technology 22.3 pp.139-146 (2012) : 139.
Lee, Jong-Kook, 고영화, 이난희. Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones. 2012; 22(3), 139-146. Available from: doi:10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook, 고영화 and 이난희. "Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones" Journal of the Korean Crystal Growth and Crystal Technology 22, no.3 (2012) : 139-146.doi: 10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook; 고영화; 이난희. Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones. Journal of the Korean Crystal Growth and Crystal Technology, 22(3), 139-146. doi: 10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook; 고영화; 이난희. Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones. Journal of the Korean Crystal Growth and Crystal Technology. 2012; 22(3) 139-146. doi: 10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook, 고영화, 이난희. Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones. 2012; 22(3), 139-146. Available from: doi:10.6111/JKCGCT.2012.22.3.139
Lee, Jong-Kook, 고영화 and 이난희. "Biocompatibility of porous hydroxyapatite ceramics prepared from bovine bones" Journal of the Korean Crystal Growth and Crystal Technology 22, no.3 (2012) : 139-146.doi: 10.6111/JKCGCT.2012.22.3.139
