Clinical research methodology for Traditional Korean Medicine treatment of lung cancer : Evidence-based approach (肺癌의 한방치료 임상연구 방법론 )

김경석; Sehyun Kim (김세현); EO WAN KYU (어완규); 전성하; Eom Seok-ki (엄석기); Jo, Hak-Jun (조학준)

Clinical research methodology for Traditional Korean Medicine treatment of lung cancer : Evidence-based approach

The Journal Of Korean Medical Classics
Abbr : JKMC
2010, 23(4), pp.39~62
Publisher : 대한한의학원전학회
Research Area : Medicine and Pharmacy > Korean Medicine

김경석 ¹, Sehyun Kim ², EO WAN KYU ³, 전성하 ⁴, Eom Seok-ki ⁵, Jo, Hak-Jun ⁶

¹경희대학교 동서신의학병원 M·μ 통합암센터 한방내과.
²경희대학교
³경희대학교 동서신의학병원 통합암센터 혈액종양내과
⁴경희대학교 동서신의학병원 혈액종양내과
⁵광혜원 한방병원
⁶세명대학교

Accredited

ABSTRACT

Background : I investigated clinical research methodology of Traditional Korean Medicine(TKM) for treatment of lung cancer with Evidence Based Medicine(EBM) approach. Methods : I conducted the internet search of National Central Library, the National Assembly Library, Korea Education & Research Information Service, Korea Institute of Science and Technology Information for Korean theses and papers, and MEDLINE for the outside articles. Conclusion : In addition to outcomes of clinical trial, abundant clinician's experience and patients' preference are also considered. Pragmatic trials and quasi-experimental trials are better than clinical trials to plan clinical design of TKM for lung cancer and appropriate endpoints includes overall survival, disease-free survival, patient reporting outcome.

KEYWORDS

evidence based medicine, lung cancer, Traditional Korean Medicine, methodology.

Citation status

* References for papers published after 2023 are currently being built.

[book] 대한 내과학회 / 2006 / 해리슨 내과학 16판 / MIP : 546~559

[book] 박재갑 / 2003 / 종양학 / 일조각 : 284~325

[book] David L. Sackett / 2004 / 근거중심의학 / 아카데미아 : 141~143

[journal] 강락원 / 2003 / Cell Cycle Arrest of Human Lung Carcinoma A549 Cells by an Aqueous Extract from the Roots of Platycodon grandiflorum / 대한한방내과학회지 spr(1) : 62~72

[journal] 곽정진 / 2002 / A Clinical Report on the Pifeiliangxu Type of Lung Cancer Patient by case study / 대한한방내과학회지 / 대한한방내과학회 23(3) : 486~496

[journal] 김민경 / 2009 / 쑥뜸 치료로 호전된 비소세포성폐암 환자의 암성통증 1례 / 대한암한의학회지 14(1) : 53~59

[journal] 김재연 / 2002 / A Clinical Report on the Pifeiliangxu Type of Lung Cancer Patient by case study / 대한한방내과학회지 aut(1) : 144~152

[journal] 김정근 / 2005 / 폐암으로 진단받은 환자의 호흡곤란과 해수 호전 1례 / 대한한방내과학회지 spr(1) : 255~261

[journal] 김진영 / 2008 / Effect of Gamisamgibopae-tang on the Growth and Apoptosis of A539 and NCI-H460 Human Lung Cancer Cells / 대한한방내과학회지 / 대한한방내과학회 29(1) : 130~148

[journal] 나동규 / 1998 / 폐옹(肺癰)에 대한 문헌적 고찰 / 대전대학교 한의학연구소 논문집 13 : 775~782

[journal] 박봉기 / 2009 / One Clinical Case Report of Lung Cancer Patient with Dyspnea Prescribed / 대한한방내과학회지 30(1) : 233~240

[journal] 박봉기 / 2007 / A Case Report for Stage ⅢB Squamous Cell Lung Carcinoma Patient Treated with Cultured Wild Ginseng Pharmacopuncture Therapy / 대한약침학회지 / 대한약침학회 10(3) : 143~147

[journal] 박정섭 / 2005 / A Clinical Report of the Patientwith Limited-Stage Small Cell Lung Cancer / 대한한방내과학회지 / 대한한방내과학회 26(3) : 677~684

[journal] 박정희 / 1995 / 폐암의 한의치료에 관한 문헌적 고찰 / 대한한의학회지 16(1) : 71~95

[journal] 방대건 / 2007 / Induction of Apoptosis by Realgar on Lung Cancer Cells(A549), Stomach Cancer Cells(KATO) and Neuroglioma Cells(SNU-1118, U-87MG, U-373MG) / 대한한방내과학회지 / 대한한방내과학회 28(2) : 294~305

[journal] 방선휘 / 2008 / Two Cases of Non-Small Cell Lung Cancer Treated with Intravenous Cultivated Wild Ginseng Extract / 대한약침학회지 / 대한약침학회 11(2) : 13~20

[other] 배기채 / 1997 / 폐암의 변증과 치방에 관한 문헌적 고찰 / 대전대학교 한의학연구소 논문집 : 243~264

[journal] 손지영 / 2009 / One Clinical Case Report of Lung Cancer Patient with Dyspnea Prescribed / 대한한방내과학회지 / 대한한방내과학회 30(1) : 233~240

[journal] 오태환 / 1991 / 폐암에 관한 동서의학적 문헌 고찰 / 대한 한의학회지 12(2) : 52~65

[journal] 유승민 / 2008 / 알러젠 제거 옻나무 추출물 투여로 삶의 질 개선과 생존기간 연장을 보인 비소세포성 폐암 환자 1례 / 대한암한의학회지 13 : 63~69

[journal] 유승후 / 2007 / A Case Report for Recurred Squamous Cell Lung Carcinoma Treated with Hang-Am-Dan: 7-year follow-up / 대한한방내과학회지 / 대한한방내과학회 28(2) : 387~392

[journal] 이동건 / 1992 / 폐옹의 치료에 관한 문헌적 고찰 / 대한한의학회지 13(1) : 9~22

[journal] 이병호 / 2004 / Antitumor Effect of Gagamjengac-tang and As2O3 in Human Lung Cancer Cell Line, H-157 / 대한한의학회지 / 대한한의학회 25(3) : 191~202

[journal] 이선행 / 2009 / 반하백 출천마탕 가감방을 투여하여 비소세포성폐암의 뇌전이에 의한 두통이 호전된 1례 / 대한암한의학회지 14(1) : 45~52

[journal] 이승언 / 2004 / 肺癌 세포주 H460에 補中益氣湯이 미치는 세포괴사 효과 및 기전 연구 / 대한한방내과학회지 24(4) : 278~288

[journal] 이충섭 / 2002 / Effects of Gagamgilgyung-tang on the Proliferation and Apoptosis of Human Lung Cancer Cell / 대한한의학회지 / 대한한의학회 23(1) : 24~36

[journal] 전종철 / 2008 / Effect of Several Herbal Medicines on Atopic Dermatitis Patients' SCORAD and Cytokine Levels / 대한한방내과학회지 28(2) : 321~332

[journal] 정의민 / 2009 / A Case Report of Regressed Metastatic Brain Tumors and Prolongation of Life with Allergen Removed Rhus verniciflua Stokes after Gamma Knife Radiosurgery / 대한한의학회지 / 대한한의학회 30(5) : 157~162

[journal] 최재호 / 2005 / 한약에 의한 소세포성 폐암의 퇴축; 8년간의 추적조사를 통한 증례보고 / 대한암한의학회지 10(1) : 87~91

[journal] 한재수 / 1994 / 肺積肺癰肺疽肺癌에 關한 文獻的考察;原因·症狀中心으로 / 대한한의학회지 15(1) : 26~35

[journal] 허만규 / 2007 / Induction of Apoptosis by Samgibopae-tang in Human Non-small-cell Lung Cancer Cells / 대한한방내과학회지 / 대한한방내과학회 28(3) : 473~491

[journal] 황충연 / 1995 / 폐암의 동서의결합치료에 관한 문헌적고찰 / 대한한의학회지 16(2) : 177~194

[journal] 박재석 / 2008 / Effect of Salvia miltiorrhiza Extract in Urethane-induced Lung Tumorigenesis in A/J Mice / 대한한방내과학회지 / 대한한방내과학회 29(3) : 595~607

[other] 서동진 / 1997 / 한의학의 연구방법론에 관한 고찰 / 대한예방한의학회지 : 14~26

[thesis] 최한수 / 1999 / 한의학 방법론에 관한 고찰 / 박사 / 대전대학교

[other] 김광중 / 1988 / 한의학의 연구방법 / 동서의학 : 10~14

[journal] 유병완 / 2008 / A Study on the Methology of Oriental Medicine / 대한한의학원전학회지 / 대한한의학원전학회 21(4) : 133~160

[journal] 김환 / 2003 / Development and Validation of Korean Functional Assessment Cancer Therapy-General(FACT-G) / 한국심리학회지 임상 / 한국임상심리학회 22(1) : 215~229

[journal] JaeHyun Park / 2008 / Brief review of cancer treatment focused on JIJU / J of Kor.Traditional Oncology 13 : 1~11

[journal] 엄석기 / 2008 / Disease Recognition of Tumor, Bump or Mass until Han Dynasty / 대한한의학원전학회지 / 대한한의학원전학회 21(2) : 39~48

[journal] 엄석기 / 2008 / On Estimation of Indication, Property and Processing of Rhus Verniciflua Stokes / 대한한의학원전학회지 / 대한한의학원전학회 21(2) : 29~38

[journal] Back Sangryoung / 2002 / A study of guideline in writing a protocol of clinical trials in orient medicine / Korean Journal of oriental medicine 8(2) : 37~46

[journal] Andrew F. Long / 2002 / Outcom e measurement in complementary and alternative medicine: unpicking the effects / The Journal of Alternative and Complementary Medicine 8(6) : 777~786

[journal] Ramzi Dagher / 2004 / Accelerated approval of oncology products: a decade of experience / Journal of the National Cancer Institute 96(20) : 1500~1509

[journal] Bradley C / 2004 / N-of-1 randomized controlled trials: An opportunity for complementary and alternative medicine evaluation / The Journal of Alternative and Complementary Medicine 10(6) : 979~984

[journal] Britton A / 1998 / Choosing between randomised and non-randomised studies: a systemic review / Health Technology Assess 2(13) : 1~124

[journal] Center for Drug Evaluation and Research / 2008 / Endpoints for assessing drug activity in clinical trials / The Oncologist 13(suppl2) : 19~21

[journal] Cornelis J. A. Punt / 2007 / Endpoints in adjuvant treatment trials: a systemic review of the literature in colon cancer and proposed definitions for future trials / J Natl Cancer Inst 99 : 998~1003

[journal] David Moher / 2001 / The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials / The Lancet 357 : 1191~1194

[journal] Ezzo J / 2001 / How strong is the evidence? How clear are the conclusion? / Int J Technol Assess Health Care 17 : 457~466

[journal] Gribbons, Barry / 1997 / True and quasi-experimental designs / Practical Assessment,Research & Evaluation 5(14)

[journal] Jeremy Grimshow / 2000 / Experimental and quasiexperimental designs for evaluating guideline implementation strategies / Family Practice 17 : 11~18

[journal] Joel J Gannier / 2006 / Reporting randomized, controlled trials of herbal interventions:an elaborated CONSORT statement / Ann Inrern Med 144 : 364~367

[journal] John R. Johnson / 2003 / End points and United States Food and Drug Administration approval of oncology drugs / J Clin Oncol 21(7) : 1404~1411

[journal] Kent R Johnson / 2006 / Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small cell lung cancer: meta-analysis / Lancet Oncol 7 : 741~746

[journal] Kjell Benson / 2000 / A comparison of observational studies and randominzed, controlled trials / NEJM 342 : 1878~1886

[journal] Lee SH / 2009 / Successful outcome of advanced pulmonary adenocarcinoma with malignant pleural effusion by the standardized rhus verniciflua stokes extract: a case study / Explore 5(4) : 242~244

[journal] Lillian Sung / 2006 / N-of-1 Trials: Innovative methods to evaluate complementary and alternative medicines in pediatric cancer / J Pediatr Hematol Oncol 28(4) : 263~266

[journal] Marja J Verhoef / 2006 / Evaluating complementary and alternative medicine inter-ventions: in search of appropriate patient-centered outcome measures / BMC Complementary and Alternative Medicine 6 : 38~

[journal] Marja J. Verhoef / 2005 / Complementary and alternative medicine whole systems research: beyond identification of inadequacies of the RCT / Complementary Therapies in Medicine 13 : 206~212

[journal] Oken, M.M / 1982 / Toxicity and response criteria of The Easten Cooperative Oncology Group / Am J Clin Oncol 5 : 649~655

[journal] Patrick Therasse / 2000 / New Guidelines to evaluate the response to treatment in solid tumor / Journal of National Cancer Institute 92(3) : 206~216

[journal] Peter Goldstraw / 2007 / The IASLC lung cancer staging project:proposals for the revision of the TNM stage groupings in the forthcoming(seventh) edition of the TNM classification of malignant tumor / J Thorac Oncol 2 : 706~714

[journal] Regina P. El Dib / 2007 / Mapping the Cochrane evidence for decision making in health care / Jounal of Evaluation in Clinical Practice 13 : 689~692

[journal] Tomasz Burzykowski / 2008 / Evaluation of tumor response, disease control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast Cancer / J Clin Oncol 26(12) : 1987~1992

[confproc] Kim SH / 2007 / Effect of Nexia for Advanced Non-small cell Lung Cancer on Patient’'s Survival and Quality of Life: a Prospective Cohort Study / The 2nd International East-West Cancer Symposium

[web] / http://www.cancer.gov/cancertopics/pdq/levels-evidence-cam/HealthProfessional/allpages/print#Section_21 / http://www.cancer.gov/cancertopics/pdq/levels-evidence-cam/HealthProfessional/allpages/print#Section_21

[web] / What is cancer? / National cancer institute / http://www.cancer.gov/cancertopics/what-is-cancer

[web] / http://www.nccn.org/professionals/physician_gls/f_guidelines.asp / http://www.nccn.org/professionals/physician_gls/f_guidelines.asp

[other] 한국 통계청 / 2008 / 2007년 사망 및 사망원인 통계결과

[web] / http://clinicaltrials.kfda.go.kr/guide/info6.jsp / http://clinicaltrials.kfda.go.kr/guide/info6.jsp.

[other] 보건복지가족부 / 2009년 보건복지가족통계연보

KJCKorea
Journal Central

The Journal Of Korean Medical Classics 2023 KCI Impact Factor : 0.29