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@article{ART001083344},
author={신승우 and Sungsoo Kim},
title={Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2007},
volume={17},
number={3},
pages={65-89}

TY - JOUR
AU - 신승우
AU - Sungsoo Kim
TI - Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects
JO - Journal of Korean Medicine Rehabilitation
PY - 2007
VL - 17
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 65
EP - 89
SN - 1229-1854
AB - Objectives : This study was conducted to investigate the effects of UCP-1(Uncoupling protein-1) polymorphism on obesity phenotypes. For this, we analyzed association between SNPs(single nucleotide polymorphisms) of UCP-1 -3954A>G, -1766A>G, +940A>G, +6537A>T, and their haplotypes and obesity phenotypes. Methods： A total of 426 Korean female subjects were recruited from an obesity clinic. All subjects were obesity on BMI(Body mass index) (≧25 ㎏/㎡). For genotyping of SNPs, genomic DNA(Deoxyribonucleic acid) from each subject was extracted from whole blood and genotyped by TaqMan Method. Haplotypes and their frequencies were inferred using the algorithm, HapAnalyzer program. BMI, body fat mass, percent body fat, abdominal fat mass, waist circumference, lipid profile, and blood pressure were measured and associations between these and SNPs and haplotypes of UCP-1 were analyzed by age-adjusted general linear model. Results & Conclusions： There was significant, but not close association between -3954A>G, +940G>A, and haplotype 1-3 of UCP-1 with increased body fat of Korean female subjects. It was found that body fat mass and other obesity phenotype were significantly increased in G allele carriers of -1766A>G polymorphism, while decreased in T allele carriers of +6537A>T polymorphism and haplotype4[GAAT] carriers.
KW - UCP-1;Polymorphism;Obesity;Korean female
DO -
UR -
ER -

신승우 and Sungsoo Kim. (2007). Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects. Journal of Korean Medicine Rehabilitation, 17(3), 65-89.

신승우 and Sungsoo Kim. 2007, "Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects", Journal of Korean Medicine Rehabilitation, vol.17, no.3 pp.65-89.

신승우, Sungsoo Kim "Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects" Journal of Korean Medicine Rehabilitation 17.3 pp.65-89 (2007) : 65.

신승우, Sungsoo Kim. Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects. 2007; 17(3), 65-89.

신승우 and Sungsoo Kim. "Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects" Journal of Korean Medicine Rehabilitation 17, no.3 (2007) : 65-89.

신승우; Sungsoo Kim. Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects. Journal of Korean Medicine Rehabilitation, 17(3), 65-89.

신승우; Sungsoo Kim. Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects. Journal of Korean Medicine Rehabilitation. 2007; 17(3) 65-89.

신승우, Sungsoo Kim. Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects. 2007; 17(3), 65-89.

신승우 and Sungsoo Kim. "Association Study between UCP-1 Polymorphismsand Korean Obese Female Subjects" Journal of Korean Medicine Rehabilitation 17, no.3 (2007) : 65-89.