2017, Vol.27, No.1

Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6

pISSN : 1229-1854
https://journal.kci.go.kr/jkmr

ObjectivesThis study aimed to investigate the effect of Bangkibokryeong-tang (BBT, Fangjifuling-tang) on blood glucose and body fat in high-fat diet-induced obese mice.MethodsThe experimental animals were divided into five groups- normal diet-fed control (ND), high-fat diet-fed control (HFD), HFD+BBT 75, HFD+BBT 150, and HFD+olistat as a positive drug control group. Markers of obesity, such as body weight, organ weight, diet ef-ficiency, and serum levels of total cholesterol, triglycerides, lipid content, leptin, adipo-nectin, glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transferase (GPT)/lactate dehydrogenase (LDH), blood glucose, and insulin, were measured. Furthermore, results of the oral glucose tolerance test and α-glucosidase inhibition activity were examined in obese mice.ResultsMice treated with BBT demonstrate lower body and organ weight, and reduced weight gain and food efficiency than that in the HFD-only control group. In addition, BBT decreased lipid accumulation in the liver and the levels of enzymes such as GOT, GPT, and LDH in the serum. Furthermore, the levels of triglycerides, total cholesterol, low density lip-oprotein (LDL), and leptin were decreased in the serum but the levels of high density lip-oprotein (HDL) and adiponectin were increased in the BBT-treated group compared with the control group. The BBT-treated group also demonstrated decreased blood glucose and in-sulin concentrations induced by feeding on a high-fat diet and improved glucose tolerance.ConclusionsBased on the results above, BBT may reduce body fat and hyperglycemia in HFD-induced obesity. This suggests that BBT may be clinically useful in the treatment of obesity. (J Korean Med Rehabil 2017;27(1):1-17)

ObjectivesEucommiae cortex is one of the frequently used herbs for musculoskeletal disorders, with well-known anti-inflammatory effect. Meanwhile, powdered form of herbal drugs is more advantageous than decoction form, in that storing and taking is more convenient. Thus, the authors aimed to investigate whether the drying method affects the index compound level and anti-inflammatory effect of eucommiae cortex water extract.MethodsEucommiae cortex was extracted in distilled water at 100oC for 3 hours, filtered, and then evaporated under vacuum. One half of the sample was freeze-dried at −80oC. Another half of the sample was added with dextrin and then spray-dried at 180oC. To as-sess the possible change in index compound content, pinoresinol diglucoside was selected as the index marker. The content level of the index compound in various extract sample was quantified through high performance liquid chromatography. In addition, iNOS assay in LPS-induced RAW 264.7 cells was adopted to determine the anti-inflammatory effect of various extract samples. Furthermore, MTT assay was performed to confirm that the result of iNOS assay was not due to cytotoxicity.ResultsThere was no significance difference in index compound content between ex-tract samples obtained through two different drying methods. Anti-inflammatory activity of extract samples were similar at the matching concentration, regardless of the drying methods. Extract samples did not show any significant cytotoxicity.ConclusionsExtract samples of eucommiae cortex were obtained through freeze-drying and spray-drying. Neither change in index compound content nor difference in anti-in-flammatory activity was observed between drying methods. (J Korean Med Rehabil 2017;27(1):19-25)

ObjectivesThis study aimed to review case studies on interventions of Korean medicine for hip pain.MethodsWe searched seven electronic databases for relevant studies up to Oct 2016. Case studies of Korean medicine interventions for hip pain were included and analysed.Results15 case studies were included (Korean databases; n=15) and Total number of patients was 17 cases. A total of 13 types of interventions were reported, of which acu-puncture (93.3%), herbal medicine (80.0%) and pharmacopuncture (40.0%) were the most frequently used. GB30 (66.7%), LR3 (41.7%), BL36 (33.3%) and ST31 (33.3%) were used in at least 4 papers. Cheongpa-jeon (25.0%) and symptom change (46.7%) were most fre-quently used in herbal medicine and outcome measure respectively.ConclusionsClinical studies, especially double-blinded randomized controlled trials, of Korean medicine interventions for hip pain must be conducted to obtain definite conclusions. (J Korean Med Rehabil 2017;27(1):27-35)